Why is this medication prescribed?

Aredia (pamidronate) is prescribed for several conditions related to bone health. Its primary uses include:

• Paget’s Disease of Bone: A condition where the bones become enlarged and deformed.
• Hypercalcemia of Malignancy: High calcium levels in the blood due to cancer.
• Bone Metastases: To help manage bone damage caused by certain types of cancer that have spread to the bones, such as breast cancer or prostate cancer.
• Osteoporosis: To help increase bone density and reduce the risk of fractures (although other bisphosphonates are more commonly used for this purpose).

Pamidronate works by slowing down the activity of cells that break down bone, thereby helping to maintain bone strength and density.

How should this medicine be used?

Aredia (pamidronate) is typically administered as an intravenous (IV) infusion. Here’s a general guide on how it’s used:

• Administration: Pamidronate is given by a healthcare provider through an intravenous (IV) infusion. It is usually administered in a medical setting such as a hospital or clinic.
• Dosage: The dosage and frequency of the infusion depend on the condition being treated and the patient’s response. For Paget’s disease, it may be administered as a single infusion every 6 months. For hypercalcemia of malignancy, it might be given more frequently, depending on the severity of the condition.
• Preparation: The medication is mixed with a suitable intravenous fluid before administration. The infusion is usually given over a period of several hours.
• Monitoring: During and after the infusion, the patient’s vital signs and kidney function may be monitored to ensure there are no adverse reactions or complications.
• Hydration: Patients are often encouraged to stay well-hydrated before and after the infusion to help prevent potential kidney problems.
• Follow-Up: Regular follow-up appointments may be required to assess the effectiveness of the treatment and to monitor for any side effects.

Always follow your healthcare provider’s specific instructions regarding the use of Aredia.

Other uses for this medicine

Besides the primary uses mentioned earlier, Aredia (pamidronate) can be used for:

• Bone Pain Relief: In some cases, it may be used to help alleviate bone pain associated with conditions like metastatic bone disease.
• Osteogenesis Imperfecta: Though less common, it may be used in some cases to manage this genetic bone disorder.

What special precautions should I follow?

When using Aredia, it’s important to follow these precautions:

• Kidney Function: Ensure kidney function is monitored regularly, as pamidronate can affect kidney function. Adequate hydration is crucial to minimize this risk.
• Dental Health: Inform your dentist and healthcare provider if you are receiving Aredia, as bisphosphonates can increase the risk of osteonecrosis of the jaw, especially if you have dental procedures or poor oral hygiene.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of pamidronate in these situations has not been well-studied.
• Drug Interactions: Be aware of potential interactions with other medications. Inform your healthcare provider about all the medicines you are taking.
• Hypocalcemia: Monitor for symptoms of low calcium levels (hypocalcemia), such as muscle cramps or twitching, as pamidronate can affect calcium metabolism.
• Bone Pain or Other Symptoms: Report any unusual bone pain or symptoms to your healthcare provider, as they could indicate complications related to the treatment.

Always follow the specific guidance of your healthcare provider regarding the use of Aredia to ensure safety and effectiveness.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Aredia. However, maintaining a balanced diet and staying hydrated is beneficial. If you experience any issues with your calcium or vitamin D levels, your healthcare provider may provide tailored advice.

What should I do if I forget a dose?

• Contact Your Healthcare Provider: Inform them as soon as possible. They will provide guidance on how to proceed, which may include rescheduling your infusion.
• Do Not Double Up: Do not attempt to make up for a missed dose by doubling up on your next infusion. Follow your healthcare provider’s instructions for catching up on missed doses.

What side effects can this medication cause?

Aredia (pamidronate) can cause a range of side effects. Some of the common and serious side effects include:

Common Side Effects:

• Flu-like Symptoms: Fever, chills, muscle aches, or fatigue.
• Gastrointestinal Issues: Nausea, vomiting, or abdominal pain.
• Bone, Joint, or Muscle Pain: This can be a common reaction after the infusion.
• Headache: Some people may experience headaches.

Serious Side Effects:

• Osteonecrosis of the Jaw: A rare but serious condition where the jawbone starts to die, often associated with dental procedures.
• Kidney Problems: Symptoms may include decreased urine output, swelling, or shortness of breath.
• Hypocalcemia: Low calcium levels in the blood, which can cause muscle cramps, twitching, or numbness.
• Severe Allergic Reactions: Symptoms may include rash, itching, swelling, severe dizziness, or trouble breathing.
• Eye Irritation: Rarely, Aredia can cause eye issues such as conjunctivitis or uveitis.
• Unusual Bone Pain: Severe or persistent bone pain that may indicate a condition called atypical femoral fracture.

If you experience any severe or persistent symptoms, contact your healthcare provider immediately. Regular monitoring and follow-up with your healthcare provider can help manage and mitigate potential side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Aredia:

Storage:

• In the Hospital or Clinic: Aredia is typically stored in a healthcare facility under controlled conditions. It is kept at a temperature between 2°C to 8°C (36°F to 46°F) and protected from light.
• At Home: You should not store Aredia at home, as it is usually administered in a medical setting.

Disposal:

• In the Medical Facility: Unused or expired Aredia should be disposed of according to the healthcare facility’s protocols for hazardous materials.
• Patient’s Role: If you are handling any unused medication or supplies, follow local guidelines for medication disposal, or consult your pharmacist for advice on safe disposal methods.

In case of emergency/overdose

• Contact Emergency Services: Call emergency medical services immediately.
• Provide Information: Be ready to provide details about the dose and timing of the overdose.
• Symptoms of Overdose: Symptoms may include severe bone, joint, or muscle pain, severe allergic reactions, or signs of kidney problems.

What other information should I know?

• Regular Monitoring: Regular follow-up appointments are necessary to monitor kidney function, calcium levels, and overall response to the treatment.
• Communication with Healthcare Provider: Always inform your healthcare provider about any other medications you are taking and any changes in your health status.
• Hydration: Stay well-hydrated to help minimize the risk of kidney issues.
• Dental Care: Maintain good oral hygiene and inform your dentist about your treatment with Aredia to prevent complications like osteonecrosis of the jaw.

Always follow your healthcare provider’s instructions and report any unusual symptoms or side effects promptly.