Why is this medication prescribed?

Akynzeo is a combination medication used to prevent nausea and vomiting caused by chemotherapy. It contains two active ingredients:

• Netupitant: a substance that blocks the action of certain chemicals in the brain that can trigger nausea and vomiting.
• Palonosetron: a medication that helps to block serotonin, a neurotransmitter that can also contribute to nausea and vomiting.

How should this medicine be used?

Akynzeo should be used according to your healthcare provider’s instructions, but general guidelines include:

• Timing: Akynzeo is typically taken orally as a single dose approximately 1 to 2 hours before chemotherapy begins.
• Form: It is available in capsule form.
• Administration: The capsule should be swallowed whole with water. Do not crush, chew, or open the capsule.
• Allergies: Inform your doctor if you have any known allergies to either netupitant, palonosetron, or any other medications.
• Medical History: Share your full medical history with your healthcare provider, especially if you have a history of liver problems or are taking other medications.
• Interactions: Be aware of potential drug interactions. Akynzeo can interact with other medications, so ensure your doctor is aware of all the medicines and supplements you are taking.

Always follow your healthcare provider’s instructions and the guidelines provided with your prescription. If you have any specific concerns or questions about using Akynzeo, it’s a good idea to consult your healthcare provider for personalized advice.

Other uses for this medicine

While Akynzeo is primarily prescribed to prevent nausea and vomiting associated with chemotherapy, it might also be used off-label for other types of severe nausea and vomiting. However, this use is less common and should be guided by a healthcare provider based on individual needs and circumstances.

What special precautions should I follow?

Special Precautions for Akynzeo:

• Allergies: If you have a known allergy to netupitant, palonosetron, or any other component of Akynzeo, you should not use it. Inform your healthcare provider about any allergies you have.
• Liver Function: Since netupitant can affect liver function, patients with liver impairment should use Akynzeo cautiously. Your healthcare provider may need to adjust the dose or monitor your liver function more closely.
• Drug Interactions: Akynzeo can interact with other medications, including certain antifungal drugs, antidepressants, and HIV medications. Inform your healthcare provider of all the medications, including over-the-counter drugs and supplements, that you are currently taking.
• Pregnancy and Breastfeeding: If you are pregnant or planning to become pregnant, discuss the potential risks and benefits of using Akynzeo with your healthcare provider. Similarly, if you are breastfeeding, consult your doctor to determine if Akynzeo is safe for you and your baby.
• Grapefruit Juice: Avoid consuming grapefruit juice while taking Akynzeo, as it can increase the levels of netupitant in your blood and potentially increase the risk of side effects.
• Other Health Conditions: If you have other health conditions, such as a history of heart problems or gastrointestinal issues, inform your healthcare provider. They can help determine if Akynzeo is appropriate for you and if any additional precautions are needed.

Always follow your healthcare provider’s recommendations and the instructions provided with your medication to ensure safe and effective use.

What special dietary instructions should I follow?

There are no specific dietary restrictions or instructions for using Akynzeo. However, maintaining a balanced diet and staying hydrated. Always consult your healthcare provider if you have concerns about dietary interactions. As mentioned, avoid grapefruit juice, as it can affect how Akynzeo is processed in your body.

What should I do if I forget a dose?

• Timing of Dose: Since Akynzeo is usually taken as a single dose before chemotherapy, missing a dose might not be applicable in most cases.
• Contact Healthcare Provider: If you miss the dose or are unsure about when to take it, contact your healthcare provider or pharmacist for specific instructions. They can advise on the best course of action based on your treatment schedule and individual circumstances.

What side effects can this medication cause?

Akynzeo, a combination of netupitant and palonosetron, is used to prevent nausea and vomiting caused by chemotherapy. While it’s generally well-tolerated, it can cause some side effects. Common ones include:

• Headache
• Fatigue
• Constipation
• Diarrhea

Less common but more serious side effects can include:

• Severe allergic reactions: rash, itching, swelling, severe dizziness, or trouble breathing.
• Heart rhythm problems: symptoms like rapid or irregular heartbeat.
• Liver problems: signs like jaundice (yellowing of the skin or eyes), dark urine, or abdominal pain.

Always consult your healthcare provider for personalized advice and report any unusual or severe symptoms you experience.

What should I know about storage and disposal of this medication?

Storage and Disposal of Akynzeo:

Storage:

• Temperature: Store Akynzeo at room temperature, away from excess heat and moisture. The typical range is between 20°C to 25°C (68°F to 77°F).
• Container: Keep the medication in its original container to protect it from light and moisture.

Disposal:

• Medication Take-Back Programs: Ideally, dispose of unused or expired Akynzeo through a drug take-back program. Many communities have designated locations or events for safe disposal of medications.
• Household Disposal: If no take-back programs are available, follow the instructions provided with your medication or consult your pharmacist. Typically, medications should not be flushed down the toilet or thrown away in the household trash unless specifically instructed.

In case of emergency/overdose

• If you suspect an overdose or experience severe symptoms, contact emergency services or go to the nearest emergency room immediately.
• Provide information about the medication, including the dosage taken and the time of ingestion, to medical personnel.
• Symptoms of an overdose might include severe drowsiness, dizziness, or other serious reactions. Immediate medical attention is essential.

What other information should I know?

• Follow Prescriptions: Always use Akynzeo exactly as prescribed by your healthcare provider. Do not adjust the dose or frequency without consulting them.
• Medical History: Provide a complete medical history to your healthcare provider, including any liver issues, other health conditions, or current medications.
• Regular Check-Ups: Regular appointments with your healthcare provider may be necessary to monitor your condition and any potential side effects.

Always consult your healthcare provider or pharmacist if you have questions or concerns about the storage, disposal, or any other aspects of using Akynzeo.