Why is this medication prescribed?

Alunbrig (Brigatinib) is prescribed primarily to treat non-small cell lung cancer (NSCLC) that is ALK-positive (anaplastic lymphoma kinase-positive). This type of lung cancer has a mutation in the ALK gene, which promotes cancer cell growth. Alunbrig works by inhibiting ALK and other kinases, slowing down or stopping the growth and spread of cancer cells.

It is usually prescribed for patients whose cancer has spread to other parts of the body (metastatic) and have either not responded to or have developed resistance to other ALK inhibitors like crizotinib.

How should this medicine be used?

Here’s a general guide on how Alunbrig is used:

• Dosage: Alunbrig is taken orally in the form of tablets. The typical initial dose is 90 mg once daily for the first seven days, followed by an increased dose of 180 mg once daily thereafter. The exact dosage and schedule may vary based on individual patient response and tolerance.
• Administration: Take the medication at the same time each day, with or without food. Swallow the tablets whole; do not crush, chew, or break them.
• Missed Dose: If a dose is missed or vomited, do not take an extra dose. Continue with the next scheduled dose.
• Precautions: Avoid grapefruit and grapefruit juice as they can increase the medication’s levels in your blood. Regular monitoring of liver function, blood pressure, and other health parameters is necessary. Use effective contraception during treatment and for some time after the last dose, as the drug can cause harm to a developing fetus.
• Special Considerations: Report any symptoms like shortness of breath, cough, or chest pain immediately, as these could indicate lung inflammation. Inform your doctor about all other medications and supplements you are taking, as Alunbrig can interact with several drugs.

Always follow your healthcare provider’s instructions and guidelines when taking Alunbrig.

Other uses for this medicine

Currently, Alunbrig is primarily approved and used for the treatment of ALK-positive non-small cell lung cancer (NSCLC). There are no widely recognized off-label uses or other approved indications beyond this type of cancer. However, clinical trials may explore its effectiveness for other cancers or conditions, so staying informed through updates from your healthcare provider is a good practice.

What special precautions should I follow?

Special Precautions for Alunbrig:

• Liver Function: Monitor liver function regularly. Alunbrig can affect liver enzymes, so your doctor will check for any abnormalities.
• Pulmonary Health: Watch for signs of lung problems such as shortness of breath, cough, or chest pain. Report these symptoms immediately as they could indicate a serious condition like pneumonitis.
• Heart Health: Alunbrig may cause heart issues, such as high blood pressure or slow heart rate. Your doctor will monitor your heart health regularly.
• Drug Interactions: Avoid grapefruit and grapefruit juice, which can increase the drug levels in your blood. Inform your healthcare provider about all other medications, supplements, and herbal products you are taking to avoid potential interactions.
• Pregnancy and Contraception: Alunbrig can be harmful to an unborn baby. Use effective contraception during treatment and for some time after the last dose. If you become pregnant while taking Alunbrig, inform your doctor immediately.
• Side Effects: Common side effects include nausea, diarrhea, fatigue, and headache. Report severe or persistent side effects to your doctor. Be aware of less common but serious side effects like severe allergic reactions, severe skin reactions, or vision changes.
• Dosage Adjustments: Your doctor may adjust your dose based on your response to the medication and any side effects you experience.

Always follow your healthcare provider’s guidance and report any new or worsening symptoms promptly.

What special dietary instructions should I follow?

• Grapefruit: Avoid grapefruit and grapefruit juice, as they can increase the risk of side effects by raising the level of Alunbrig in your blood.
• Food: Alunbrig can be taken with or without food. There are no specific dietary restrictions beyond avoiding grapefruit.

What should I do if I forget a dose?

• Missed Dose: If you miss a dose, take it as soon as you remember on the same day.
• Timing: If it’s almost time for your next dose, skip the missed dose. Do not double up or take extra doses to make up for a missed one.

What side effects can this medication cause?

Alunbrig (brigatinib) is used primarily for treating non-small cell lung cancer (NSCLC). Like any medication, it can have side effects. Some common and serious side effects of Alunbrig include:

Common Side Effects:

• Nausea
• Diarrhea
• Fatigue
• Headache
• Muscle pain or weakness
• Liver enzyme abnormalities

Serious Side Effects:

• Interstitial lung disease (ILD) or pneumonitis: Symptoms might include cough, shortness of breath, and fever.
• Bradycardia (slow heart rate): Can cause dizziness or fainting.
• Hypertension (high blood pressure)
• Severe allergic reactions: Symptoms might include rash, itching, swelling, or trouble breathing.
• Vision changes: Including blurred vision or other visual disturbances.
• Liver problems: Indicated by symptoms like jaundice (yellowing of the skin or eyes), dark urine, or persistent nausea.

It’s important to talk to your healthcare provider about any side effects you experience, as they can provide guidance on managing them or adjusting your treatment if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Alunbrig:

Storage:

• Store Alunbrig at room temperature, typically between 68°F to 77°F (20°C to 25°C).
• Keep it in a dry place away from moisture and heat.
• Keep the medication in its original container with the lid tightly closed.
• Keep it out of reach of children and pets.

Disposal:

• Do not dispose of Alunbrig in household trash or flush it down the toilet.
• Check if your local pharmacy or community has a drug take-back program or disposal location.
• Follow any specific disposal instructions provided with the medication or consult your pharmacist for advice on proper disposal.

In case of emergency/overdose

• Overdose Symptoms: Symptoms of an overdose may not always be obvious but could include severe side effects or an unusually high incidence of common side effects.
• Immediate Action: Contact emergency services or go to the nearest emergency room if you suspect an overdose.
• Information to Provide: Be prepared to provide information on the amount of Alunbrig taken, the time of ingestion, and any symptoms you are experiencing.

What other information should I know?

• Regular Monitoring: Regular check-ups with your healthcare provider are crucial for monitoring side effects and adjusting treatment as necessary.
• Medication Adherence: Take Alunbrig exactly as prescribed. Skipping doses or altering your dosage can affect the effectiveness of the treatment.
• Pregnancy and Breastfeeding: Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as Alunbrig can be harmful to a developing baby.
• Interactions with Other Drugs: Inform your healthcare provider of all medications, including over-the-counter drugs, supplements, and herbal products, to avoid interactions.
• Emergency Contact: Keep a list of emergency contacts, including your healthcare provider and local poison control, readily available.

Always follow your healthcare provider’s guidance and consult them if you have any concerns or need further information about Alunbri.