Why is this medication prescribed?

Zostrix HP (high potency) is a topical medication that contains capsaicin as its active ingredient. Capsaicin is the substance in chili peppers that gives them their heat. Zostrix HP is primarily prescribed for the management of pain associated with postherpetic neuralgia (PHN), a condition that can occur after an episode of shingles.

Shingles is caused by the reactivation of the varicella-zoster virus, the same virus that causes chickenpox. After a person recovers from chickenpox, the virus can remain dormant in nerve cells. In some cases, it can become active again later in life, leading to shingles. Postherpetic neuralgia is a complication of shingles and is characterized by persistent pain in the area where the shingles rash occurred.

The mechanism of action of Zostrix HP is believed to involve the depletion of substance P, a neurotransmitter involved in transmitting pain signals. By reducing substance P, Zostrix HP may help alleviate the pain associated with postherpetic neuralgia.

How should this medicine be used?

Here are general guidelines on how Zostrix HP should be used:

• Clean the affected area: Wash and dry the affected area before applying Zostrix HP.
• Apply a thin layer: Apply a thin layer of Zostrix HP to the affected area. Be cautious not to apply too much, as excessive application can lead to increased irritation.
• Frequency of application: Typically, Zostrix HP is applied three to four times a day, or as directed by a healthcare professional.
• Wash hands after application: After applying Zostrix HP, wash your hands thoroughly to avoid accidentally transferring the medication to other areas, especially sensitive areas like the eyes.
• Avoid contact with mucous membranes: Be careful to avoid contact with mucous membranes, including the eyes, nose, and mouth. If accidental contact occurs, rinse the affected area with water.
• Expect temporary burning sensation: It’s common to experience a temporary burning sensation after applying Zostrix HP. This is usually mild and tends to diminish with regular use. However, if the burning sensation is severe or persistent, consult with a healthcare professional.

It’s essential to use Zostrix HP as directed by a healthcare professional. Additionally, inform your healthcare provider about any other medications or medical conditions you have, as this can help avoid potential interactions or complications. As with any medication, consult with your healthcare provider before starting or stopping Zostrix HP.

Other uses for this medicine

While Zostrix HP is primarily prescribed for postherpetic neuralgia (PHN) associated with shingles, capsaicin, the active ingredient in Zostrix, has been investigated for its potential use in managing other types of pain. Some research and clinical trials have explored its application in conditions such as diabetic neuropathy, osteoarthritis, and neuropathic pain. However, it’s important to note that its efficacy in these conditions may vary, and the use of Zostrix HP for conditions other than postherpetic neuralgia should be determined by a healthcare professional.

What special precautions should I follow?

Here are some special precautions to consider when using Zostrix HP:

• Avoid contact with sensitive areas: Be cautious to avoid contact with sensitive areas such as the eyes, nose, mouth, and genitalia. Wash your hands thoroughly after applying the cream to prevent accidental transfer.
• Burning sensation: It’s common to experience a burning sensation after applying Zostrix HP. This sensation is usually temporary and tends to subside with regular use. If the burning is severe or persistent, consult with your healthcare provider.
• Skin irritation: Some individuals may experience skin irritation or redness at the application site. If this occurs, consult with your healthcare provider. Using too much Zostrix HP or applying it to broken or irritated skin can increase the risk of irritation.
• Allergic reactions: While rare, some individuals may be allergic to capsaicin. If you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek medical attention immediately.
• Interactions with other medications: Inform your healthcare provider about all medications you are currently taking, including over-the-counter drugs and herbal supplements. This information is important to avoid potential interactions with other medications.
• Pregnancy and breastfeeding: The safety of Zostrix HP during pregnancy and breastfeeding has not been well established. Consult with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Medical conditions: Inform your healthcare provider about any pre-existing medical conditions, especially skin conditions or allergies, before using Zostrix HP.

It’s crucial to follow the specific instructions provided by your healthcare provider or those outlined in the medication’s package insert. If you have any concerns or questions about using Zostrix HP, consult with your healthcare professional for personalized guidance based on your health status and medical history.

What special dietary instructions should I follow?

There are typically no specific dietary instructions associated with the use of Zostrix HP. However, it’s always a good idea to maintain a well-balanced diet and stay hydrated, as general good health practices can contribute to overall well-being.

What should I do if I forget a dose?

If you forget to apply a dose of Zostrix HP, apply it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for a missed dose.

What side effects can this medication cause?

Zostrix HP (high potency) is a topical medication containing capsaicin, which is derived from chili peppers. While generally considered safe, some individuals may experience side effects, especially during the initial period of use. Common side effects include:

• Burning Sensation: This is the most common side effect. After applying Zostrix HP, many individuals feel a temporary burning or warming sensation at the application site. This usually diminishes with continued use.
• Redness and Irritation: Some people may experience redness or irritation at the site of application. If this becomes severe or persistent, it’s advisable to consult with a healthcare professional.
• Itching or Discomfort: Itchiness or discomfort at the application site is also possible, particularly in the early stages of treatment.
• Dryness or Peeling: The skin in the treated area might become dry or peel, especially if Zostrix HP is used frequently.
• Increased Pain: Paradoxically, some individuals may experience an initial increase in pain before the pain relief occurs. This is often temporary.

Serious side effects are rare but can occur. If you experience any of the following, seek medical attention:

• Severe Burning or Pain: If the burning or pain is intolerable or becomes severe.
• Allergic Reaction: Signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Eye Irritation: If Zostrix HP accidentally comes into contact with the eyes, it can cause significant irritation. Rinse the eyes with water if this occurs.

It’s essential to follow the prescribed dosage and application instructions provided by your healthcare provider. If you have concerns about side effects or the use of Zostrix HP, consult with your healthcare professional. They can provide guidance based on your specific health status and medical history.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zostrix HP:

• Storage:
  • Store Zostrix HP at room temperature, away from excessive heat and direct sunlight.
  • Keep it in a cool, dry place.
  • Make sure the container is tightly closed.
  • Keep it out of reach of children.
• Disposal:
  • Dispose of Zostrix HP according to local regulations. Do not flush it down the toilet unless instructed to do so.
  • If you are unsure about how to dispose of Zostrix HP, consult with your pharmacist or healthcare provider.

In case of emergency/overdose

In the case of an emergency or suspected overdose of Zostrix HP, contact your local poison control center or seek emergency medical attention immediately. Overdose symptoms may include severe burning or pain that is intolerable.

What other information should I know?

• Application Precautions: Avoid applying Zostrix HP to broken or irritated skin. Wash hands thoroughly after applying Zostrix HP to avoid accidental contact with sensitive areas such as the eyes.
• Burning Sensation: A temporary burning sensation is common after applying Zostrix HP, especially during the initial period of use. This is generally mild and tends to diminish with regular use.
• Allergic Reactions: If you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek medical attention.
• Avoid Contact with Mucous Membranes: Be cautious to avoid contact with mucous membranes, including the eyes, nose, and mouth.
• Regular Use: The effectiveness of Zostrix HP is often seen with regular and consistent use over time. It may take several weeks for the full benefits to be realized.
• Medical History: Inform your healthcare provider about your medical history, especially if you have any skin conditions or allergies.

Always use Zostrix HP as directed by your healthcare provider. If you have any concerns or questions about its use, consult with your healthcare professional for personalized guidance based on your health status and medical history.