Why is this medication prescribed?

Zytiga, whose generic name is abiraterone acetate, is a medication used in the treatment of prostate cancer. It is specifically indicated for use in combination with prednisone in the treatment of metastatic castration-resistant prostate cancer (mCRPC). This means the cancer has spread to other parts of the body despite hormonal therapy to reduce testosterone levels.

Zytiga works by inhibiting the production of androgens (male hormones), including testosterone, which can fuel the growth of prostate cancer cells. It is often prescribed in conjunction with prednisone to manage side effects related to hormonal treatment and to enhance the effectiveness of Zytiga.

How should this medicine be used?

Here are general guidelines on how Zytiga is typically used:

• Dosage: Zytiga comes as a tablet to take by mouth on an empty stomach with water, 1 hour before or 2 hours after eating any food. This is because food can interfere with the absorption of the medication.
• Combination Therapy: Zytiga is usually prescribed in combination with prednisone, a corticosteroid. Prednisone is often taken along with Zytiga to manage certain side effects and to enhance the effectiveness of the treatment.
• Regular Monitoring: Patients taking Zytiga may require regular monitoring of their blood pressure, liver function, and other relevant laboratory tests to assess the drug’s impact and to manage any potential side effects.
• Follow Doctor’s Instructions: It is crucial for patients to follow their doctor’s instructions regarding the dosage and schedule. If there are any concerns or questions about the medication, it’s important to discuss them with the healthcare provider.
• Potential Side Effects: Like any medication, Zytiga can have side effects. Common side effects may include fatigue, joint swelling or discomfort, hot flashes, diarrhea, and elevated blood pressure. Serious side effects, such as liver problems, may also occur but are less common.
• Pregnancy and Breastfeeding: Zytiga can cause harm to a developing fetus, so it’s important to inform the healthcare provider if there is a possibility of pregnancy. Additionally, breastfeeding is not recommended during Zytiga treatment.

It’s important to note that individual cases may vary, and the above information is a general overview. Patients should always consult their healthcare provider for personalized advice based on their specific medical condition and needs. If you have been prescribed Zytiga, your doctor will provide detailed instructions tailored to your situation.

Other uses for this medicine

Zytiga (abiraterone acetate) is primarily indicated for the treatment of metastatic castration-resistant prostate cancer (mCRPC) when used in combination with prednisone. Zytiga does not have FDA approval for other uses. It’s crucial to use the medication only as prescribed by a healthcare professional.

What special precautions should I follow?

Special precautions and considerations when using Zytiga include:

• Hormonal Monitoring: Zytiga works by inhibiting the production of androgens. Regular monitoring of blood pressure, serum potassium levels, and liver function is typically recommended during treatment.
• Prednisone Use: Zytiga is usually prescribed in combination with prednisone to manage potential side effects. Prednisone is a corticosteroid that helps reduce inflammation and prevent certain side effects of Zytiga.
• Liver Function: Zytiga may cause liver function abnormalities. Regular monitoring of liver function tests is important during treatment. If you have pre-existing liver conditions, discuss this with your healthcare provider.
• Adrenal Insufficiency: Long-term use of Zytiga with prednisone may lead to adrenal insufficiency. Symptoms may include fatigue, muscle weakness, loss of appetite, and weight loss. Inform your healthcare provider if you experience such symptoms.
• Cardiovascular Effects: Zytiga has been associated with an increased risk of cardiovascular events. Inform your healthcare provider of any history of cardiovascular disease.
• Interactions with Other Medications: Zytiga can interact with certain medications, including strong CYP3A4 inducers and inhibitors. Inform your healthcare provider about all medications, including over-the-counter drugs and supplements, that you are taking.
• Pregnancy and Breastfeeding: Zytiga can cause harm to a developing fetus, and its use is not recommended during pregnancy. Women who are pregnant or may become pregnant should not handle Zytiga without protection, such as gloves. It is not known if abiraterone is excreted in breast milk, and breastfeeding is not recommended during treatment.
• Allergies: Inform your healthcare provider of any allergies to medications, including abiraterone acetate or prednisone.

Always follow your healthcare provider’s instructions regarding the use of Zytiga, and inform them of any changes in your health or any side effects you may experience. Regular follow-up appointments and monitoring are important during the course of treatment. As developments in medical knowledge may occur, it’s advisable to consult with your healthcare provider or a healthcare professional for the most current information.

What special dietary instructions should I follow?

There are no specific dietary restrictions for Zytiga. However, it is typically recommended to take Zytiga on an empty stomach, at least one hour before or two hours after a meal. Avoiding food during this time may enhance the absorption of the medication.

What should I do if I forget a dose?

If you forget to take a dose of Zytiga, it’s generally advised to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Zytiga (abiraterone acetate) can cause various side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary from person to person. Common side effects of Zytiga include:

• Adrenal Insufficiency: Long-term use of Zytiga with prednisone can lead to adrenal insufficiency. This may cause symptoms such as fatigue, muscle weakness, loss of appetite, and weight loss.
• Hypertension (High Blood Pressure): Zytiga can cause an increase in blood pressure. Regular monitoring of blood pressure is usually recommended during treatment.
• Hypokalemia (Low Potassium Levels): Zytiga may cause a decrease in potassium levels. Blood tests to monitor potassium levels may be performed.
• Fluid Retention: Some individuals may experience fluid retention, which can lead to swelling in the legs or other parts of the body.
• Liver Function Abnormalities: Zytiga can affect liver function, and elevated liver enzyme levels may occur. Regular monitoring of liver function is typically recommended.
• Cardiovascular Events: There may be an increased risk of cardiovascular events, including heart attacks and strokes, associated with the use of Zytiga.
• Joint Swelling or Discomfort: Some individuals may experience joint swelling or discomfort.
• Hot Flashes: Zytiga may cause hot flashes, similar to those experienced during menopause.
• Diarrhea: Diarrhea can occur as a side effect of Zytiga.
• Cough: A persistent cough can be a side effect of Zytiga.
• Fatigue: Fatigue and weakness may occur.

It’s essential to promptly report any side effects or changes in your health to your healthcare provider. They can provide guidance on managing side effects and may adjust the treatment plan if necessary.

In addition to the common side effects mentioned, there may be other less common or more severe side effects associated with Zytiga. It’s crucial to review the medication’s package insert or consult with a healthcare professional for a comprehensive understanding of potential side effects based on your individual health status.

If you experience severe or life-threatening side effects, such as difficulty breathing, chest pain, or signs of an allergic reaction (e.g., rash, swelling, severe dizziness), seek immediate medical attention.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zytiga:

• Storage: Store Zytiga at room temperature, away from light and moisture. Keep it in its original container, and ensure that it is tightly closed. Do not store it in the bathroom.
• Keep Out of Reach of Children: Store Zytiga in a location where it is not accessible to children or pets.
• Disposal: Dispose of unused or expired Zytiga properly according to local regulations and guidelines. Do not flush medications down the toilet unless specifically instructed to do so. Check with your pharmacist or healthcare provider for information on safe disposal.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms, seek emergency medical attention immediately. Symptoms of an overdose may include:

• Restlessness
• Rapid or irregular heartbeat
• Hallucinations
• Seizures
• Severe dizziness or fainting
• Difficulty breathing

What other information should I know?

• Allergic Reactions: If you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention.
• Medical Check-ups: Regularly check in with your healthcare provider to monitor the effectiveness of the medication and discuss any concerns or changes in your health.
• Interactions: Inform your healthcare provider about all medications, including over-the-counter drugs and herbal supplements, that you are taking to avoid potential interactions.
• Avoiding Driving or Hazardous Activities: Due to the potential for drowsiness or dizziness, be cautious when driving or operating machinery until you know how Zyrtec-D affects you.
• Alcohol and Other CNS Depressants: Limit or avoid alcohol consumption while taking Zyrtec-D, as it may enhance the sedative effects of the medication.
• Prolonged Use: Prolonged use of decongestants like pseudoephedrine can lead to rebound congestion. Use Zyrtec-D as directed by your healthcare provider.
• Non-prescription Use: Do not use Zyrtec-D for conditions for which it was not prescribed, and do not exceed the recommended dosage.

Always follow the specific instructions provided by your healthcare provider and on the medication label. If you have questions or concerns about your medication, consult your healthcare provider or pharmacist for guidance.