WARNING

Taking Zurampic (lesinurad) comes with certain risks and considerations. It’s important to note that not everyone will experience these risks, and the decision to use Zurampic should be made in consultation with a healthcare professional. Here’s a brief overview of the risks associated with Zurampic:

• Renal Function: Zurampic can affect kidney function. Regular monitoring of renal function is important, and if there is evidence of worsening renal function, dosage adjustments or discontinuation of Zurampic may be necessary.
• Kidney Stones: There is an increased risk of kidney stones with Zurampic. Adequate hydration is recommended to reduce this risk.
• Liver Function: Zurampic may affect liver function, and liver enzyme levels should be monitored during treatment.
• Gout Flares: Gout flares may occur during the early months of treatment with Zurampic. Prophylaxis with non-steroidal anti-inflammatory drugs (NSAIDs) or colchicine is recommended during the initiation of therapy.
• Interaction with Other Medications: Zurampic may interact with other medications. It’s important to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements.
• Allergic Reactions: Serious allergic reactions, though rare, may occur. Seek medical attention if you experience signs of an allergic reaction, such as rash, itching/swelling, severe dizziness, or difficulty breathing.
• Pregnancy and Breastfeeding: The safety of Zurampic during pregnancy and breastfeeding has not been established. The potential benefits should be weighed against potential risks, and its use during pregnancy is advised only if clearly needed.
• Cardiovascular Effects: Zurampic may lead to an increase in blood pressure. Blood pressure should be monitored regularly during treatment.

It’s important for individuals considering or using Zurampic to have a thorough discussion with their healthcare provider about their medical history, current medications, and any potential risks or concerns. This information is not exhaustive, and individual responses to medications can vary. Always follow your healthcare provider’s recommendations and report any unusual symptoms or side effects promptly.

Why is this medication prescribed?

Zurampic (lesinurad) is a medication used to treat gout in combination with a xanthine oxidase inhibitor (XOI). Gout is a type of arthritis that occurs when uric acid crystals build up in the joints, causing inflammation and pain. Zurampic works by helping the kidneys eliminate uric acid from the body, reducing the levels of uric acid in the blood and preventing the formation of uric acid crystals.

How should this medicine be used?

Zurampic (lesinurad) is a medication used in the treatment of gout, and it is typically prescribed in combination with a xanthine oxidase inhibitor (XOI) such as allopurinol. The dosage and administration of Zurampic can vary based on individual health factors, so it’s essential to follow the specific instructions provided by your healthcare provider and the information on the prescription label. However, here are some general guidelines on how Zurampic is commonly used:

• Dosage: The usual recommended dosage of Zurampic is 200 mg once daily, taken orally with or without food.
• Combination Therapy: Zurampic is often prescribed in combination with a xanthine oxidase inhibitor (XOI), such as allopurinol. This combination is used to help lower uric acid levels in the blood and reduce the frequency of gout attacks.
• Stay Hydrated: It’s important to drink plenty of fluids while taking Zurampic to help prevent kidney stones, a potential side effect of increased uric acid elimination.
• Regular Monitoring: Healthcare providers may monitor uric acid levels in the blood periodically to assess the effectiveness of the treatment.
• Follow Healthcare Provider’s Advice: Always follow your healthcare provider’s instructions regarding dosage adjustments, potential side effects, and any other specific recommendations related to your health.
• Caution with Renal Impairment: Zurampic is eliminated through the kidneys, so individuals with renal impairment may require dosage adjustments. If you have kidney problems, inform your healthcare provider so that they can determine the most appropriate dosage for you.

As always, it’s crucial to consult with your healthcare provider for personalized advice based on your specific health condition, medical history, and any other medications you may be taking. They can provide the most accurate and up-to-date information on the proper use of Zurampic in your particular case.

Other uses for this medicine

Zurampic is primarily indicated for the treatment of hyperuricemia associated with gout. It is not used as a standalone treatment but in combination with a xanthine oxidase inhibitor. As of last update, Zurampic is not approved for other uses. However, the information might have changed since then, and it’s always essential to consult with a healthcare professional or check the latest prescribing information for any updates.

What special precautions should I follow?

As for special precautions with Zurampic, it’s crucial to discuss your medical history, existing conditions, and any medications you are currently taking with your healthcare provider. Here are some general precautions associated with Zurampic:

• Kidney Function: Zurampic can affect kidney function. It is important to assess renal function before starting treatment and periodically during therapy. If there is evidence of worsening renal function, dosage adjustments or discontinuation of Zurampic may be necessary.
• Risk of Kidney Stones: The risk of kidney stones may be increased with Zurampic. Adequate hydration is recommended to reduce this risk.
• Liver Function: Zurampic may affect liver function, and liver enzyme levels should be monitored.
• Gout Flares: During the early months of treatment, gout flares may occur. Prophylaxis with non-steroidal anti-inflammatory drugs (NSAIDs) or colchicine is recommended during initiation of therapy.
• Drug Interactions: Zurampic may interact with other medications. Inform your healthcare provider about all the medications you are taking, including prescription and over-the-counter drugs, as well as herbal supplements.
• Pregnancy and Breastfeeding: The safety of Zurampic during pregnancy and breastfeeding has not been established. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Allergic Reactions: Seek medical attention if you experience signs of a serious allergic reaction, such as rash, itching/swelling, severe dizziness, or difficulty breathing.

Always follow your healthcare provider’s instructions and attend scheduled follow-up appointments to monitor your response to the medication and address any concerns. If you have specific questions or experience side effects while taking Zurampic, contact your healthcare provider promptly.

What special dietary instructions should I follow?

As of last update, there are no specific dietary restrictions associated with Zurampic. However, it’s important to maintain a healthy and balanced diet, especially if you are managing gout. Your healthcare provider may provide specific dietary recommendations based on your individual health needs.

What should I do if I forget a dose?

If you forget to take a dose of Zurampic, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions about missed doses or any other aspects of your medication regimen, contact your healthcare provider for guidance.

What side effects can this medication cause?

Zurampic (lesinurad) is a medication used in combination with other drugs to treat hyperuricemia (elevated levels of uric acid) associated with gout. It works by increasing the excretion of uric acid by the kidneys. As with any medication, Zurampic can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience effects that are not listed here. Common side effects of Zurampic include:

• Headache: Some people may experience headaches as a side effect of Zurampic.
• Flu-like symptoms: This can include symptoms such as fatigue, fever, and body aches.
• Gastrointestinal issues: Nausea and abdominal pain are reported in some cases.
• Increased blood creatinine levels: Zurampic can cause an increase in creatinine levels, which may indicate changes in kidney function.
• Increased blood pressure: Some individuals may experience elevated blood pressure while taking Zurampic.
• Joint and muscle pain: Pain in the joints and muscles has been reported as a side effect.
• Serious skin reactions: Although rare, serious skin reactions such as Stevens-Johnson syndrome have been reported.
• Liver function abnormalities: Zurampic may affect liver function, leading to changes in liver enzyme levels.

It’s important to contact your healthcare provider if you experience any unusual or severe side effects while taking Zurampic. Additionally, Zurampic may interact with other medications, so it’s essential to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements.

This information is not exhaustive, and individual responses to medications can vary. Always consult with your healthcare provider or pharmacist for the most up-to-date and personalized information regarding any medication, including Zurampic.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zurampic:

• Storage:
  • Store Zurampic at room temperature, away from excessive heat and moisture.
  • Keep the medication in its original packaging or container to protect it from light.
  • Follow any specific storage instructions provided by your pharmacist or healthcare provider.
• Disposal:
  • Dispose of unused or expired Zurampic properly and according to local regulations.
  • Do not flush medications down the toilet or pour them into drains unless instructed to do so.
  • Consult with your pharmacist or local waste disposal facility for guidance on the proper disposal of medications.

In case of emergency/overdose

In case of an emergency or suspected overdose, contact your local poison control center at 1-800-222-1222 (in the United States) or emergency medical services immediately. Overdose symptoms may include severe dizziness, nausea, vomiting, or other serious side effects. It’s important to seek medical attention promptly.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Take Zurampic exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting your healthcare provider.
• Regular Monitoring: Your healthcare provider may conduct regular blood tests to monitor uric acid levels, kidney function, and other parameters during treatment.
• Inform Healthcare Provider: Keep your healthcare provider informed about any changes in your health, including the development of new symptoms or side effects.
• Interactions with Other Medications: Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, as Zurampic may interact with certain medications.
• Allergic Reactions: Seek medical attention if you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Pregnancy and Breastfeeding: Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Zurampic in these situations is not well established.

Always consult with your healthcare provider or pharmacist for specific guidance based on your individual health status and any updates or changes in medical recommendations.