WARNING

AbobotulinumtoxinA, commonly known as Dysport, is used for various medical and cosmetic purposes, such as reducing muscle spasms and smoothing wrinkles. While it is generally safe when administered by a qualified professional, there are some risks associated with its use:

• Allergic Reactions: Rarely, patients might experience allergic reactions, including rash, itching, or swelling.
• Injection Site Reactions: Redness, swelling, pain, or bruising at the injection site can occur.
• Muscle Weakness: The toxin might spread beyond the targeted area, causing unintended muscle weakness or difficulty swallowing.
• Headache: Some people experience headaches following the injection.
• Flu-like Symptoms: Mild flu-like symptoms, such as fatigue or malaise, can occur.
• Vision Problems: In rare cases, patients might experience blurred vision or drooping eyelids.

It’s important to discuss these risks with your healthcare provider to ensure the benefits outweigh potential side effects for your specific situation.

Why is this medication prescribed?

AbobotulinumtoxinA, commonly known by its brand name Dysport, is a type of botulinum toxin used for several medical and cosmetic purposes. Here’s a detailed look at its uses and how it should be administered:

• Cervical Dystonia: AbobotulinumtoxinA is used to treat cervical dystonia, a condition where the neck muscles contract uncontrollably, causing the head to twist or tilt.
• Spasticity: It can help manage muscle spasticity in conditions such as stroke, cerebral palsy, or multiple sclerosis by relaxing overactive muscles.
• Facial Wrinkles: AbobotulinumtoxinA is commonly used to reduce the appearance of facial wrinkles, particularly around the forehead, eyes, and between the eyebrows.
• Blepharospasm: It treats blepharospasm, which involves involuntary blinking or eyelid spasms.

How should this medicine be used?

Administration and Use:

• Preparation: The medication should be prepared by a healthcare professional, usually by reconstituting the powder with a specific diluent. This ensures proper dosing and effectiveness.
• Injection: AbobotulinumtoxinA is injected directly into the muscles or specific areas as determined by the condition being treated. The number of injections and the dose depend on the specific condition and the patient’s needs.
• Frequency: The treatment schedule varies. For some conditions, injections might be needed every few months. For cosmetic purposes, treatments are typically repeated every 3 to 6 months.
• Post-Treatment Care: After the injection, patients are usually advised to avoid rubbing or massaging the treated area, as this can spread the toxin to unintended areas. They should also follow any additional guidance provided by their healthcare provider.
• Monitoring: Regular follow-up appointments are important to monitor the effectiveness of the treatment and make any necessary adjustments.

Always follow your healthcare provider’s instructions regarding the use of AbobotulinumtoxinA. They will provide specific guidance based on your individual health needs and treatment goals.

Other uses for this medicine

• Chronic Migraine: It may be used to prevent chronic migraines in adults.
• Overactive Bladder: Used in some cases to treat symptoms of an overactive bladder.
• Strabismus: Sometimes used for managing strabismus (misalignment of the eyes) in certain cases.

What special precautions should I follow?

Special Precautions:

• Allergic Reactions: If you have a known allergy to botulinum toxins or any components in the injection, this treatment should be avoided. Inform your healthcare provider about any allergies or previous adverse reactions.
• Neuromuscular Disorders: Inform your healthcare provider if you have neuromuscular disorders (e.g., myasthenia gravis, Lambert-Eaton syndrome) or a history of such conditions, as these may increase the risk of side effects.
• Pregnancy and Breastfeeding: The safety of AbobotulinumtoxinA during pregnancy and breastfeeding is not well-established. It should only be used if clearly needed and if the potential benefits outweigh the risks.
• Swallowing or Breathing Problems: Be cautious if you have conditions that affect swallowing or breathing, as botulinum toxins can potentially worsen these issues.
• Recent Surgery or Infection: Avoid using AbobotulinumtoxinA near recent surgeries or infections. Inform your healthcare provider if you have had recent surgery or if the area to be injected is inflamed or infected.
• Medications and Supplements: Let your healthcare provider know about all medications and supplements you are taking, as some drugs can interact with botulinum toxin treatments.
• Avoiding Spreading the Toxin: After the injection, avoid rubbing or massaging the treated area to prevent the toxin from spreading to unintended areas.
• Side Effects: Watch for potential side effects such as difficulty swallowing, breathing problems, or muscle weakness, and report any unusual symptoms to your healthcare provider promptly.
• Regular Follow-Up: Adhere to follow-up appointments to monitor the effectiveness and any side effects of the treatment. Adjustments to the dosage or treatment plan might be necessary based on your response.

Always follow your healthcare provider’s specific instructions and advice regarding the use of AbobotulinumtoxinA to ensure its effectiveness and safety for your particular situation.

What special dietary instructions should I follow?

• No Specific Dietary Restrictions: Generally, there are no specific dietary restrictions associated with AbobotulinumtoxinA. You can eat and drink normally unless otherwise directed by your healthcare provider.
• Hydration: It’s always good to stay well-hydrated, but there are no special dietary changes required related to this treatment.

What should I do if I forget a dose?

• Consult Your Healthcare Provider: Contact your healthcare provider if you miss a scheduled dose. They will advise you on whether to reschedule the missed dose or wait until the next scheduled treatment.
• Do Not Double Dose: Do not try to compensate for a missed dose by taking a double dose. This can increase the risk of side effects.
• Follow-Up Scheduling: Your healthcare provider will guide you on how to adjust your follow-up schedule if needed.

What side effects can this medication cause?

AbobotulinumtoxinA (Dysport) can cause a range of side effects, some of which are common and mild, while others may be more serious. Here’s an overview:

Common Side Effects:

• Injection Site Reactions: These can include pain, redness, swelling, or bruising at the site of the injection.
• Headache: Some people may experience headaches following the injection.
• Flu-like Symptoms: Mild flu-like symptoms such as tiredness, muscle aches, or a slight fever can occur.
• Dry Mouth: This is a less common but possible side effect.
• Nausea: Some individuals may feel nauseous after the injection.

Serious Side Effects:

• Muscle Weakness: Since the toxin affects muscle function, it can lead to unintended muscle weakness in areas other than the target muscles.
• Difficulty Swallowing: This is a serious side effect and can occur if the toxin affects muscles involved in swallowing.
• Difficulty Breathing: This is rare but serious and requires immediate medical attention.
• Vision Problems: Issues such as blurred vision or drooping eyelids may occur, particularly if the injection affects muscles around the eyes.
• Allergic Reactions: Rarely, people may experience severe allergic reactions such as rash, itching, swelling, severe dizziness, or trouble breathing.
• Spread of Toxin Effects: In rare cases, the effects of the toxin can spread beyond the injection site, causing symptoms similar to botulism (e.g., muscle weakness, difficulty swallowing, or respiratory problems).

It’s important to have a detailed discussion with your healthcare provider about the potential risks and benefits of AbobotulinumtoxinA before starting treatment. They can provide guidance tailored to your specific condition and health profile.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage:
  • Before Reconstitution: Store the lyophilized (powder) form of AbobotulinumtoxinA in a refrigerator at 2°C to 8°C (36°F to 46°F). It should be kept in its original package to protect it from light.
  • After Reconstitution: Once reconstituted with the provided diluent, the solution should be used immediately. If not used right away, it can typically be stored in the refrigerator (2°C to 8°C) for up to 24 hours. Do not freeze or store reconstituted solution at room temperature.
• Disposal:
  • Unused Medication: Dispose of any unused or expired AbobotulinumtoxinA according to your healthcare provider’s instructions. Follow local regulations for the disposal of medications.
  • Sharps Disposal: Needles and syringes used for administration should be placed in a proper sharps disposal container. Do not throw them in regular trash or flush them down the toilet.

In case of emergency/overdose

• Emergency:
  • Seek Immediate Help: If you experience severe symptoms such as difficulty breathing, swallowing, or severe muscle weakness, seek emergency medical attention immediately.
  • Contact Healthcare Provider: Contact your healthcare provider or local poison control center for guidance if you experience any severe side effects or symptoms you’re concerned about.
• Overdose:
  • Symptoms of Overdose: Overdose symptoms might include excessive muscle weakness, drooping eyelids, difficulty swallowing, or respiratory issues.
  • Immediate Action: If you suspect an overdose or experience severe symptoms, contact emergency medical services or go to the nearest emergency room right away. Provide information about the dosage and time of administration

What other information should I know?

• Medication Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as some may interact with AbobotulinumtoxinA.
• Regular Follow-Up: Regular follow-up visits are important to assess the effectiveness of the treatment and monitor for side effects. Make sure to attend these appointments as scheduled.
• Dosage and Treatment Plan: Adhere to the prescribed dosage and treatment plan. Do not adjust your dose or frequency without consulting your healthcare provider.
• Avoid Certain Activities: After receiving an injection, avoid activities that might put stress on the injected area, such as rubbing or massaging the site.
• Personal Health Conditions: Keep your healthcare provider informed of any changes in your health status, as this might affect your treatment plan.
• Emergency Contacts: Have contact information for your healthcare provider and emergency services readily available in case of unexpected reactions or emergencies.

Always consult your healthcare provider for any specific instructions or questions you may have regarding the use of AbobotulinumtoxinA. They will provide guidance tailored to your individual needs and circumstances.