WARNING

Anjeso (generic name: Meloxicam Injection) is a nonsteroidal anti-inflammatory drug (NSAID) used primarily to treat pain and inflammation. While effective, it does come with a range of potential risks and side effects. Here are the detailed risks associated with taking Anjeso:

• Ulcers and Bleeding: NSAIDs, including Meloxicam, can increase the risk of developing gastrointestinal ulcers and bleeding. This risk is higher in people with a history of ulcers or gastrointestinal bleeding.
• Gastrointestinal Perforation: In rare cases, NSAIDs can cause a hole to form in the wall of the stomach or intestines, leading to serious infections or other complications.
• Heart Attack and Stroke: Prolonged use of NSAIDs may increase the risk of heart attack or stroke, particularly in people with existing cardiovascular conditions.
• High Blood Pressure: Meloxicam may cause or worsen high blood pressure, potentially leading to further cardiovascular issues.
• Kidney Damage: Long-term use or high doses of Meloxicam can lead to kidney damage or failure. Symptoms may include decreased urine output or swelling in the legs and ankles.
• Fluid Retention: NSAIDs can cause fluid retention, which may exacerbate kidney problems and lead to edema.
• Liver Damage: Although rare, Meloxicam can cause liver damage, which might manifest as jaundice (yellowing of the skin or eyes) or elevated liver enzymes.
• Hypersensitivity Reactions: Some people may experience allergic reactions, including rash, itching, or severe reactions like anaphylaxis.
• Exacerbation of Asthma: NSAIDs can sometimes worsen asthma symptoms or trigger asthma attacks in susceptible individuals.
• Severe Skin Reactions: Rarely, Meloxicam can cause severe skin reactions such as Stevens-Johnson Syndrome or toxic epidermal necrolysis, which require immediate medical attention.
• Interactions with Other Medications: Meloxicam can interact with other medications, including blood thinners, other NSAIDs, and certain antidepressants, potentially leading to adverse effects or reduced effectiveness of the drugs.
• Pregnancy: Meloxicam is generally not recommended during pregnancy, especially in the third trimester, as it may harm the unborn baby or cause complications during delivery.
• Breastfeeding: It is advised to consult with a healthcare provider before using Meloxicam while breastfeeding.
• Regular Monitoring: Regular monitoring of kidney function, liver function, and blood pressure is recommended for those on long-term Meloxicam therapy.
• Avoiding High Doses: Use the lowest effective dose for the shortest duration necessary to minimize risks.
• Medical History: Inform your healthcare provider of your complete medical history, including any history of cardiovascular, gastrointestinal, or kidney issues, before starting Meloxicam.

Always consult with your healthcare provider for personalized advice and to discuss the benefits and risks specific to your health condition.

Why is this medication prescribed?

Anjeso (Generic Meloxicam Injection) is prescribed to relieve moderate to severe pain, usually following surgery. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing the production of certain substances in the body that cause inflammation, pain, and fever.

How should this medicine be used?

Here’s a general guide on how it is typically used:

• Administration: Anjeso is given as a single intravenous (IV) injection over 15 seconds by a healthcare professional in a hospital or clinical setting. It is typically administered once daily.
• Dosage: The usual dosage is 30 mg once daily, but the specific dose and duration of treatment depend on the patient’s condition and response to the medication. It is typically not used for more than 24 hours.
• Precautions: Anjeso should be used at the lowest effective dose for the shortest duration necessary to manage pain. It is important to monitor for signs of gastrointestinal bleeding, cardiovascular events, or kidney and liver issues, especially in patients with a history of these conditions.

Inform your healthcare provider of any medications or supplements you are taking to avoid potential drug interactions.

Other uses for this medicine

While Anjeso is primarily prescribed for the relief of moderate to severe pain following surgery, it may sometimes be used off-label for other types of acute pain management. However, the use of Anjeso for other conditions is determined by a healthcare provider based on individual patient needs and clinical judgment.

What special precautions should I follow?

Special Precautions to Follow for Anjeso:

• Allergies: Inform your doctor if you are allergic to meloxicam, aspirin, other NSAIDs, or any of the ingredients in Anjeso. If you have experienced allergic reactions like rash, itching, swelling, dizziness, or trouble breathing when using NSAIDs, you should avoid using Anjeso.
• Medical History: Discuss your medical history, especially if you have a history of cardiovascular disease (e.g., heart attack, stroke, hypertension), gastrointestinal issues (e.g., ulcers, bleeding), kidney or liver disease, asthma, or any bleeding disorders. Inform your doctor if you have ever had an allergic reaction to sulfa drugs, as this could increase the risk of an adverse reaction to meloxicam.
• Pregnancy and Breastfeeding: Anjeso should generally be avoided during pregnancy, especially after 20 weeks of gestation, due to the risk of harm to the fetus. It may cause premature closure of the ductus arteriosus, a vital blood vessel in the fetus. Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Drug Interactions: Anjeso may interact with other medications, including blood thinners (e.g., warfarin), other NSAIDs, aspirin, diuretics, ACE inhibitors, angiotensin II receptor blockers (ARBs), and certain antidepressants (SSRIs or SNRIs). Ensure your healthcare provider is aware of all medications and supplements you are taking.
• Alcohol and Smoking: Limit alcohol consumption while taking Anjeso, as it can increase the risk of stomach bleeding. Smoking can increase the risk of stomach bleeding when using NSAIDs.
• Monitoring: Regular monitoring of blood pressure, kidney function, and liver function is advised, especially in patients with a history of hypertension, kidney disease, or liver disease. Be aware of signs of gastrointestinal bleeding, such as black or tarry stools, or severe abdominal pain, and seek immediate medical attention if they occur.
• Avoid Certain Activities: Anjeso can cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.

Always follow the specific guidance provided by your healthcare provider and consult them with any concerns or questions about Anjeso. Regular monitoring and communication with your provider are essential for safe and effective use.

What special dietary instructions should I follow?

• General Diet: No specific dietary restrictions are required while using Anjeso. However, taking it with food may help prevent stomach upset.
• Avoid Alcohol: Limiting alcohol consumption is advised to reduce the risk of stomach bleeding.
• Hydration: Stay well-hydrated, especially if you have kidney concerns or are at risk for dehydration.

What should I do if I forget a dose?

Anjeso is typically administered by a healthcare professional as a single dose in a clinical setting, so missing a dose is unlikely. However, if you believe you missed a scheduled dose, contact your healthcare provider for guidance. Do not attempt to double the dose to make up for a missed one.

What side effects can this medication cause?

Anjeso, like any medication, may cause side effects. It’s important to be aware of them and consult your healthcare provider if you experience any. These side effects are usually mild and may resolve on their own. However, if they persist or worsen, consult your healthcare provider.

Common Side Effects:

• Nausea
• Vomiting
• Constipation
• Headache
• Dizziness
• Fever
• Swelling at the injection site

Serious Side Effects:

• Gastrointestinal Issues: Stomach or intestinal bleeding, which can be life-threatening. Symptoms may include severe stomach pain, black or tarry stools, or vomiting blood.
• Cardiovascular Effects: Increased risk of heart attack, stroke, or other cardiovascular events. Seek immediate medical attention if you experience chest pain, shortness of breath, weakness on one side of the body, or slurred speech.
• Kidney Problems: Reduced kidney function, especially in those with pre-existing kidney disease or those who are dehydrated. Signs may include changes in the amount of urine, swelling in the legs or feet, and unusual tiredness.
• Liver Damage: Symptoms can include yellowing of the skin or eyes (jaundice), dark urine, severe nausea or vomiting, and unusual fatigue.
• Severe Allergic Reactions: Such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing.
• Skin Reactions: Serious skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis. Symptoms may include rash, blistering, or peeling of the skin.
• Hypertension: An increase in blood pressure may occur. Regular monitoring is recommended, especially in patients with existing hypertension.
• Blood Disorders: Anemia or other blood disorders, which may manifest as fatigue, easy bruising or bleeding, or pale skin.

If you experience any unusual symptoms or side effects not listed here, contact your healthcare provider immediately.

Contact your healthcare provider if you experience mild side effects that persist or become bothersome. Seek immediate medical attention if you experience any symptoms of severe infection, allergic reaction, or other serious side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Anjeso:

• Storage:
  • Store Anjeso at room temperature, typically between 20°C to 25°C (68°F to 77°F). Protect it from light and moisture.
  • Ensure that the medication is stored in its original container, and keep it out of reach of children and pets.
  • Do not use Anjeso after the expiration date printed on the label. If the medication has expired or is no longer needed, it should be disposed of properly.
• Disposal:
  • Do not dispose of Anjeso by flushing it down the toilet or pouring it into a drain.
  • Check with your pharmacist or local waste disposal facility about medication take-back programs or proper disposal methods.
  • If no take-back program is available, you may dispose of the medication in your household trash by mixing it with an undesirable substance (like used coffee grounds or kitty litter) and placing it in a sealed plastic bag before throwing it away. However, this is a less preferred method.

In case of emergency/overdose

• Symptoms of Overdose: Symptoms of an overdose may include severe drowsiness, confusion, nausea, vomiting, stomach pain, or even more severe effects such as gastrointestinal bleeding or kidney failure.
• Seek Immediate Help: If an overdose is suspected, contact emergency medical services (911) or go to the nearest emergency room right away.
• Contact Poison Control: You can also contact a poison control center for immediate advice on what to do in the event of an overdose.

What other information should I know?

• Follow-Up: Regular follow-up with your healthcare provider is essential to monitor for any adverse effects or complications related to the use of Anjeso.
• Interactions: Keep your healthcare provider informed about all other medications and supplements you are taking to avoid potential interactions.
• Adherence: Ensure that you follow the prescribed dosage and administration guidelines to avoid complications and achieve the desired pain relief.
• Pregnancy and Breastfeeding: Discuss any concerns with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Always follow the specific instructions given by your healthcare provider and consult them with any questions or concerns regarding Anjeso.