Why is this medication prescribed?

Brolucizumab-dbll Injection, also known by its brand name Beovu, is prescribed to treat a condition called neovascular (wet) age-related macular degeneration (AMD). This condition occurs when abnormal blood vessels grow and leak fluid into the macula, the central part of the retina responsible for sharp, central vision. If left untreated, wet AMD can cause severe vision loss.

Brolucizumab-dbll is a type of medication called an anti-VEGF (vascular endothelial growth factor) inhibitor. It works by blocking the activity of VEGF, a protein that promotes the growth of abnormal blood vessels in the eye. By inhibiting VEGF, brolucizumab helps reduce the growth of these abnormal blood vessels and prevents further damage to the macula, ultimately preserving vision.

How should this medicine be used?

Brolucizumab-dbll Injection is typically administered by a healthcare professional, such as an ophthalmologist, in a clinical setting. Here’s how it is usually used:

• Preparation: The healthcare provider will prepare the Brolucizumab-dbll Injection vial for use. This involves ensuring the vial is intact, checking the expiration date, and inspecting the solution for any discoloration or particles. If the solution appears cloudy or contains particles, it should not be used.
• Administration: The injection is given directly into the eye, specifically into the vitreous cavity, which is the gel-like substance in the center of the eye. Before administering the injection, the eye and surrounding area will be cleaned and numbed with a topical anesthetic to minimize discomfort.
• Injection Technique: The healthcare provider will use a fine needle to carefully deliver the appropriate dose of Brolucizumab-dbll into the vitreous cavity. The injection process typically takes only a few moments.
• Post-Injection Care: After the injection, the healthcare provider may apply pressure to the injection site for a short time to help prevent any leakage of the medication. You may be given eye drops or ointment to use at home to help prevent infection and reduce inflammation.
• Follow-Up: It’s important to attend all follow-up appointments as scheduled by your healthcare provider. These appointments allow your provider to monitor your progress, assess the effectiveness of the treatment, and make any necessary adjustments to your treatment plan.

The dosing schedule for Brolucizumab-dbll Injection may vary depending on your individual condition and response to treatment. Initially, the injection may be given monthly for the first three doses, followed by injections every 8 to 12 weeks thereafter. Your healthcare provider will determine the most appropriate dosing schedule for you.

It’s crucial to follow your healthcare provider’s instructions carefully regarding the administration of Brolucizumab-dbll Injection and any post-injection care recommendations. If you have any questions or concerns about the injection process, be sure to discuss them with your healthcare provider.

Other uses for this medicine

Brolucizumab-dbll Injection is primarily used for the treatment of neovascular (wet) age-related macular degeneration (AMD), as I mentioned earlier. However, it may also be used off-label or for other conditions as determined by your healthcare provider.

What special precautions should I follow?

As for special precautions to take with Brolucizumab-dbll Injection, here are some important points to consider:

• Allergic Reactions: Inform your healthcare provider if you have a history of allergic reactions to any medications or if you have known allergies to any ingredients in Brolucizumab-dbll. Allergic reactions to medications can be serious and may require immediate medical attention.
• Eye Infection: If you have an eye infection or inflammation, your healthcare provider may advise against receiving Brolucizumab-dbll Injection until the infection or inflammation has been treated and resolved.
• Increased Eye Pressure: Brolucizumab-dbll Injection may cause an increase in eye pressure, which can lead to complications such as glaucoma. Your healthcare provider will monitor your eye pressure regularly and may prescribe additional medications to manage it if necessary.
• Retinal Detachment: There have been reports of retinal detachment following Brolucizumab-dbll Injection. Inform your healthcare provider immediately if you experience any symptoms such as sudden onset of floaters, flashes of light, or a curtain-like shadow across your field of vision.
• Pregnancy and Breastfeeding: The safety of Brolucizumab-dbll Injection during pregnancy and breastfeeding is not well established. Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before receiving this medication.
• Driving and Operating Machinery: Brolucizumab-dbll Injection may cause temporary changes in vision, such as blurriness or sensitivity to light, which may affect your ability to drive or operate machinery. Avoid driving or engaging in activities that require clear vision until your vision has returned to normal.
• Other Medications: Inform your healthcare provider about all medications, vitamins, and supplements you are currently taking, as they may interact with Brolucizumab-dbll Injection.

It’s essential to follow your healthcare provider’s instructions closely and communicate any concerns or changes in your condition during treatment with Brolucizumab-dbll Injection. Regular follow-up appointments are crucial for monitoring your progress and addressing any potential side effects or complications.

What special dietary instructions should I follow?

Regarding special dietary instructions for Brolucizumab-dbll Injection, there are typically no specific dietary restrictions associated with this medication. However, maintaining a healthy and balanced diet can support overall eye health and may complement the treatment regimen prescribed by your healthcare provider.

What should I do if I forget a dose?

If you forget a dose of Brolucizumab-dbll Injection, contact your healthcare provider as soon as possible to reschedule the missed appointment. It’s essential to adhere to the recommended dosing schedule to ensure the effectiveness of the treatment. Missing a dose may affect the stability of the condition being treated and may require adjustments to the treatment plan. Avoid self-administering doses or trying to “catch up” by taking extra doses without consulting your healthcare provider.

What side effects can this medication cause?

Brolucizumab-dbll Injection, like any medication, can cause side effects, although not everyone will experience them. Common side effects of Brolucizumab-dbll Injection may include:

• Eye Irritation: This can manifest as redness, itching, or discomfort in the treated eye.
• Increased Intraocular Pressure: Brolucizumab-dbll can sometimes lead to an increase in pressure inside the eye, which may cause symptoms such as eye pain, blurred vision, or seeing halos around lights.
• Floaters: Some people may experience an increase in floaters, which are small specks or clouds moving in your field of vision.
• Conjunctival Hemorrhage: This is bleeding under the clear, thin tissue covering the white part of the eye, which can cause a red spot on the eye.
• Eye Inflammation: Inflammation of the eye, known as uveitis, may occur, leading to symptoms such as redness, pain, and sensitivity to light.
• Eye Infection: While rare, there is a risk of developing an eye infection following the injection.
• Retinal Detachment: In some cases, Brolucizumab-dbll Injection may increase the risk of retinal detachment, which can cause symptoms such as sudden flashes of light, floaters, or a curtain-like shadow across your field of vision.
• Allergic Reactions: Although uncommon, allergic reactions to Brolucizumab-dbll Injection can occur. Symptoms may include rash, itching, swelling, dizziness, or difficulty breathing.

It’s important to report any side effects or changes in your vision to your healthcare provider promptly. They can provide guidance on managing side effects and determine whether any adjustments to your treatment plan are necessary. Additionally, if you experience any severe or concerning symptoms after receiving the injection, seek medical attention immediately.

What should I know about storage and disposal of this medication?

Here’s what you should know about the storage and disposal of Brolucizumab-dbll Injection:

Storage:

• Brolucizumab-dbll Injection should be stored in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).
• Do not freeze Brolucizumab-dbll Injection.
• Keep the medication in its original carton to protect it from light.
• Do not shake the vial. Gently swirl the vial to mix the solution before use.
• If needed, Brolucizumab-dbll Injection can be kept at room temperature (up to 25°C or 77°F) for a single period of up to 24 hours. Discard any unused portion after 24 hours if not used.

Disposal:

• Dispose of used needles and syringes in a puncture-resistant container as per local regulations or guidelines provided by your healthcare provider.
• Do not reuse needles or syringes.
• Dispose of any unused or expired Brolucizumab-dbll Injection according to local regulations. Your healthcare provider or pharmacist can provide guidance on safe disposal methods.

In case of emergency/overdose

• If you suspect an overdose or experience severe adverse reactions after receiving Brolucizumab-dbll Injection, seek immediate medical attention or contact your local poison control center.
• Be prepared to provide information about the dose you received, the time of administration, and any symptoms you are experiencing.

What other information should I know?

• Keep all appointments with your healthcare provider for injections and follow-up assessments.
• Inform your healthcare provider about all medications, vitamins, and supplements you are taking, as they may interact with Brolucizumab-dbll Injection.
• Report any changes in your vision or eye health to your healthcare provider promptly.
• Follow your healthcare provider’s instructions carefully regarding the dosing schedule and any special precautions or dietary instructions.
• Keep Brolucizumab-dbll Injection out of reach of children and pets.
• Do not share needles or syringes with others.

By following these guidelines, you can ensure the safe and effective use of Brolucizumab-dbll Injection while minimizing the risk of adverse events.