Why is this medication prescribed?

Aminolevulinic acid (ALA) topical is primarily prescribed for two main conditions:

• Actinic Keratosis (AK): This is a precancerous skin condition caused by sun damage. ALA is used in photodynamic therapy (PDT) to treat these rough, scaly patches on the skin, reducing the risk of progression to skin cancer.
• Superficial Basal Cell Carcinoma (BCC): ALA is also used in PDT to treat this type of skin cancer when it’s confined to the surface of the skin.

In PDT, ALA is applied to the affected area and then activated with a special light. This process helps to destroy abnormal or cancerous cells while sparing the surrounding healthy tissue.

How should this medicine be used?

When using aminolevulinic acid (ALA) topical, follow these general steps:

• Preparation: Clean and dry the affected skin area thoroughly. Avoid using any moisturizers or other topical products before applying ALA.
• Application: Apply a thin, even layer of ALA topical to the targeted area as directed by your healthcare provider. Ensure that the application is uniform.
• Incubation: After applying ALA, it typically needs to be left on the skin for a specific period. This can range from 30 minutes to several hours, depending on the condition being treated. During this time, avoid exposing the treated area to light.
• Light Exposure: After the incubation period, the area is exposed to a specific wavelength of light, often using a blue or red light source. This step is crucial as it activates the ALA and helps destroy the abnormal cells.
• Post-Treatment Care: Follow your healthcare provider’s instructions for aftercare. This may include avoiding sun exposure, using gentle skin care products, and applying moisturizers or other recommended treatments.

Always follow the specific instructions given by your healthcare provider or outlined in the product’s labeling, as treatment protocols can vary. If you have any questions or concerns, it’s best to consult your healthcare provider.

Other uses for this medicine

Other Uses for Aminolevulinic Acid Topical:

• Acne: In some cases, ALA topical can be used off-label for treating severe acne, particularly in conjunction with photodynamic therapy. It helps to reduce inflammation and bacterial growth in the skin.
• Pre-cancerous Lesions: Besides actinic keratosis, ALA might be used for other pre-cancerous skin lesions.

What special precautions should I follow?

Special Precautions:

• Avoid Sun Exposure: After applying ALA and during the treatment period, avoid direct sunlight and bright lights. The area treated with ALA can become very sensitive to light.
• Follow Application Instructions: Apply ALA exactly as directed. Over-application or incorrect timing can affect the treatment’s effectiveness and increase the risk of side effects.
• Skin Sensitivity: Be aware that the treated area may become red, swollen, or irritated. This is a normal response, but if it seems excessive or problematic, consult your healthcare provider.
• Avoid Irritants: Refrain from using harsh skin products, such as those with retinoids or strong exfoliants, on the treated area unless advised by your healthcare provider.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using ALA with your healthcare provider.
• Allergies and Sensitivities: Inform your healthcare provider about any allergies or skin sensitivities you may have before starting treatment with ALA.

If you experience any unusual side effects or reactions, contact your healthcare provider promptly.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with the use of ALA topical. However, maintaining a balanced diet and staying hydrated can support overall skin health and recovery. Always follow any additional dietary advice provided by your healthcare provider if they give you specific instructions related to your treatment.

What should I do if I forget a dose?

If you miss a dose of ALA topical, apply it as soon as you remember, following the original instructions for application. If it’s close to the time of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Aminolevulinic acid (ALA) topical can cause various side effects, some of which are common and others that may be more severe. Here are potential side effects:

Common Side Effects:

• Redness: The treated area may become red, similar to a mild sunburn.
• Swelling: Mild swelling in the treated area can occur.
• Itching or Burning: You might experience itching, burning, or stinging sensations at the application site.
• Dryness and Peeling: The skin may become dry and start to peel after treatment.

Less Common but Serious Side Effects:

• Severe Skin Irritation: Intense redness, swelling, or pain that doesn’t improve with time.
• Blistering: Formation of blisters in the treated area.
• Infection: Signs of infection, such as increased redness, warmth, or pus.
• Allergic Reactions: Rarely, you might experience symptoms of an allergic reaction, such as rash, hives, itching, or difficulty breathing.

If you experience any of these more severe side effects or have concerns about your reaction to ALA topical, contact your healthcare provider promptly. Most side effects are temporary and resolve as the skin heals after treatment.

What should I know about storage and disposal of this medication?

Storage and Disposal of Aminolevulinic Acid Topical:

• Storage:
  • Temperature: Store ALA topical at room temperature, away from excess heat and moisture. Do not freeze.
  • Container: Keep it in its original container, tightly closed, to protect it from contamination and degradation.
  • Keep Out of Reach: Store it out of the reach of children and pets.
• Disposal:
  • Follow Local Guidelines: Dispose of ALA topical according to local regulations for pharmaceutical waste. Many areas have specific guidelines for disposing of medications.
  • Do Not Flush: Do not flush ALA topical down the toilet or pour it down the drain unless instructed to do so by local disposal guidelines.
  • Drug Take-Back Programs: If available, consider using a drug take-back program or facility for safe disposal.

In case of emergency/overdose

• Emergency: If you experience severe symptoms or an allergic reaction, seek medical attention immediately. This may include difficulty breathing, swelling of the face or throat, or severe skin irritation.
• Overdose: Although ALA is used topically, if you accidentally ingest it or apply an excessive amount, contact a poison control center or seek emergency medical help. Overdose symptoms might include severe skin reactions or other unusual symptoms.

What other information should I know?

• Follow Instructions: Always adhere to the specific application instructions provided by your healthcare provider or included with the medication.
• Avoid Interactions: Inform your healthcare provider about all other medications and treatments you are using, as interactions can occur.
• Consult Healthcare Provider: Regular follow-ups with your healthcare provider are important to monitor your progress and address any concerns.
• Documentation: Keep a record of your treatment schedule and any side effects experienced to discuss with your healthcare provider.

If you have any specific concerns or questions about your treatment, always consult your healthcare provider for personalized advice and guidance.