WARNING

Taking Zyprexa Relprevv, like any medication, comes with potential risks and side effects. It’s essential to be aware of these risks and discuss them thoroughly with your healthcare provider before starting the medication. Some of the key risks associated with Zyprexa Relprevv include:

• Post-Injection Delirium/Sedation Syndrome (PDSS): Zyprexa Relprevv carries a risk of PDSS, a rare but serious condition characterized by sedation, confusion, and difficulty walking. Patients are typically monitored for at least three hours after each injection.
• Neuroleptic Malignant Syndrome (NMS): This is a potentially life-threatening condition associated with antipsychotic medications, including Zyprexa Relprevv. Symptoms include hyperthermia, muscle rigidity, altered mental status, and autonomic dysfunction.
• Metabolic Effects: Zyprexa Relprevv may lead to metabolic changes, including weight gain, increased cholesterol levels, and an elevated risk of diabetes. Regular monitoring of weight, blood sugar, and lipids is often necessary.
• Cardiovascular Effects: There is an increased risk of cardiovascular events, including orthostatic hypotension (a drop in blood pressure upon standing).
• Elderly Patients with Dementia-Related Psychosis: The use of Zyprexa Relprevv in elderly patients with dementia-related psychosis is associated with an increased risk of mortality.
• Blood Cell Abnormalities: Zyprexa Relprevv may rarely cause decreases in white blood cell count, increasing the risk of infections.
• Pregnancy and Breastfeeding: The use of Zyprexa Relprevv during pregnancy should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider. Olanzapine may pass into breast milk, and the decision to breastfeed should also be discussed with a healthcare professional.

It’s important to note that the decision to use Zyprexa Relprevv is based on a careful assessment of the individual’s psychiatric condition and the potential benefits of the medication in managing symptoms. Patients should have open and honest communication with their healthcare provider, report any side effects promptly, and attend regular follow-up appointments for monitoring. The information provided here is a brief overview, and individual risks can vary, so specific guidance should be obtained from a qualified healthcare professional.

Why is this medication prescribed?

Zyprexa Relprevv is a brand name for the extended-release injectable form of olanzapine, which is an atypical antipsychotic medication. It is primarily prescribed for the treatment of schizophrenia. Olanzapine, the active ingredient in Zyprexa Relprevv, helps to restore the balance of certain natural substances in the brain, particularly dopamine. Zyprexa Relprevv is approved for the treatment of schizophrenia in adults.

How should this medicine be used?

Here are some key points regarding the prescription and use of Zyprexa Relprevv:

Administration:

• Formulation: Zyprexa Relprevv is an extended-release formulation that is administered by injection.
• Frequency: It is typically administered once every two to four weeks. The specific dosing schedule may vary based on the individual’s response to the medication.
• Administration Site: The injection is usually given into the muscle (intramuscular injection), and the healthcare provider will determine the injection site.
• Dosage: The dosage will be determined by the healthcare provider based on the individual’s condition and response to treatment.

Important Considerations:

• Monitoring: Regular monitoring of patients receiving Zyprexa Relprevv is essential. This may include assessments of mental health, vital signs, and potential side effects.
• Not for Rapid Tranquilization: Zyprexa Relprevv is not intended for rapid tranquilization. It is a maintenance treatment for schizophrenia.
• Risk of Post-Injection Delirium/Sedation Syndrome (PDSS): There is a risk of a rare but serious condition called PDSS, which may occur after administration. Patients are usually observed by healthcare professionals for at least three hours after each injection.
• Patient Education: Patients should be educated about the potential risks and benefits of Zyprexa Relprevv, and they should seek medical attention if they experience any concerning symptoms or side effects.

It’s important to note that the above information provides a general overview, and specific instructions may vary based on an individual’s medical history and condition. Patients should always follow the advice and instructions of their healthcare providers when using Zyprexa Relprevv or any other medication.

Other uses for this medicine

While Zyprexa Relprevv is primarily approved for schizophrenia, healthcare providers sometimes prescribe medications off-label for conditions not officially approved by regulatory authorities. However, using a medication off-label should only be done under the guidance of a qualified healthcare professional who has carefully considered the potential risks and benefits.

What special precautions should I follow?

Special Precautions: When using Zyprexa Relprevv, several special precautions need to be considered:

• Post-Injection Delirium/Sedation Syndrome (PDSS): There is a risk of PDSS, a rare but serious condition that can occur after Zyprexa Relprevv administration. Patients are usually monitored for at least three hours post-injection in a healthcare setting.
• Cardiovascular and Metabolic Effects: Antipsychotic medications, including Zyprexa Relprevv, may be associated with cardiovascular and metabolic effects. Regular monitoring of blood pressure, blood sugar levels, and lipid profiles may be necessary.
• Elderly Patients with Dementia-Related Psychosis: Zyprexa Relprevv is not approved for the treatment of elderly patients with dementia-related psychosis due to an increased risk of mortality. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
• Neuroleptic Malignant Syndrome (NMS): NMS is a potentially life-threatening condition associated with antipsychotic medications, including Zyprexa Relprevv. Symptoms may include hyperthermia, muscle rigidity, altered mental status, and autonomic dysfunction. Immediate medical attention is required if these symptoms occur.
• Hyperglycemia and Diabetes: Zyprexa Relprevv may be associated with an increased risk of hyperglycemia and diabetes. Regular monitoring of blood glucose levels is advised, especially in patients with pre-existing diabetes or those at risk for diabetes.
• Weight Gain: Significant weight gain may occur with the use of Zyprexa Relprevv. Monitoring weight and addressing lifestyle factors is important.
• Pregnancy and Breastfeeding: The use of Zyprexa Relprevv during pregnancy should be carefully considered, and the potential benefits should outweigh the risks. It is important to discuss with a healthcare provider. Olanzapine may pass into breast milk, so breastfeeding while using Zyprexa Relprevv should be discussed with a healthcare professional.

It’s crucial for individuals prescribed Zyprexa Relprevv to have open and ongoing discussions with their healthcare provider about their medical history, potential side effects, and any concerns they may have. This information is not exhaustive, and specific precautions may vary based on individual health factors.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Zyprexa Relprevv. However, given that weight gain can be a side effect, maintaining a healthy and balanced diet is generally advisable. Individuals using Zyprexa Relprevv should discuss dietary considerations with their healthcare provider, especially if there are specific concerns about weight gain or metabolic effects.

What should I do if I forget a dose?

Since Zyprexa Relprevv is administered by healthcare professionals as an injectable, the responsibility for administration typically lies with the healthcare provider. However, if you have concerns or questions about the administration of your medication, it’s essential to contact your healthcare provider or the clinic where you receive your injections.

What side effects can this medication cause?

Zyprexa Relprevv, like any medication, may cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary. Additionally, the benefits of the medication in treating a serious condition should be carefully weighed against the potential risks. Here are some common and serious side effects associated with Zyprexa Relprevv:

Common Side Effects:

• Weight Gain: Zyprexa Relprevv is associated with a risk of weight gain. This can be significant in some individuals.
• Increased Appetite: Some people may experience an increase in appetite.
• Sleepiness or Sedation: Zyprexa Relprevv may cause drowsiness or sedation, affecting alertness.
• Constipation: Constipation is a common gastrointestinal side effect.
• Dry Mouth: Reduced saliva production leading to dry mouth.

Serious Side Effects:

• Post-Injection Delirium/Sedation Syndrome (PDSS): This is a rare but serious condition that may occur after Zyprexa Relprevv administration. Symptoms can include sedation, confusion, and difficulty walking.
• Neuroleptic Malignant Syndrome (NMS): A potentially life-threatening condition characterized by hyperthermia, muscle rigidity, altered mental status, and autonomic dysfunction.
• Metabolic Effects: Zyprexa Relprevv may lead to metabolic changes, including hyperglycemia (high blood sugar) and an increased risk of diabetes.
• Cardiovascular Effects: There may be an increased risk of cardiovascular events, including orthostatic hypotension (a drop in blood pressure upon standing).
• Increased Cholesterol Levels: Zyprexa Relprevv can lead to elevated cholesterol levels.
• Elderly Patients with Dementia-Related Psychosis: Use of antipsychotic drugs in elderly patients with dementia-related psychosis is associated with an increased risk of mortality.
• Leukopenia, Neutropenia, and Agranulocytosis: Rarely, Zyprexa Relprevv may cause decreases in white blood cell count, which could increase the risk of infections.

It’s important for individuals prescribed Zyprexa Relprevv to be aware of these potential side effects and report any unusual or severe symptoms to their healthcare provider promptly. Additionally, regular monitoring by healthcare professionals is typically recommended to assess the medication’s effectiveness and identify any emerging issues. If you have specific concerns or experience any side effects, consult your healthcare provider for guidance.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Zyprexa Relprevv is typically stored by healthcare professionals, and the storage conditions are crucial to maintain the effectiveness and safety of the medication. It’s important to follow the specific storage instructions provided by the manufacturer and the healthcare provider.
• Disposal: Since Zyprexa Relprevv is administered by healthcare professionals, disposal is typically handled by the healthcare facility or clinic. If you have any unused medication or concerns about disposal, it’s important to consult with your healthcare provider for guidance on proper disposal procedures. Do not dispose of medications in household trash or flush them down the toilet unless specifically instructed to do so.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek immediate medical attention. The symptoms of Zyprexa Relprevv overdose may include:

• Extreme drowsiness
• Uncontrollable movements or restlessness
• Agitation
• Fast or slow heartbeat
• Loss of consciousness

If someone is showing these symptoms or if you suspect an overdose, call emergency services (such as 911 in the United States) immediately.

What other information should I know?

• Regular Monitoring: Regular follow-up appointments with healthcare providers are essential to monitor the effectiveness of the medication and to check for any potential side effects or adverse reactions.
• Inform Healthcare Providers: Make sure to inform all healthcare providers involved in your care about the use of Zyprexa Relprevv, including dentists and other specialists. This is important for comprehensive and coordinated care.
• Inform About All Medications: Provide a comprehensive list of all medications, including prescription drugs, over-the-counter medications, and supplements, to your healthcare provider. This helps in preventing potential drug interactions.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Zyprexa Relprevv with your healthcare provider.
• Driving and Operating Machinery: Zyprexa Relprevv may cause sedation or drowsiness. Caution should be exercised when driving or operating machinery until the individual’s response to the medication is known.
• Allergic Reactions: If you have known allergies to olanzapine or any components of Zyprexa Relprevv, inform your healthcare provider. Seek immediate medical attention if you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing.

Always follow the guidance of your healthcare provider and carefully read the patient information leaflet provided with the medication for comprehensive information and instructions. If you have specific questions or concerns, discuss them with your healthcare team.