A tablet to be swallowed with food contains axitinib. It is often taken twice daily, with or without food. Axitinib should be taken every day at around the same times, separated by 12 hours. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Administer axitinib precisely as prescribed. Never take it in larger or smaller amounts or more frequently than directed by your doctor.

With a glass of water, swallow the pills whole; do not break, chew, or crush them.

Do not take another dose of axitinib if you vomit after taking it. Continue taking your medication as usual.

Axitinib dosages can be progressively increased by your doctor, not more frequently than once every two weeks. This is dependent upon how effectively the medication functions for you and any potential adverse effects. Discuss your feelings regarding your treatment with your doctor. Axitinib should be taken even if you feel fine. Axitinib should not be stopped without consulting your doctor.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before taking axitinib,

• If you have an allergy to axitinib, any other medications, or any of the ingredients in axitinib tablets, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, and dietary supplements you are currently taking or intend to take. Mention any of the following: atazanavir (Reyataz), efavirenz (Sustiva, in Atripla), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase); modafinil (Provigil); nafcillin; nefazo (Vfend). Tell your doctor about all of the drugs you are taking, even any not on this list, as many other drugs may also interact with axitinib.
• Please let your doctor know if you are taking any herbal supplements, especially St. John’s wort.
• A wound that has not healed, bleeding issues, blood clots, high blood pressure, a heart attack, diabetes, high cholesterol, stomach or intestinal bleeding, brain cancer, pulmonary embolism (blood clot in your lung), a stroke or ministroke (TIA), or heart, liver, or thyroid disease are all things you should mention to your doctor.
• Inform your physician if you are expecting, intend to become pregnant, or intend to father a child. You must perform a pregnancy test before beginning therapy if you are a female, and you must use birth control to avoid getting pregnant while receiving treatment and for one week following the last dose. If you’re a man, you should utilise birth control while receiving therapy and for one week following your last dose, together with your female partner. Discuss effective birth control options with your doctor. Call your doctor if you or your partner becomes pregnant while taking axitinib. The foetus could suffer from axitinib.
• Inform your doctor if you are nursing a child. Axitinib medication should be discontinued during pregnancy and for two weeks following the last dosage.
• You should be aware that this medicine may lower both male and female fertility. The dangers of taking axitinib should be discussed with your doctor.
• Inform your doctor or dentist that you are taking axitinib if you are having surgery, including dental surgery. Your doctor will let you know when it is okay for you to resume taking axitinib after surgery and when you should stop taking it at least two days before to the procedure.

While using this medication, avoid grapefruit and grapefruit juice.

Keep eating normally unless your doctor instructs you otherwise.

Axitinib missed doses should be skipped in favour of the next dose, which should be taken at the scheduled time. To make up for a missing dose, do not take a second one.

Axitinib could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Diarrhea
• A reduction in appetite or taste sensations
• Loss of weight
• Nausea
• Vomiting
• Constipation
• Tiredness
• Weakness
• Your voice will sound different now.
• Redness, discomfort, tingling, numbness, itching, or peeling of the hands’ and feet’s skin are all possible symptoms.
• Cough
• Muscle or joint pain
• Oral sores
• Abdominal pain
• Chest pain
• Headache
• Dizziness
• Rash
• Itching
• Arid skin
• Is it hot or cold?
• Light skin
• Rapid heart rate
• Hair fall
• An earache that ringers
• Thirst
• Hemorrhoids
• A cut or wound that won’t mend

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical help:

• A terrible tummy ache
• Breathing difficulty
• Feet or hands swelling
• Uncommon bruising or bleeding
• Seats that are dark and tarry
• Blood in the faeces, red
• Bloody poop
• Vomiting something that resembles coffee grinds
• Chest pressure or discomfort
• Arms, back, neck, or jaw pain
• Leg enlargement, tenderness, warmth, or rosiness
• Face, arm, or leg weakness that appears out of nowhere (especially on one side of the body)
• Sudden difficulty comprehending, speaking, or speaking clearly
• Sudden trouble seeing in one or both eyes
• Sudden difficulty walking, lightheadedness, imbalance, or lack of coordination
• Strong headache that appears out of the blue
• Seizure
• Absence of vision

Other negative effects of axitinib are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

• Dizziness
• Seizures
• Exhaling blood

Keep all of your appointments with your physician and the lab. To monitor your body’s response to axitinib, your doctor will request specific lab tests. Throughout your axitinib treatment, your doctor will also routinely monitor your blood pressure.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.