WARNING

Taking Zontivity (vorapaxar) comes with certain risks, and it’s crucial for individuals to be aware of them. Here is a brief overview of some key risks associated with Zontivity:

• Bleeding Risk: Zontivity increases the risk of bleeding, and this can range from mild bruising to severe and potentially life-threatening bleeding events. The risk is particularly elevated in individuals with a history of bleeding disorders or those taking other medications that affect blood clotting.
• Contraindications: Zontivity is contraindicated in individuals with a history of stroke, transient ischemic attack (TIA), intracranial bleeding, or active pathological bleeding. It should not be used in individuals at high risk of bleeding.
• Gastrointestinal Bleeding: Zontivity may increase the risk of gastrointestinal bleeding, and individuals may experience symptoms such as black or bloody stools, which require immediate medical attention.
• Cardiovascular Events: In some cases, Zontivity may increase the risk of serious cardiovascular events, such as heart attack or stroke. It is typically prescribed to individuals at high risk of these events.
• Liver Function: Zontivity is metabolized in the liver, and individuals with liver impairment may require dosage adjustments. Regular monitoring of liver function may be recommended.
• Joint Pain: Some individuals may experience joint pain or back pain as a side effect of Zontivity.

It’s important for individuals taking Zontivity to communicate openly with their healthcare provider about their medical history, existing conditions, and any medications or supplements they are taking. This helps in assessing the overall risk-benefit profile for each individual. The decision to prescribe Zontivity should be made in consideration of the patient’s cardiovascular risk and potential bleeding risk.

If you are prescribed Zontivity or have concerns about its risks and benefits, consult your healthcare provider. They can provide personalized information based on your health status and guide you on the appropriate use and monitoring while on this medication.

Why is this medication prescribed?

Zontivity (vorapaxar) is a prescription medication used to reduce the risk of heart attack, stroke, cardiovascular death, and need for procedures to restore the blood flow to the heart in patients with a history of heart attack or blockages in the blood vessels supplying the legs or feet. It is typically prescribed in combination with other antiplatelet agents and standard care.

Zontivity is an antiplatelet medication that works by inhibiting the action of a substance called thrombin, which is involved in blood clot formation. By reducing the tendency of blood platelets to stick together and form clots, Zontivity helps prevent the occurrence of cardiovascular events.

How should this medicine be used?

Zontivity is an oral medication, usually taken once daily with or without food. It’s commonly prescribed as part of a comprehensive cardiovascular risk reduction strategy, especially in individuals with a history of heart attack, peripheral artery disease, or other cardiovascular conditions.

Here are some general guidelines for using Zontivity:

• Dosage: The typical recommended dose is one tablet (2.08 mg) taken orally once daily.
• Timing: Zontivity can be taken with or without food. It’s important to take it consistently at the same time each day.
• Follow Healthcare Provider’s Instructions: Always follow the specific instructions provided by your healthcare provider. They will determine the appropriate dosage and duration of treatment based on your individual medical history, risk factors, and overall health.
• Combination Therapy: Zontivity is often prescribed in combination with other antiplatelet medications or standard care for cardiovascular risk reduction. It may be part of a regimen that includes aspirin or other medications.
• Do Not Stop Abruptly: It’s crucial not to stop taking Zontivity or adjust the dosage without consulting your healthcare provider. Abruptly stopping antiplatelet medications can increase the risk of cardiovascular events.
• Inform Healthcare Providers: Make sure to inform all healthcare providers involved in your care, including dentists and surgeons, that you are taking Zontivity. This is important because Zontivity affects blood clotting, and adjustments may be needed if you are undergoing surgical procedures.
• Monitoring: Regular follow-up appointments with your healthcare provider are important to monitor the effectiveness of the medication and assess any potential side effects or complications.

As always, individual circumstances may vary, and it’s crucial to consult with your healthcare provider for personalized advice regarding the use of Zontivity. If you have specific questions about your prescription, dosing, or any concerns, your healthcare provider or pharmacist is the best resource for guidance.

Other uses for this medicine

As for other uses, Zontivity is specifically indicated for reducing the risk of thrombotic cardiovascular events, and its use should be guided by a healthcare professional based on individual patient characteristics and medical history. It is not typically prescribed for conditions other than those related to cardiovascular risk reduction.

What special precautions should I follow?

Special precautions and considerations when using Zontivity include:

• Bleeding Risk: Zontivity increases the risk of bleeding, including serious and sometimes fatal bleeding. It’s important to inform your healthcare provider if you have a history of bleeding disorders or other conditions that may increase the risk of bleeding.
• Contraindications: Zontivity is contraindicated in individuals with a history of stroke, transient ischemic attack (TIA), intracranial bleeding, or active pathological bleeding.
• Interactions with Other Medications: Zontivity may interact with other medications, including other antiplatelet agents and anticoagulants. Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements.
• Liver Function: Zontivity is metabolized in the liver, so individuals with liver impairment may require dosage adjustments. Your healthcare provider will assess your liver function before prescribing Zontivity.
• Surgery and Procedures: Zontivity affects blood clotting, and it’s important to inform healthcare providers, including dentists and surgeons, about your medication before undergoing any surgical procedures.
• Pregnancy and Breastfeeding: The safety of Zontivity during pregnancy and breastfeeding is not well-established. Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Monitoring: Regular monitoring, including blood tests, may be conducted by your healthcare provider to assess the safety and effectiveness of Zontivity.

Always follow your healthcare provider’s instructions and inform them of any changes in your health status or if you experience any unusual symptoms. This information is based on knowledge, and there may have been updates or changes since then. If you have specific concerns or questions about Zontivity, it’s best to consult with your healthcare provider or pharmacist.

What special dietary instructions should I follow?

• There are no specific dietary restrictions associated with Zontivity. However, maintaining a healthy and balanced diet is generally important for overall cardiovascular health.
• If you have concerns about how your diet may interact with your medications, it’s advisable to discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

• If you forget to take a dose of Zontivity, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for a missed one.
• If you are uncertain about what to do, or if you have missed multiple doses, contact your healthcare provider for guidance.

What side effects can this medication cause?

Zontivity (vorapaxar) may cause side effects, and it’s important to be aware of them. Keep in mind that not everyone will experience these side effects, and some individuals may tolerate the medication well. Common side effects and adverse reactions associated with Zontivity include:

• Bleeding: Zontivity increases the risk of bleeding, and bleeding events can range from mild to severe. This may include bleeding in the gastrointestinal tract, intracranial bleeding, and other types of bleeding.
• Allergic Reactions: Some people may experience allergic reactions to Zontivity, including rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you experience these symptoms.
• Liver Enzyme Abnormalities: Zontivity may lead to increases in liver enzyme levels. Regular monitoring of liver function may be recommended by your healthcare provider.
• Serious Cardiovascular Events: In some cases, Zontivity may increase the risk of serious cardiovascular events, such as heart attack or stroke.
• Anemia: A decrease in red blood cell count (anemia) may occur in some individuals.
• Joint Pain: Some people may experience joint pain or back pain.

It’s crucial to promptly report any unusual or severe symptoms to your healthcare provider. If you experience signs of bleeding, such as persistent or severe nosebleeds, blood in the urine or stool, unusually heavy menstrual bleeding, or easy bruising, seek medical attention promptly.

Additionally, inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, as there may be interactions with Zontivity that could increase the risk of bleeding or other side effects.

Remember, this is not an exhaustive list of side effects, and individual responses to medication can vary. If you have specific concerns about the side effects of Zontivity, discuss them with your healthcare provider. They can provide you with more personalized information based on your health history and current medications.

What should I know about storage and disposal of this medication?

Here are some important considerations regarding the storage and disposal for Zontivity (vorapaxar):

Storage:

• Room Temperature: Store Zontivity at room temperature, away from excessive heat and moisture.
• Keep Container Closed: Keep the medication in its original container with the lid tightly closed.
• Away from Children and Pets: Store Zontivity in a location that is out of reach of children and pets.

Disposal:

• Follow Local Guidelines: Dispose of Zontivity according to local guidelines and regulations for the disposal of medications. Do not flush it down the toilet unless specifically instructed to do so.
• Take-Back Programs: Check if there are any medication take-back programs in your area. These programs provide a safe way to dispose of unused or expired medications.
• Ask Your Pharmacist: Your pharmacist can provide guidance on the proper disposal of medications.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek medical attention immediately. Symptoms of an overdose or adverse reaction may include severe bleeding, signs of an allergic reaction, or other serious side effects. Call your local emergency number or go to the nearest emergency room.

What other information should I know?

• Regular Monitoring: Your healthcare provider may conduct regular monitoring, including blood tests, to assess the safety and effectiveness of Zontivity.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care, including dentists and surgeons, that you are taking Zontivity. This is important because Zontivity affects blood clotting, and adjustments may be needed if you are undergoing surgical procedures.
• Medication Interactions: Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, as Zontivity may interact with other medications.
• Patient Assistance Programs: If you have difficulty affording your medication, inquire about patient assistance programs or discount programs that may be available.
• Regular Follow-Up: Attend regular follow-up appointments with your healthcare provider to discuss your progress, any side effects, and to ensure that the medication is effectively managing your condition.

Always follow the specific instructions provided by your healthcare provider and consult them if you have any questions or concerns about Zontivity. This information is intended as a general guide, and individual circumstances may vary.