WARNING

Zevalin, like any medical treatment, carries potential risks. Here is a brief overview of some of the risks associated with taking Zevalin:

• Radiation Exposure: Zevalin contains a radioactive substance (yttrium-90), and exposure to radiation is an inherent risk. Special precautions are taken to minimize exposure to healthcare providers and others.
• Hematologic Effects: Zevalin can affect blood cell counts, leading to a decrease in white blood cells, red blood cells, and platelets. This can result in an increased risk of infection, anemia, and bleeding.
• Infections: Zevalin can suppress the immune system, making patients more susceptible to infections. Serious infections can occur.
• Infusion-Related Reactions: Patients may experience reactions during or shortly after the infusion, including fever, chills, nausea, vomiting, and headache. These reactions are usually mild to moderate.
• Allergic Reactions: Serious allergic reactions to Zevalin, including anaphylaxis, have been reported. Patients with a history of allergies should be closely monitored.
• Secondary Cancers: There may be an increased risk of developing secondary cancers as a result of radiation exposure.
• Fatigue: Fatigue is a common side effect of Zevalin treatment.
• Liver Enzyme Changes: Zevalin may cause an increase in liver enzymes.
• Pregnancy and Fertility: Zevalin can be harmful to a developing fetus, and precautions must be taken to avoid pregnancy during and after treatment. Fertility may also be affected.

It’s important to note that the decision to use Zevalin is carefully made by healthcare providers after considering the potential benefits and risks for each individual patient. Patients receiving Zevalin are closely monitored for side effects, and healthcare teams take steps to manage and mitigate these risks.

Before starting Zevalin or any treatment, patients should have a thorough discussion with their healthcare provider, addressing any concerns and understanding the potential benefits and risks based on their specific medical history and condition. This information is a general overview, and individual experiences may vary. Always consult with healthcare professionals for personalized advice and guidance.

Why is this medication prescribed?

Zevalin is a prescription medication used in the treatment of certain types of non-Hodgkin’s lymphoma, specifically follicular B-cell lymphoma and transformed B-cell lymphoma. It is generally prescribed when other treatments have not been successful.

Zevalin is a type of radioimmunotherapy. It combines a monoclonal antibody called rituximab with a radioactive substance called yttrium-90. Rituximab targets and attaches to specific proteins on the surface of B-cells, including cancerous B-cells. The radioactive yttrium-90 then delivers radiation directly to the cancerous cells, helping to destroy them.

How should this medicine be used?

Here is a general overview of how Zevalin is used:

• Pre-Treatment Evaluation: Before starting Zevalin treatment, your healthcare provider will conduct various tests to evaluate your overall health and the extent of the lymphoma.
• Rituximab Infusion: The treatment usually begins with an infusion of rituximab. This is done to help target the cancer cells and enhance the effectiveness of the radioactive component.
• Imaging: Imaging tests, such as a PET scan, may be performed to determine the distribution of the cancer cells in your body.
• Zevalin Infusion: A few days after the rituximab infusion, you will receive the Zevalin infusion. This contains the radioactive yttrium-90. The radioactive substance is designed to target and destroy the cancerous B-cells.
• Post-Treatment Monitoring: After the treatment, your healthcare team will monitor you for potential side effects and assess the treatment’s effectiveness through follow-up tests and imaging studies.

It’s important to note that Zevalin is typically administered in a specialized healthcare setting by healthcare professionals experienced in the use of radioactive materials. The specific details of the treatment, including the dosage and schedule, will be determined by your oncologist based on your individual health condition and the type and stage of your lymphoma.

As with any medical treatment, it’s crucial to discuss the potential benefits and risks of Zevalin with your healthcare provider, including possible side effects and any pre-existing conditions that may affect its use in your case. Always follow your healthcare provider’s instructions and attend scheduled follow-up appointments for proper monitoring.

Other uses for this medicine

Zevalin is primarily used for the treatment of certain types of non-Hodgkin’s lymphoma, specifically follicular B-cell lymphoma and transformed B-cell lymphoma. As of last knowledge update, Zevalin is not approved for other uses. It’s important to note that medical information is subject to change, and new uses for medications may have been approved since then. Therefore, it’s crucial to consult with your healthcare provider for the most up-to-date and accurate information.

What special precautions should I follow?

Regarding special precautions, Zevalin is associated with some unique considerations due to its radioactive component. Here are some general precautions and considerations:

• Radiation Safety: Zevalin contains a radioactive substance (yttrium-90). Healthcare providers who administer Zevalin follow strict safety protocols to minimize radiation exposure. Patients are also advised to follow guidelines to limit radiation exposure to others.
• Pregnancy and Breastfeeding: Zevalin can be harmful to a developing fetus. If you are pregnant, planning to become pregnant, or breastfeeding, it’s important to inform your healthcare provider. They will carefully assess the potential risks and benefits and may recommend delaying treatment or alternative options.
• Hematologic Monitoring: Zevalin may affect blood cell counts, including white blood cells, red blood cells, and platelets. Regular blood tests will be performed to monitor these levels. Your healthcare provider will assess whether the benefits of treatment outweigh the risks, especially if you have pre-existing blood disorders.
• Infections: Zevalin can suppress the immune system, increasing the risk of infections. It’s important to promptly report any signs of infection, such as fever or persistent cough, to your healthcare provider.
• Allergic Reactions: Some patients may experience allergic reactions to rituximab, which is part of the Zevalin treatment. Inform your healthcare provider if you have a history of allergies or reactions to similar medications.
• Pre-existing Medical Conditions: Inform your healthcare provider about any pre-existing medical conditions, including heart, lung, or liver conditions, as they may impact the suitability of Zevalin treatment.

Always follow your healthcare provider’s instructions and attend all scheduled appointments for monitoring and follow-up care. The information provided here is a general overview, and individual considerations may vary. Your healthcare team will provide personalized guidance based on your specific medical history and condition.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Zevalin. However, it’s essential to maintain a healthy and balanced diet to support overall well-being. Always follow any dietary advice provided by your healthcare team.

What should I do if I forget a dose?

Zevalin is typically administered in a healthcare setting, and the treatment schedule is carefully planned. If you miss a scheduled appointment for a dose of Zevalin, it’s crucial to contact your healthcare provider immediately. They will provide guidance on the next steps and whether any adjustments to the treatment plan are necessary.

What side effects can this medication cause?

Zevalin, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. Additionally, the benefits of Zevalin treatment are typically weighed against the potential risks. Common side effects, as of last update, include:

• Infusion-related Reactions: Patients may experience reactions during or shortly after the infusion, including fever, chills, nausea, vomiting, and headache. These reactions are usually mild to moderate.
• Hematologic Effects: Zevalin can affect blood cell counts. This may lead to a decrease in white blood cells, red blood cells, and platelets. This can result in an increased risk of infection, anemia, and bleeding.
• Infections: Zevalin can suppress the immune system, making patients more susceptible to infections. Serious infections can occur.
• Fatigue: Fatigue is a common side effect of Zevalin treatment.
• Nausea and Vomiting: Some patients may experience nausea and vomiting.
• Fever: Fever is a common side effect and may be associated with other symptoms of infection.
• Pain: Patients may experience pain, including abdominal pain and bone pain.
• Rash and Skin Reactions: Skin reactions, including rash, have been reported.
• Cough and Respiratory Symptoms: Respiratory symptoms, including cough, have been reported.
• Elevated Liver Enzymes: Zevalin may cause an increase in liver enzymes.
• Allergic Reactions: Serious allergic reactions to Zevalin, including anaphylaxis, have been reported. It’s important to inform your healthcare provider about any history of allergies.
• Secondary Cancers: There may be an increased risk of developing secondary cancers as a result of radiation exposure.

It’s crucial to report any side effects or symptoms to your healthcare provider promptly. Your healthcare team will monitor you closely during and after treatment to manage and address any side effects that may occur. Additionally, before starting Zevalin treatment, your healthcare provider will discuss the potential risks and benefits with you.

This is not an exhaustive list of side effects, and individual experiences may vary. Always consult with your healthcare provider for personalized information based on your health condition and treatment plan.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zevalin:

Storage:

• Healthcare Setting: Zevalin is typically administered in a healthcare setting by trained professionals. The medication is not intended for self-administration.
• Radiation Safety: Zevalin contains a radioactive substance. Storage and handling are strictly regulated to minimize radiation exposure. Healthcare providers follow specific protocols for the safe storage and administration of Zevalin.

Disposal:

• Radiation Safety and Disposal: Zevalin is a radioactive material, and its disposal is subject to strict regulations. Disposal is typically handled by healthcare facilities with expertise in handling radioactive waste.
• Return Unused Medication: Unused portions of Zevalin are typically returned to the healthcare facility for proper disposal.

In case of emergency/overdose

• Emergency Medical Assistance: In case of an emergency or suspected overdose, seek immediate medical attention. Call emergency services or go to the nearest emergency room.
• Radiation Exposure: Overdose of Zevalin can result in increased radiation exposure. Emergency measures will be taken to minimize radiation exposure to healthcare providers and others.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Always follow your healthcare provider’s instructions regarding the use, handling, and disposal of Zevalin.
• Patient Education: Patients should be informed about radiation safety measures and guidelines to minimize radiation exposure to family members and others.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as Zevalin can have implications for fetal development and breastfeeding.
• Monitoring and Follow-Up: Regular monitoring and follow-up appointments are essential during and after Zevalin treatment. Report any side effects or concerns to your healthcare provider promptly.
• Medical History: Provide a complete medical history to your healthcare provider, including information about allergies, pre-existing medical conditions, and medications you are currently taking.
• Radiation Safety Precautions: Follow any radiation safety precautions and guidelines provided by your healthcare team.

It’s important to note that the information provided here is general, and specific guidelines may vary based on individual circumstances and healthcare provider recommendations. Zevalin is a specialized medication with unique considerations, and your healthcare team will provide personalized guidance based on your health condition and treatment plan.