WARNING

Consensi is a combination medication that includes amlodipine (a calcium channel blocker) and celecoxib (a nonsteroidal anti-inflammatory drug, NSAID). As with any medication, Consensi carries certain risks that users should be aware of:

• Cardiovascular Risks: Amlodipine can lower blood pressure and may cause side effects such as dizziness or fainting, particularly when standing up quickly. It can also affect heart function in some individuals.
• Gastrointestinal Risks: Celecoxib, being an NSAID, can increase the risk of gastrointestinal ulcers, bleeding, and perforation, especially in elderly patients or those with a history of such conditions.
• Kidney Function: Both amlodipine and NSAIDs like celecoxib can affect kidney function. This risk is higher in individuals with pre-existing kidney disease or those taking other medications that affect the kidneys.
• Allergic Reactions: Some individuals may experience allergic reactions to either amlodipine or celecoxib, ranging from mild rashes to more severe reactions.
• Drug Interactions: Consensi can interact with other medications, including blood thinners, other antihypertensive drugs, and certain antidepressants, potentially causing adverse effects or reducing the effectiveness of one or more medications.
• Liver Function: Celecoxib, like other NSAIDs, can affect liver function tests in some individuals.
• Fluid Retention: Amlodipine may cause fluid retention, which can lead to swelling (edema) in the legs, ankles, or feet.
• Heart Failure: Amlodipine, particularly when used in higher doses, can worsen heart failure symptoms in susceptible individuals.

It’s crucial for individuals taking Consensi to discuss these risks with their healthcare provider and to be monitored regularly for any signs of adverse effects. This medication should only be used as prescribed and under medical supervision to minimize these risks

Why is this medication prescribed?

Consensi is typically prescribed for the treatment of hypertension (high blood pressure) in individuals who also require relief from the symptoms of osteoarthritis, such as pain and inflammation. It combines two active ingredients:

• Amlodipine: A calcium channel blocker that helps to relax blood vessels, thereby lowering blood pressure.
• Celecoxib: A nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, inflammation, and swelling associated with osteoarthritis.

The combination of these two medications in Consensi aims to manage both conditions simultaneously in patients who have both hypertension and osteoarthritis.

How should this medicine be used?

Consensi should be used exactly as prescribed by a healthcare provider. Here are some general guidelines:

• Dosage: The dosage of Consensi will depend on the individual’s medical condition and response to treatment. It is important to follow the prescribed dosage carefully.
• Administration: Consensi tablets are typically taken orally, with or without food. They should be swallowed whole with a glass of water; do not crush, chew, or break the tablets unless instructed otherwise by your doctor or pharmacist.
• Monitoring: Patients taking Consensi should be regularly monitored by their healthcare provider for blood pressure control, kidney function, signs of gastrointestinal issues, and any other potential side effects.
• Avoid Alcohol: It is generally recommended to avoid alcohol while taking Consensi, as alcohol can increase the risk of certain side effects such as dizziness or stomach bleeding.
• Missed Dose: If a dose of Consensi is missed, it should be taken as soon as remembered. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.
• Special Instructions: Patients should inform their healthcare provider about any other medications they are taking, as Consensi can interact with certain drugs.
• Duration of Use: Consensi should be used for the duration prescribed by the healthcare provider, even if symptoms improve. Stopping the medication abruptly can lead to worsening of symptoms.

It’s important for individuals using Consensi to communicate any concerns or unusual symptoms to their healthcare provider promptly to ensure safe and effective treatment.

Other uses for this medicine

Potential off-label uses of Consensi might include:

• Management of Chronic Pain: Celecoxib, one of the components of Consensi, is an NSAID known for its effectiveness in reducing pain and inflammation. It might be prescribed off-label for various chronic pain conditions, such as rheumatoid arthritis or chronic low back pain.
• Combination Therapy: In some cases, healthcare providers might consider using Consensi for individuals with both hypertension and other types of arthritis or inflammatory conditions where NSAID therapy is indicated.

What special precautions should I follow?

Special Precautions for Consensi:

• Hypersensitivity Reactions: Individuals allergic to amlodipine, celecoxib, or other NSAIDs should not use Consensi. Allergic reactions can range from mild rash to severe reactions requiring immediate medical attention.
• Kidney Function: Both amlodipine and NSAIDs like celecoxib can affect kidney function. It is essential to monitor kidney function regularly, especially in patients with pre-existing kidney disease or those taking other medications that affect the kidneys.
• Cardiovascular Risks: Amlodipine can lower blood pressure and affect heart function. This medication should be used cautiously in individuals with heart disease or conditions affecting heart rhythm.
• Gastrointestinal Effects: NSAIDs, including celecoxib, can increase the risk of gastrointestinal ulcers, bleeding, and perforation, particularly in elderly patients. Individuals with a history of gastrointestinal disorders should use Consensi with caution.
• Liver Function: NSAIDs can affect liver function tests. Regular monitoring of liver function is recommended, especially in individuals with pre-existing liver disease or those taking other medications that affect the liver.
• Fluid Retention: Amlodipine may cause fluid retention, which can exacerbate conditions such as congestive heart failure or hypertension.
• Pregnancy and Breastfeeding: Consensi should not be used during pregnancy unless clearly necessary and prescribed by a healthcare provider. It is also not recommended during breastfeeding due to the potential risks to the infant.
• Drug Interactions: Consensi can interact with other medications, including antihypertensives, other NSAIDs, and certain antidepressants. Healthcare providers should be informed of all medications being taken to avoid potential interactions.
• Elderly Patients: Elderly individuals may be more susceptible to the side effects of Consensi, particularly gastrointestinal bleeding and kidney dysfunction.

It’s crucial for individuals prescribed Consensi to adhere strictly to their healthcare provider’s instructions and attend regular follow-up appointments to monitor for any adverse effects or changes in health status.

What special dietary instructions should I follow?

There are no specific dietary restrictions for Consensi. However, to maximize its effectiveness and minimize potential side effects, consider the following general guidelines:

• Alcohol: Limit alcohol consumption while taking Consensi, as it can increase the risk of certain side effects such as dizziness or stomach irritation.
• Food: Consensi can be taken with or without food. If you experience stomach upset, taking it with food may help alleviate symptoms.

What should I do if I forget a dose?

• Take it as soon as you remember: If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not double up: Do not take a double dose to make up for the missed one. Taking more than the prescribed dose can increase the risk of side effects.
• Follow-up with your healthcare provider: If you frequently forget doses, discuss strategies with your healthcare provider to help you remember or adjust your medication schedule if needed.

What side effects can this medication cause?

Consensi, being a combination medication of amlodipine (a calcium channel blocker) and celecoxib (a nonsteroidal anti-inflammatory drug, NSAID), can potentially cause several side effects. It’s important to note that not all individuals will experience these side effects, and their severity can vary. Common side effects of Consensi include:

• Amlodipine-related side effects:
  • Dizziness: Amlodipine can cause dizziness, particularly when standing up quickly.
  • Flushing: Some individuals may experience flushing of the skin.
  • Peripheral edema: Swelling in the ankles, feet, or hands due to fluid retention.
  • Fatigue: Feeling tired or lethargic.
  • Headache: Mild to moderate headaches may occur.
• Celecoxib-related side effects:
  • Gastrointestinal effects: NSAIDs like celecoxib can increase the risk of stomach upset, heartburn, nausea, or diarrhea.
  • Increased blood pressure: Celecoxib may cause a slight increase in blood pressure in some individuals.
  • Dizziness: Similar to amlodipine, celecoxib can also cause dizziness.
  • Rash: Some individuals may develop a rash or skin reactions.
  • Kidney issues: NSAIDs can affect kidney function, leading to fluid retention or worsening of existing kidney problems.
• Serious side effects:
  • Allergic reactions: Rarely, Consensi can cause severe allergic reactions characterized by swelling of the face, throat, or difficulty breathing. Seek immediate medical attention if you experience these symptoms.
  • Cardiovascular effects: Amlodipine can affect heart function in susceptible individuals, potentially leading to chest pain or palpitations.
  • Gastrointestinal bleeding: NSAIDs like celecoxib can increase the risk of gastrointestinal ulcers, bleeding, or perforation, which can be serious and require medical attention.

It’s important to discuss any unusual symptoms or concerns with your healthcare provider promptly. They can provide guidance on managing side effects or adjusting your treatment regimen if necessary. Additionally, do not discontinue Consensi without consulting your healthcare provider, as abrupt cessation can lead to rebound effects or worsening of symptoms. Regular monitoring and communication with your healthcare team are key to managing the potential side effects of Consensi effectively.

What should I know about storage and disposal of this medication?

Storage and Disposal of Consensi:

• Storage: Store Consensi at room temperature, away from light and moisture. Avoid storing it in the bathroom. Keep it out of reach of children and pets.
• Disposal: Dispose of Consensi properly according to local regulations or guidelines. Do not flush medications down the toilet unless instructed to do so. Ask your pharmacist or healthcare provider for information on how to safely dispose of unused or expired medications.

In case of emergency/overdose

• Emergency: If you suspect an overdose of Consensi or experience severe symptoms such as difficulty breathing, severe dizziness, or loss of consciousness, call emergency services (911 in the US) immediately.
• Overdose Symptoms: Symptoms of Consensi overdose may include severe dizziness, fainting, rapid or slow heartbeat, or excessive drowsiness.
• What to Do: If possible, have the medication package or label with you to provide information to healthcare providers. Do not induce vomiting unless instructed by medical personnel.

What other information should I know?

• Regular Monitoring: Follow up with your healthcare provider for regular monitoring of blood pressure, kidney function, and other relevant health parameters.
• Drug Interactions: Inform your healthcare provider about all medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements, to avoid potential interactions with Consensi.
• Pregnancy and Breastfeeding: Consensi is not recommended during pregnancy unless the benefits outweigh the risks. Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Alcohol and Smoking: Limit alcohol intake and avoid smoking while taking Consensi, as these can affect blood pressure and increase the risk of certain side effects.
• Regular Follow-up: Attend scheduled appointments with your healthcare provider to monitor your response to Consensi and to address any concerns or changes in your health.
• Driving and Operating Machinery: Consensi may cause dizziness or drowsiness. Use caution when driving or operating machinery until you know how this medication affects you.

Always consult your healthcare provider or pharmacist if you have any questions or concerns about Consensi or its use. They can provide personalized advice based on your medical history and current medications.