Why is this medication prescribed?

Apokyn (apomorphine) is primarily prescribed for the treatment of motor fluctuations in people with Parkinson’s disease. It’s used as a “rescue” medication to provide quick relief from off episodes, which are periods when the usual Parkinson’s disease symptoms return or worsen despite ongoing treatment. Apokyn can help improve motor symptoms such as tremor, rigidity, and bradykinesia (slowness of movement). It’s usually given as an injection under the skin and is often used in conjunction with other Parkinson’s disease medications to manage symptoms effectively.

How should this medicine be used?

Apokyn (generic name: apomorphine) is used to manage symptoms of Parkinson’s disease or Parkinson-like symptoms, particularly those related to “off” episodes where other medications may not be providing adequate control. Here’s how it should be used:

• Administration: Apokyn is administered via injection. It is usually given subcutaneously (under the skin) in the fatty tissue of the abdomen, thigh, or upper arm. The injections are typically administered by a healthcare provider, but in some cases, patients may be instructed on how to administer the medication themselves.
• Dosage: The dosage of Apokyn is individualized based on the patient’s needs and response. It’s important to follow the dosage instructions provided by your healthcare provider. The initial dose is often low, and it may be gradually adjusted to find the optimal dose.
• Injection Technique: Ensure you use a clean technique for injection. Rotate injection sites to avoid irritation. Follow any specific instructions provided by your healthcare provider for proper technique.
• Timing: Apokyn is used to manage acute symptoms and should be administered as needed. It is typically used during periods when other Parkinson’s medications are less effective.
• Monitoring: Regular follow-up with your healthcare provider is essential to monitor for effectiveness and any side effects. Your provider will adjust the dosage as necessary based on your response to the medication.
• Storage: Store Apokyn in the refrigerator (between 36°F and 46°F or 2°C and 8°C). Do not freeze it, and keep it in the original packaging to protect it from light.
• Disposal: Dispose of used needles and syringes in a proper sharps container, and follow any disposal guidelines provided by your healthcare provider or local regulations.
• Side Effects: Be aware of potential side effects such as nausea, dizziness, or sudden sleep attacks. If you experience severe side effects or signs of an allergic reaction, contact your healthcare provider immediately.

Always consult with your healthcare provider for personalized instructions and to address any concerns or questions you may have about using Apokyn.

Other uses for this medicine

• Rescue Medication: Apokyn is primarily used to manage off episodes in Parkinson’s disease, but it can also be used in cases where there is a sudden worsening of motor symptoms that are not controlled by other medications.
• Parkinson’s Disease Management: In addition to its primary use, Apokyn can be part of a broader management plan for Parkinson’s disease, helping to provide symptomatic relief in conjunction with other medications.

What special precautions should I follow?

When using Apokyn (apomorphine), it’s important to follow these special precautions:

• Medical History: Inform your healthcare provider if you have a history of heart problems, liver or kidney disease, low blood pressure, or a history of stroke. Apokyn can affect cardiovascular function and may not be suitable for everyone.
• Medication Interactions: Apokyn can interact with other medications, including those used to treat Parkinson’s disease, such as levodopa or other dopaminergic agents. Make sure to provide your healthcare provider with a complete list of all medications and supplements you are taking.
• Nausea and Vomiting: Apokyn can cause nausea and vomiting. Your healthcare provider may prescribe anti-nausea medication to help manage these side effects.
• Low Blood Pressure: Apokyn may cause a drop in blood pressure, which can lead to dizziness or fainting. Be cautious when standing up quickly from a sitting or lying position. If you experience symptoms of low blood pressure, such as lightheadedness or fainting, contact your healthcare provider.
• Sleep Attacks: Apokyn may cause sudden sleep attacks or drowsiness. Avoid driving or operating heavy machinery until you know how the medication affects you.
• Injection Site Reactions: Monitor the injection site for signs of irritation or infection, such as redness, swelling, or pain. Rotate injection sites to reduce the risk of these reactions.
• Mental Health: Apokyn can affect mood and behavior. Report any significant changes in mood or behavior, such as increased agitation or hallucinations, to your healthcare provider.
• Hydration and Diet: Maintain adequate hydration and follow any dietary recommendations provided by your healthcare provider. Apokyn should be used with caution in individuals with certain dietary restrictions.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using Apokyn with your healthcare provider.
• Emergency Situations: In case of severe allergic reactions or other serious side effects, seek emergency medical attention immediately.

Always follow the specific instructions provided by your healthcare provider and consult them with any concerns or questions regarding the use of Apokyn.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Apokyn. However, it’s important to maintain a balanced diet and stay hydrated. If you experience nausea or gastrointestinal issues, small, frequent meals or bland foods may help alleviate these symptoms. Always follow any additional advice provided by your healthcare provider.

What should I do if I forget a dose?

• Timing: If you realize you missed a dose, take it as soon as you remember, but only if it’s close to the time for your next dose.
• Avoid Doubling Up: Do not double the dose to make up for a missed one. This can increase the risk of side effects or complications.
• Consult Your Doctor: If you’re unsure about what to do or if you miss doses frequently, contact your healthcare provider for guidance on how to adjust your dosing schedule.

What side effects can this medication cause?

Apokyn (apomorphine) can cause a range of side effects. Some of the common and serious side effects include:

Common Side Effects:

• Nausea and Vomiting: These are among the most common side effects, particularly when starting the medication.
• Dizziness: You may experience lightheadedness or dizziness, which can affect your balance and coordination.
• Drowsiness: Apokyn can cause drowsiness or sleepiness, impacting your ability to perform activities requiring full alertness.
• Injection Site Reactions: Pain, redness, or swelling at the injection site can occur.

Less Common but Serious Side Effects:

• Hallucinations and Confusion: Apokyn may cause or worsen mental health symptoms, including hallucinations or confusion.
• Low Blood Pressure: Symptoms such as fainting, dizziness, or rapid heartbeat might indicate a drop in blood pressure.
• Sudden Sleep Attacks: Some people may experience sudden, uncontrollable episodes of sleep.
• Unusual Behavior: Changes in behavior or impulse control, including gambling or hypersexuality, have been reported.
• Severe Allergic Reactions: Symptoms might include severe rash, itching, swelling, or difficulty breathing.
• Severe Gastrointestinal Issues: Persistent nausea or vomiting that doesn’t improve may require medical attention.

If you experience any of these side effects, especially if they are severe or persistent, contact your healthcare provider promptly. They can provide guidance on how to manage these effects or adjust your treatment as needed.

What should I know about storage and disposal of this medication?

Storage of Apokyn:

• Store Apokyn at room temperature, away from heat and moisture. Do not store it in the refrigerator or freezer.
• Keep the medication in its original container to protect it from light.
• Ensure Apokyn is kept out of reach of children and pets to prevent accidental ingestion or misuse.

Disposal of Apokyn:

• Dispose of any unused or expired Apokyn according to local regulations or your pharmacy’s guidelines. Many pharmacies offer medication take-back programs.
• Do not flush Apokyn down the toilet or pour it into a drain, as this can harm the environment.

In case of emergency/overdose

• Emergency Contact: If you suspect an overdose or experience severe symptoms, contact emergency services immediately or go to the nearest emergency room.
• Symptoms of Overdose: Signs of overdose may include severe drowsiness, extreme dizziness, or loss of consciousness. Other symptoms may vary based on the dose taken and individual response.

What other information should I know?

• Monitoring: Regular follow-up appointments with your healthcare provider are essential to monitor your response to Apokyn and adjust the dose if necessary.
• Drug Interactions: Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.
• Pregnancy and Breastfeeding: Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the effects of Apokyn in these situations are not well-studied.
• Patient Education: Make sure you understand how to properly inject Apokyn and recognize the signs of side effects. Your healthcare provider can provide training and additional information.

Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about Apokyn.