Why is this medication prescribed?

Xpovio (selinexor) is prescribed for the treatment of multiple myeloma. Multiple myeloma is a type of cancer that affects plasma cells, a type of white blood cell found in the bone marrow. Plasma cells play a crucial role in the immune system by producing antibodies to help the body fight infections.

Xpovio is specifically indicated for the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least four prior therapies and whose disease is resistant to several other forms of treatment, including proteasome inhibitors, immunomodulatory agents, and an anti-CD38 monoclonal antibody.

How should this medicine be used?

Here are some general guidelines for the use of Xpovio:

• Dosage: The dosage of Xpovio can vary. Your doctor will determine the appropriate dosage based on your individual circumstances.
• Administration: Xpovio is usually taken orally with or without food. It is important to swallow the tablets whole with water and not crush or chew them.
• Schedule: The medication is often administered on a specific schedule, and it’s crucial to follow the prescribed timing and frequency. Missing doses or altering the schedule without consulting your healthcare provider can affect the effectiveness of the treatment.
• Follow-up: Regular follow-up appointments with your healthcare provider are essential. They will monitor your response to the medication, manage any side effects, and adjust the treatment plan if necessary.
• Precautions: Inform your doctor about any other medications, supplements, or health conditions you have before starting Xpovio. Certain medications or conditions may interact with Xpovio or require adjustments in dosage.

It’s crucial to keep in mind that this information is general, and the specific details for your case may differ. Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about your medication. If there have been developments or changes in medical guidelines or approvals, you should check with a healthcare professional or reliable medical sources for the latest information on Xpovio.

Other uses for this medicine

Xpovio (selinexor) was primarily indicated for the treatment of multiple myeloma. However, the information provided here is based on my last update, and new uses or precautions may have been approved or discovered since then. Always consult with a healthcare professional or refer to the most recent prescribing information for the latest details on Xpovio.

What special precautions should I follow?

Regarding special precautions for Xpovio, it’s important to note that medications can have specific guidelines and considerations that are crucial for patient safety. Here are some general precautions that were relevant as of my last update:

• Blood Counts: Xpovio may affect blood cell counts, including white blood cells, red blood cells, and platelets. Regular blood tests may be required to monitor these counts during treatment.
• Gastrointestinal Effects: Xpovio can cause nausea, vomiting, and diarrhea. Adequate hydration and anti-nausea medications may be recommended to manage these side effects.
• Renal and Hepatic Function: Xpovio may impact kidney and liver function. Regular monitoring of renal and hepatic function may be necessary during treatment.
• Increased Bleeding Risk: Xpovio may increase the risk of bleeding. Caution is advised in patients with a history of bleeding disorders or those taking medications that may increase the risk of bleeding.
• Neurological Effects: Xpovio can cause neurological side effects, including dizziness and changes in mental alertness. Patients should exercise caution when driving or operating machinery.
• Pregnancy and Contraception: Xpovio may cause harm to a developing fetus. Adequate contraception is advised during treatment, and it is not recommended for use during pregnancy.
• Hematologic Toxicities: Xpovio may cause hematologic toxicities, including thrombocytopenia and neutropenia. Monitoring blood counts is important, and dose adjustments may be necessary based on the results.
• Infections: Patients taking Xpovio may be at an increased risk of infections. Close monitoring for signs of infection and appropriate management are essential.

It’s important to emphasize that the information provided here is general, and individual patient circumstances may vary. Patients should always follow the specific instructions and advice of their healthcare providers. If there have been updates or changes in medical guidelines or approvals, it is recommended to consult with a healthcare professional or refer to the latest medical literature for the most up-to-date information on Xpovio.

What special dietary instructions should I follow?

There were no specific dietary instructions provided for Xpovio. However, dietary considerations can vary based on individual patient needs and overall health. It is advisable to discuss any dietary concerns or restrictions with your healthcare provider.

What should I do if I forget a dose?

If you forget to take a dose of Xpovio, it’s important to follow the specific instructions provided by your healthcare provider. In general, the steps you should take may include:

• Contact Your Healthcare Provider: Inform your healthcare provider about the missed dose as soon as possible.
• Follow Instructions: Your healthcare provider will provide guidance on whether to take the missed dose, skip it, or make any adjustments to your dosing schedule. Do not take extra doses to make up for a missed one without consulting your healthcare provider.

What side effects can this medication cause?

Xpovio (selinexor) is associated with various side effects, and the severity and occurrence of these side effects can vary from person to person. Always consult with a healthcare professional or refer to the most recent prescribing information for the latest details on Xpovio.

Common side effects of Xpovio include:

• Nausea: Xpovio can cause nausea. Your healthcare provider may prescribe anti-nausea medications to help manage this side effect.
• Vomiting: Some individuals may experience vomiting as a side effect of Xpovio.
• Fatigue: Tiredness or fatigue is a common side effect reported by individuals taking Xpovio.
• Decreased Appetite: Some people may experience a reduced appetite while taking Xpovio.
• Diarrhea: Xpovio can cause diarrhea. Adequate hydration and dietary adjustments may be recommended to manage this side effect.
• Thrombocytopenia: A decrease in platelet levels (thrombocytopenia) is a potential side effect of Xpovio. This can increase the risk of bleeding.
• Anemia: Xpovio may lead to a decrease in red blood cell count, resulting in anemia.
• Neutropenia: A reduction in neutrophils (a type of white blood cell) may occur, increasing the risk of infections.
• Hyponatremia: Xpovio may cause low levels of sodium in the blood (hyponatremia), which can lead to symptoms such as confusion, seizures, and nausea.
• Weight Loss: Some individuals may experience weight loss while taking Xpovio.
• Peripheral Neuropathy: Xpovio may cause peripheral neuropathy, leading to symptoms such as tingling, numbness, and pain in the extremities.
• Insomnia: Difficulty sleeping or insomnia may occur as a side effect of Xpovio.

It’s crucial to report any side effects or concerns to your healthcare provider promptly. Additionally, if you experience severe or persistent side effects, it’s important to seek medical attention.

This list is not exhaustive, and other side effects may occur. Individual responses to medications can vary, and your healthcare provider will monitor you for potential side effects and adjust your treatment plan as needed. Always follow the guidance provided by your healthcare team for the safest and most effective use of Xpovio.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage:
  • Store Xpovio at room temperature, away from direct sunlight and moisture.
  • Keep it in its original packaging or container to protect it from light.
  • Follow any specific storage instructions provided by your pharmacist or healthcare provider.
• Disposal:
  • Dispose of unused or expired medications properly according to local regulations.
  • Check with your pharmacist or healthcare provider for guidance on the proper disposal of Xpovio.
  • Do not flush medications down the toilet unless instructed to do so.

In case of emergency/overdose

In case of an emergency or suspected overdose, contact your local poison control center (1-800-222-1222 in the United States) or seek emergency medical attention immediately. Symptoms of an overdose may vary, and it’s essential to get prompt medical assistance.

What other information should I know?

• Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. They will monitor your response to treatment, assess any side effects, and make necessary adjustments to your treatment plan.
• Lab Monitoring: Your healthcare provider may order regular blood tests to monitor your blood cell counts and overall health during Xpovio treatment.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Xpovio.
• Pregnancy and Contraception: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. Xpovio may harm a developing fetus, and effective contraception is crucial during treatment.
• Driving and Machinery: Be cautious when driving or operating machinery, as Xpovio may cause dizziness and changes in mental alertness.
• Inform Healthcare Providers: Before any surgical procedures or dental work, inform your healthcare providers that you are taking Xpovio.
• Patient Education: Understand the potential side effects of Xpovio and how to manage them. Report any unusual or severe side effects to your healthcare provider.

Always follow the specific instructions provided by your healthcare provider and the prescribing information for Xpovio. If there have been updates or changes in medical guidelines, consult with your healthcare provider or refer to the latest medical literature for the most up-to-date information.