WARNING

Taking Zortress (everolimus) comes with potential risks, especially as it is an immunosuppressant medication used to prevent organ rejection in transplant recipients. Some of the risks associated with Zortress include:

• Increased Risk of Infections: Zortress suppresses the immune system, which increases the risk of infections. Serious infections, including bacterial, viral, and fungal infections, can occur.
• Delayed Wound Healing: Zortress may slow down the healing of wounds, which can be a concern after surgery or injury.
• High Blood Sugar Levels and Diabetes: Zortress may lead to elevated blood sugar levels and, in some cases, new-onset diabetes.
• High Cholesterol and Triglycerides: Zortress may increase lipid levels in the blood, leading to high cholesterol and triglycerides.
• Kidney Problems: Zortress can affect kidney function, and in some cases, it may lead to renal impairment.
• Lung or Breathing Problems: Interstitial lung disease, a serious but rare side effect, has been reported.
• Liver Function Abnormalities:ortress can affect liver function, and periodic liver function tests are often recommended.
• Allergic Reactions: In rare cases, severe allergic reactions can occur.
• Increased Risk of Tumors: Some studies suggest an increased risk of certain types of tumors, including non-infectious pneumonitis and skin cancers.
• Other Side Effects: Common side effects include mouth sores, rash, diarrhea, headache, and fatigue.

It’s important for individuals taking Zortress to be aware of these potential risks and to report any unusual or severe symptoms to their healthcare provider promptly. Regular monitoring, including blood tests, is often part of the treatment plan to detect and manage potential side effects. The benefits of preventing organ rejection need to be weighed against the potential risks, and decisions about treatment are made on an individual basis in consultation with healthcare professionals. Patients should not discontinue or adjust their medication without consulting their healthcare provider.

Why is this medication prescribed?

Zortress (everolimus) is prescribed primarily as an immunosuppressant medication. Immunosuppressants are drugs that suppress or weaken the activity of the immune system. Zortress is specifically used in the context of organ transplantation to prevent rejection of the transplanted organ.

When an individual undergoes an organ transplant, the body’s immune system recognizes the transplanted organ as foreign and may mount an immune response to reject it. Immunosuppressive medications, like Zortress, are prescribed to dampen the immune system’s response, thereby reducing the risk of rejection.

Key points regarding why Zortress is prescribed include:

• Organ Transplantation: Zortress is commonly used in kidney transplantation. It may also be used in some cases for heart or liver transplantation. After the transplant surgery, patients are at risk of the immune system recognizing the new organ as foreign and attacking it. Zortress helps to prevent this rejection.
• Mechanism of Action: Zortress inhibits a protein called mTOR (mammalian target of rapamycin), which plays a role in the activation of immune cells. By inhibiting mTOR, Zortress interferes with certain pathways in the immune system, reducing the immune response directed against the transplanted organ.
• Combination Therapy: Zortress is often used in combination with other immunosuppressive medications to achieve the desired level of immunosuppression. The specific combination of medications can vary depending on the transplant type and the individual patient’s needs.

How should this medicine be used?

The usage of Zortress (everolimus) should be based on the specific instructions provided by the prescribing healthcare professional. However, here are some general guidelines on how Zortress is typically used:

• Dosage: The dosage of Zortress can vary depending on factors such as the type of organ transplant, the patient’s medical history, and other medications they may be taking. The healthcare provider will determine the appropriate dosage based on individual circumstances.
• Administration: Zortress is usually taken orally, with or without food. It’s important to follow the healthcare provider’s instructions regarding the timing and conditions of administration. Some people may be instructed to take it at the same time each day.
• Consistency: It’s crucial to take Zortress consistently to maintain a steady level of the medication in the body. Missing doses or taking extra doses can impact the effectiveness of the treatment.
• Monitoring: Patients taking Zortress are typically monitored closely by healthcare providers. This may involve regular blood tests to check the level of the medication in the blood and to assess how well the body is responding to the treatment. Monitoring is also important for detecting and managing any potential side effects.
• Interaction with Other Medications: Zortress may interact with other medications, so it’s important for the healthcare provider to be aware of all medications, including over-the-counter drugs and supplements, that the patient is taking. Adjustments to the treatment plan may be necessary based on these interactions.
• Adverse Effects: Patients should be aware of potential side effects of Zortress and report any unusual or severe symptoms to their healthcare provider promptly. Common side effects may include mouth sores, rash, diarrhea, and changes in blood cell counts.
• Pregnancy and Contraception: Zortress can harm an unborn baby, so it’s important for individuals of childbearing age to use effective contraception during treatment. Patients should discuss family planning and contraception with their healthcare provider.

It’s important to note that the information provided here is general, and individual patient instructions may vary. Patients should follow the specific guidance given by their healthcare provider and contact them with any questions or concerns about the use of Zortress. Additionally, because medical information can change, it’s advisable to consult healthcare professionals for the most current guidance.

Other uses for this medicine

Zortress (everolimus) is primarily used as an immunosuppressant medication in the context of organ transplantation to prevent rejection. However, it’s worth noting that medications, including Zortress, can sometimes be prescribed “off-label” for uses other than those officially approved by regulatory authorities. If there have been any updates or changes in approved uses since then, it would be important to consult with a healthcare professional or refer to more recent medical literature.

What special precautions should I follow?

Here are some special precautions and considerations for Zortress:

• Pregnancy and Contraception: Zortress can harm a developing fetus, so it’s crucial for individuals of childbearing potential to use effective contraception during treatment. Women should not become pregnant while taking Zortress and for a certain period after discontinuation. It’s essential to discuss family planning and contraception with the healthcare provider.
• Breastfeeding: It is not recommended to breastfeed while taking Zortress. The potential risks to the nursing infant should be weighed against the benefits of the drug, and the decision should be made in consultation with the healthcare provider.
• Infections: Immunosuppressive medications, including Zortress, can increase the risk of infections. Patients should be vigilant about signs of infection and report any symptoms to their healthcare provider promptly.
• Monitoring: Regular monitoring, including blood tests, is often required to assess the levels of Zortress in the blood and to monitor for any potential side effects or complications.
• Interactions: Zortress may interact with other medications. It’s important for the healthcare provider to be aware of all medications, including over-the-counter drugs and supplements, that the patient is taking.
• Liver and Kidney Function: Zortress is metabolized by the liver, and its dosage may need adjustment in individuals with impaired liver function. Individuals with impaired kidney function may also require dosage adjustments.
• Wound Healing: Zortress may affect wound healing. Patients undergoing surgery or dental procedures should inform their healthcare providers about their Zortress treatment.
• Lipid Levels: Zortress may increase lipid (fat) levels in the blood. Regular monitoring of lipid levels may be necessary.

It’s crucial for individuals prescribed Zortress to communicate openly with their healthcare providers about their medical history, current medications, and any concerns or side effects they may be experiencing. As medical information can change, it’s advisable to consult healthcare professionals for the most current guidance and information regarding the use of Zortress.

What special dietary instructions should I follow?

• Food Intake: Zorprin can be taken with or without food. Taking it with food or milk may help reduce the risk of stomach upset.
• Gastric Irritation: If you have a history of stomach problems or gastric irritation, discuss this with your healthcare provider. They may recommend specific dietary modifications or additional medications to protect your stomach lining.

What should I do if I forget a dose?

• Missed Dose: If you forget to take a dose, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Double Dosing: Do not take a double dose to make up for a missed one. Taking more than the prescribed amount can increase the risk of side effects without providing additional benefits.
• Consult Your Healthcare Provider: If you have questions about missed doses or if you are unsure about what to do, contact your healthcare provider for guidance.

What side effects can this medication cause?

Zortress (everolimus) is an immunosuppressive medication commonly used in the context of organ transplantation to prevent rejection. Like any medication, Zortress can cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary. Common and serious side effects associated with Zortress include:

Common Side Effects:

• Mouth Sores: Some individuals may experience mouth sores or ulcers.
• Rash: Skin rash is a relatively common side effect.
• Diarrhea: Gastrointestinal disturbances, including diarrhea, can occur.
• High Blood Pressure: Zortress may lead to an increase in blood pressure.
• Headache: Headaches are a reported side effect.
• Fatigue: Some people may experience fatigue or weakness.
• Changes in Blood Cell Counts: Zortress can affect blood cell counts, leading to anemia, leukopenia (low white blood cell count), or thrombocytopenia (low platelet count).

Serious Side Effects:

• Increased Risk of Infections: Zortress suppresses the immune system, increasing the risk of infections. Serious infections, including bacterial, viral, and fungal infections, can occur.
• Delayed Wound Healing: Zortress may slow down the healing of wounds, which can be a concern after surgery or injury.
• High Blood Sugar Levels: Zortress may lead to elevated blood sugar levels, and in some cases, new-onset diabetes.
• High Cholesterol and Triglycerides: Zortress may increase lipid levels in the blood, leading to high cholesterol and triglycerides.
• Kidney Problems: Zortress can affect kidney function, and in some cases, it may lead to renal impairment.
• Lung or Breathing Problems: Interstitial lung disease, a serious but rare side effect, has been reported.
• Liver Function Abnormalities: Zortress can affect liver function, and periodic liver function tests are often recommended.
• Allergic Reactions: In rare cases, severe allergic reactions can occur.

It’s crucial for individuals taking Zortress to be aware of potential side effects and report any unusual or severe symptoms to their healthcare provider promptly. Regular monitoring, including blood tests, is often part of the treatment plan to detect and manage potential side effects. Patients should not discontinue or adjust their medication without consulting their healthcare provider, and any concerns or questions should be discussed with the medical team. It’s advisable to consult healthcare professionals or refer to more recent sources for the latest information on Zortress side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zortress:

• Storage:
  • Store Zortress at room temperature, away from light and moisture.
  • Keep it in the original container with the lid tightly closed.
  • Do not store Zortress in the bathroom, where it may be exposed to moisture.
• Disposal:
  • Dispose of unused or expired medications properly. Check with your healthcare provider or pharmacist for guidance on the appropriate disposal method.
  • Do not flush medications down the toilet unless specifically instructed to do so.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms, seek emergency medical attention or contact your local poison control center immediately. Overdose symptoms may include:

• Severe dizziness or fainting
• Uncontrolled or rapid breathing
• Severe stomach pain
• Unexplained bleeding or bruising

What other information should I know?

• Regular Monitoring: Regular blood tests are often required to monitor Zortress levels, assess the immune function, and detect any potential side effects.
• Medical and Laboratory Tests: Keep appointments for medical and laboratory tests as advised by your healthcare provider.
• Follow Healthcare Provider’s Instructions: Follow your healthcare provider’s instructions regarding medication dosage, administration, and any dietary or lifestyle restrictions.
• Interactions: Inform your healthcare provider about all medications, including prescription, over-the-counter drugs, and supplements, to avoid potential interactions.
• Avoid Grapefruit: Avoid consuming grapefruit or grapefruit juice while taking Zortress, as it can interact with the medication.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Avoid Alcohol: Limit or avoid alcohol consumption, as it may interact with Zortress.
• Wound Healing: Inform healthcare providers about Zortress treatment before surgery or dental procedures, as it may affect wound healing.
• Consult Healthcare Provider: If you have any concerns, questions, or experience side effects, consult your healthcare provider promptly.
• Medical Alert ID: Consider wearing a medical alert ID bracelet or necklace to inform emergency medical personnel that you are taking Zortress.

Always consult your healthcare provider or pharmacist for specific guidance tailored to your individual health needs and circumstances. This information is general in nature and may not cover all aspects of Zortress use.