Why is this medication prescribed?

Apomorphine sublingual is prescribed primarily for the treatment of Parkinson’s disease and Parkinsonian symptoms. It is used as a “rescue” medication to quickly alleviate motor symptoms such as tremors, rigidity, and bradykinesia (slowness of movement) that can occur during “off” periods when other Parkinson’s medications are not effective. Here’s a brief overview of its uses:

• Parkinson’s Disease: Helps manage motor symptoms during periods when the effects of other Parkinson’s medications are wearing off.
• Motor Fluctuations: Provides relief from sudden or unexpected worsening of Parkinson’s symptoms, often referred to as “off” episodes.

Apomorphine works by stimulating dopamine receptors in the brain, which helps improve motor function. It’s typically used when other treatments are not sufficient or when rapid relief of symptoms is needed.

How should this medicine be used?

Apomorphine sublingual is used by placing the tablet under your tongue. Here’s a step-by-step guide on how to use it:

• Preparation: Ensure your hands are clean before handling the tablet.
• Administration: Place the tablet under your tongue. Do not chew or swallow the tablet.
• Dissolution: Allow the tablet to dissolve completely in your mouth. This can take a few minutes. Avoid drinking or eating anything until the tablet is fully dissolved.
• Dosage: Follow your healthcare provider’s instructions regarding the dosage and frequency. The dose is usually determined based on your individual needs and response to the medication.
• Storage: Store the tablets in their original container at room temperature, away from moisture and heat.
• Monitoring: Monitor for any side effects or reactions, and report them to your healthcare provider.

Always follow your healthcare provider’s specific instructions for your dosage and usage, as individual needs can vary.

Other uses for this medicine

Apomorphine sublingual is primarily used for managing motor symptoms associated with Parkinson’s disease. It is not typically used for conditions other than Parkinson’s disease-related motor fluctuations. Its main role is to provide rapid relief during “off” episodes when other Parkinson’s medications are not effective.

What special precautions should I follow?

Special Precautions for Apomorphine Sublingual:

• Allergies: Inform your healthcare provider if you have any allergies, especially to apomorphine or any other medications.
• Medical History: Share your complete medical history with your healthcare provider, particularly if you have a history of heart disease, low blood pressure, or mental health conditions.
• Medication Interactions: Be cautious with other medications, especially those that affect blood pressure or interact with dopamine. Inform your provider about all medications and supplements you’re taking.
• Blood Pressure Monitoring: Apomorphine can cause a drop in blood pressure. Monitor your blood pressure regularly and report any significant changes to your healthcare provider.
• Drowsiness and Coordination: Apomorphine may cause drowsiness or affect coordination. Avoid activities that require full alertness, such as driving, until you know how the medication affects you.
• Side Effects: Watch for side effects such as nausea, dizziness, hallucinations, or sudden mood changes. Report these to your healthcare provider.
• Pregnancy and Breastfeeding: If you are pregnant, plan to become pregnant, or are breastfeeding, discuss the risks and benefits with your healthcare provider.
• Mental Health: Apomorphine can affect mood and mental status. If you experience any significant changes in mood, anxiety, or other psychological symptoms, seek medical advice.

Always follow your healthcare provider’s guidance and read the patient information leaflet provided with your medication for more detailed information.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions with apomorphine sublingual. However, it’s important to maintain a balanced diet and stay hydrated. If you have concerns or if your healthcare provider gives specific dietary advice related to your overall treatment plan, follow their recommendations.

What should I do if I forget a dose?

• Timing: If you remember within a reasonable time frame, take the missed dose as soon as possible.
• Next Dose: If it is almost time for your next scheduled dose, skip the missed dose. Do not double up on doses to make up for a missed dose.
• Contact Provider: If you have missed a dose or have any questions about what to do, contact your healthcare provider for further instructions.

What side effects can this medication cause?

Apomorphine sublingual can cause a range of side effects, some of which may be more common or severe. Here are potential side effects:

Common Side Effects:

• Nausea and Vomiting: These are relatively common and may improve over time.
• Dizziness or Lightheadedness: Often due to its effect on blood pressure.
• Drowsiness: May affect your alertness and coordination.
• Headache: Can occur as part of the medication’s effects.

Serious Side Effects:

• Severe Allergic Reactions: Symptoms may include rash, itching, swelling, severe dizziness, or trouble breathing.
• Hallucinations or Delusions: Mental status changes, including confusion or hallucinations, can occur.
• Sudden Mood Changes: Significant changes in mood or behavior may happen.
• Fainting or Severe Dizziness: Often related to a significant drop in blood pressure.
• Chest Pain: Any chest pain should be evaluated immediately.
• Severe Skin Reactions: Includes severe rash or blisters.
• Uncontrolled Movements: Such as muscle twitching or jerking.

If you experience any of these serious side effects or if you have symptoms that are severe or persistent, contact your healthcare provider immediately. For less severe side effects that are bothersome or persistent, discuss them with your provider to determine if adjustments to your treatment are necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Apomorphine Sublingual:

Storage:

• Store the tablets at room temperature, away from heat and moisture.
• Keep them in their original container with the lid tightly closed to protect them from light and moisture.
• Store out of reach of children and pets.

Disposal:

• Do not flush the medication down the toilet or pour it into a drain unless instructed to do so.
• If you have unused or expired medication, use a drug take-back program if available.
• Follow any specific disposal instructions provided with the medication or by your pharmacist.

In case of emergency/overdose

Symptoms of Overdose:

• Severe dizziness or fainting
• Uncontrolled movements or muscle twitching
• Severe drowsiness or confusion
• Nausea or vomiting

Actions to Take:

• Seek Immediate Medical Help: If you suspect an overdose or experience severe symptoms, seek emergency medical help immediately.
• Contact Poison Control: If you are unsure about the severity or what to do, contact your local poison control center.

What other information should I know?

• Follow Instructions: Always adhere to your healthcare provider’s dosing instructions and schedule.
• Regular Check-ups: Have regular follow-up appointments with your healthcare provider to monitor your condition and adjust treatment if necessary.
• Medication List: Keep a current list of all your medications and share it with any healthcare providers you visit.
• Side Effects: Report any new or unusual symptoms to your healthcare provider as soon as possible.

By following these guidelines and staying in communication with your healthcare provider, you can manage your treatment safely and effectively.