WARNING

Taking Axiron (generic testosterone topical) involves several potential risks and side effects. Here’s a detailed overview of these risks:

• Heart Attack and Stroke: Testosterone therapy has been associated with an increased risk of heart attack and stroke, especially in older men or those with pre-existing heart conditions.
• Blood Clots: There may be an increased risk of developing blood clots, which can lead to deep vein thrombosis (DVT) or pulmonary embolism.
• Prostate Enlargement: Testosterone can stimulate the growth of the prostate, potentially leading to benign prostatic hyperplasia (BPH), which can cause urinary problems.
• Prostate Cancer: There is a potential risk of worsening pre-existing prostate cancer or increasing the risk of developing it.
• Liver Damage: While less common with topical formulations, testosterone can affect liver function. Symptoms of liver issues include jaundice (yellowing of the skin or eyes), dark urine, and abdominal pain.
• Mood Swings: Some users may experience mood swings, irritability, or increased aggression.
• Mental Health: There is a risk of developing or worsening psychiatric symptoms such as severe anxiety or depression.
• Local Reactions: Common side effects include skin irritation, redness, and itching at the application site.
• Transfer Risk: There is a risk of transferring testosterone to others through skin contact, which can cause unintended side effects, especially in women and children.
• Sleep Apnea: Testosterone therapy may exacerbate or trigger sleep apnea, a condition where breathing repeatedly stops and starts during sleep.
• Edema: Fluid retention can occur, leading to swelling in the legs or ankles and potentially contributing to high blood pressure.
• Infertility: Long-term use of testosterone can lead to decreased sperm production and fertility issues.
• Gynecomastia: Development of breast tissue in men (gynecomastia) can occur.
• Diabetes: Testosterone therapy may affect blood sugar levels, which can be a concern for people with diabetes or those at risk of developing diabetes.

If you experience any concerning symptoms or have questions about the risks associated with Axiron, consult your healthcare provider for personalized advice and management strategies.

Why is this medication prescribed?

Axiron (generic testosterone topical) is prescribed to treat low testosterone levels in men, a condition known as male hypogonadism. Symptoms of low testosterone can include fatigue, reduced libido, erectile dysfunction, depression, and decreased muscle mass. Axiron helps to restore normal testosterone levels, which can improve these symptoms and overall quality of life.

In some cases, it may also be used to address issues related to hormone imbalances and to support various aspects of physical and emotional health that are influenced by testosterone.

How should this medicine be used?

Axiron (generic testosterone topical) should be used according to the following steps:

• Application Site: Apply Axiron to clean, dry skin on the underarms (armpits). This area is preferred because testosterone can be absorbed effectively through the skin here.
• Dosage: Follow your healthcare provider’s instructions on the exact dosage and frequency. Typically, it’s applied once daily.
• Application: Use the applicator provided with the medication. Apply a thin layer of the gel to the area and rub it in gently until it’s fully absorbed. Avoid applying the gel to broken or irritated skin.
• Washing Hands: After applying the gel, wash your hands thoroughly with soap and water to avoid transferring the medication to others.
• Avoid Contact: Allow the application site to dry completely before dressing to avoid transferring the medication to clothing or other surfaces. Additionally, avoid skin-to-skin contact with others, especially women and children, until the gel is dry.
• Clothing: Wear clothing that covers the application area if you’re in contact with others to reduce the risk of accidental transfer.
• Storage: Store Axiron at room temperature, away from heat and moisture, and keep it out of reach of children.

Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about how to use Axiron.

Other uses for this medicine

• Hypogonadism: Axiron is primarily used to treat male hypogonadism, but it may also be prescribed to address testosterone deficiencies due to conditions like pituitary disorders or testicular damage.
• Hormone Replacement Therapy: It can be part of a broader hormone replacement therapy plan to help manage symptoms related to low testosterone levels.
• Bone Health: In some cases, testosterone therapy is used to help prevent bone loss in men with low testosterone, as it can impact bone density.

What special precautions should I follow?

Special Precautions for Axiron (Generic Testosterone Topical):

• Skin Contact: Avoid direct skin-to-skin contact with others, especially women and children, in the area where Axiron is applied. The gel can be transferred and potentially cause unintended effects.
• Pregnancy: Pregnant women should avoid contact with areas where Axiron has been applied due to the risk of adverse effects on a developing fetus.
• Pre-existing Conditions: Inform your healthcare provider if you have pre-existing conditions such as heart disease, liver disease, or prostate problems. Testosterone therapy can exacerbate certain health issues.
• Monitoring: Regular follow-ups with your healthcare provider are important to monitor testosterone levels and check for any potential side effects or complications.
• Side Effects: Be aware of potential side effects like skin irritation, increased risk of blood clots, or changes in mood. Report any unusual symptoms to your healthcare provider.
• Drug Interactions: Inform your healthcare provider about all other medications and supplements you are taking, as there may be interactions with Axiron.
• Storage: Store the medication as directed, typically at room temperature, and keep it away from children and pets.

Always follow the specific instructions provided by your healthcare provider and the medication’s labeling.

What special dietary instructions should I follow?

There are no specific dietary restrictions or special instructions directly related to Axiron. However, maintaining a balanced diet can support overall health and well-being. If you have any dietary concerns or conditions that might affect testosterone levels or your overall health, discuss them with your healthcare provider.

What should I do if I forget a dose?

• Timing: If you forget to apply your dose of Axiron, apply it as soon as you remember.
• Missed Dose: If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra gel to make up for the missed dose.
• Consult Provider: If you frequently miss doses or are unsure about what to do, consult your healthcare provider for specific instructions.

What side effects can this medication cause?

Axiron (generic testosterone topical) can cause a range of side effects, though not everyone will experience them. Common and serious side effects include:

Common Side Effects:

• Skin Reactions: Application site reactions such as redness, irritation, or itching.
• Headaches: Mild to moderate headaches.
• Acne: Development or worsening of acne.
• Changes in Libido: Alterations in sexual desire or function.
• Mood Changes: Variations in mood, such as increased aggression or irritability.

Serious Side Effects:

• Cardiovascular Issues: Increased risk of heart attack, stroke, or blood clots.
• Prostate Problems: Potential for enlarged prostate or worsening of prostate cancer symptoms.
• Liver Issues: Signs of liver problems like jaundice (yellowing of the skin or eyes), dark urine, or severe abdominal pain.
• Behavioral Changes: Significant mood swings or psychiatric symptoms, such as severe anxiety or depression.
• Breast Changes: Development of breast tissue or tenderness (gynecomastia).
• Sleep Apnea: Worsening or development of sleep apnea.
• Fluid Retention: Swelling in the legs or ankles, or sudden weight gain.

If you experience any severe or concerning symptoms, seek medical attention immediately. Regular follow-ups with your healthcare provider can help monitor for side effects and adjust treatment as needed.

What should I know about storage and disposal of this medication?

Storage and Disposal of Axiron (Generic Testosterone Topical):

Storage:

• Store Axiron at room temperature, typically between 68°F to 77°F (20°C to 25°C).
• Keep it away from heat, moisture, and direct sunlight.
• Store the medication in a secure place, out of reach of children and pets.

Disposal:

• Do not dispose of Axiron in household trash or down the drain.
• Use drug take-back programs or follow local disposal guidelines to properly discard unused or expired medication.
• If you’re unsure about disposal methods, consult your pharmacist for advice.

In case of emergency/overdose

• Symptoms: Overdose symptoms may include nausea, vomiting, or more severe reactions related to high testosterone levels.
• Immediate Action: Contact your healthcare provider or local poison control center immediately if you suspect an overdose.
• Emergency Room: Go to the nearest emergency room if you experience severe symptoms or if advised by a healthcare professional.
• Poison Control Center: Keep the contact information for your local poison control center handy.
• Healthcare Provider: Have your healthcare provider’s contact information available for urgent advice.

What other information should I know?

• Adherence: Follow the prescribed dosage and application instructions carefully for optimal effectiveness.
• Interactions: Be aware of potential interactions with other medications and supplements. Inform your healthcare provider of all substances you are taking.
• Regular Monitoring: Regular check-ups with your healthcare provider are essential to monitor testosterone levels and overall health.
• Symptoms to Report: Report any new or worsening symptoms, including those that might indicate side effects or complications, to your healthcare provider promptly.
• Health Changes: Notify your healthcare provider of any significant changes in your health status or underlying conditions that could impact your treatment.

If you have any additional questions or concerns about Axiron, don’t hesitate to reach out to your healthcare provider for personalized guidance.