Why is this medication prescribed?

Xadago (safinamide) is a medication used in the treatment of Parkinson’s disease. It is primarily prescribed as an adjunct to levodopa/carbidopa in patients with Parkinson’s disease who experience “off” episodes. “Off” episodes are periods when the effectiveness of levodopa wears off, leading to a return of Parkinson’s symptoms.

Safinamide, the active ingredient in Xadago, is a monoamine oxidase-B (MAO-B) inhibitor. It works by increasing the levels of dopamine in the brain, helping to improve motor symptoms associated with Parkinson’s disease.

How should this medicine be used?

The recommended dosage and usage instructions for Xadago (safinamide) were as follows:

• Dosage: The usual starting dose of Xadago is 50 mg once daily. The dosage may be increased to 100 mg once daily based on the individual patient’s needs and tolerance.
• Administration: Xadago is typically taken orally with or without food. It’s important to follow the healthcare provider’s instructions regarding the timing of Xadago administration in relation to other medications.
• Interaction with Other Medications: Xadago may interact with other medications, including those affecting serotonin levels. Therefore, it’s crucial to inform the healthcare provider about all medications, supplements, and herbal products being taken.
• Special Considerations: Individual responses to medication can vary, and the prescribing healthcare provider will monitor the patient’s response to determine the appropriate dose.

It’s important to note that these are general guidelines, and individual patient instructions may vary. Patients should always follow the specific guidance provided by their healthcare provider and carefully read the medication guide that comes with the prescription.

Other uses for this medicine

Xadago is specifically indicated for Parkinson’s disease, and its use for other conditions is not approved. However, medical information can change, and new uses for medications may have been identified since then. Always consult with a healthcare professional or check the latest prescribing information for the most up-to-date and accurate details.

What special precautions should I follow?

Regarding special precautions for Xadago, it’s essential to follow your healthcare provider’s instructions and adhere to the prescribed dosage. Here are some general precautions associated with Xadago:

• Interaction with Other Medications: Xadago can interact with other medications, especially those that affect serotonin levels. Inform your healthcare provider about all the medications, supplements, and herbal products you are taking.
• Hypertension (High Blood Pressure): Xadago may increase blood pressure. Regular monitoring of blood pressure is recommended, especially at the beginning of treatment.
• Falling Asleep During Activities: Some patients taking Xadago have reported falling asleep during daily activities. If you experience sudden sleepiness or episodes of falling asleep without warning, inform your healthcare provider.
• Impulse Control Disorders: Some individuals may develop impulsive behaviors or compulsive disorders. Report any changes in behavior to your healthcare provider.
• Pregnancy and Breastfeeding: The safety of Xadago during pregnancy and breastfeeding is not well-established. Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Liver Function: Xadago is metabolized in the liver. Regular liver function tests may be recommended, especially for individuals with pre-existing liver conditions.
• Allergies: Inform your healthcare provider of any known allergies to medications, especially if you have had a reaction to safinamide or any other ingredients in Xadago.

It’s crucial to have open and honest communication with your healthcare provider about your medical history, current medications, and any concerns or side effects you may experience while taking Xadago. Always follow your healthcare provider’s recommendations and attend regular follow-up appointments. If you have specific questions or concerns about Xadago, consult your healthcare provider for personalized advice.

What special dietary instructions should I follow?

As of last knowledge update, there were no specific dietary restrictions mentioned for Xadago. However, dietary considerations can vary based on individual health conditions and the overall treatment plan. It’s advisable to consult your healthcare provider or pharmacist for personalized advice regarding your diet while taking Xadago.

What should I do if I forget a dose?

If you forget to take a dose of Xadago, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have concerns or questions about missed doses or any aspect of your medication regimen, contact your healthcare provider for guidance.

What side effects can this medication cause?

Xadago (safinamide) is a medication used in the treatment of Parkinson’s disease. Like any medication, Xadago can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed. Common side effects and less common but potentially serious side effects associated with Xadago include:

Common Side Effects:

• Uncontrolled movements (dyskinesia): Xadago may cause or worsen uncontrolled, involuntary movements.
• Falls: Some individuals taking Xadago may be at an increased risk of falling.
• Nausea: Nausea is a common side effect.
• Insomnia: Difficulty sleeping or insomnia may occur.
• Elevated blood pressure: Xadago can cause an increase in blood pressure, and regular monitoring may be necessary.

Less Common but Potentially Serious Side Effects:

• Hypertension (high blood pressure): In some cases, Xadago can lead to increased blood pressure.
• Serotonin syndrome: This is a potentially life-threatening condition that can occur when there is too much serotonin in the body. Symptoms may include confusion, hallucinations, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. It’s essential to seek medical attention if you experience these symptoms.
• Hallucinations and psychotic-like behavior: Xadago may increase the risk of hallucinations and other psychotic-like behaviors.
• Impulse control/compulsive behaviors: Some individuals may develop impulsive behaviors or compulsive disorders.
• Dyskinesia: Xadago may cause or worsen uncontrolled movements.
• Orthostatic hypotension: A sudden drop in blood pressure upon standing, leading to dizziness or fainting.

It’s crucial to report any unusual or severe side effects to your healthcare provider promptly. Individual responses to medications can vary, and your healthcare provider will be able to assess your specific situation and make adjustments to your treatment plan if necessary. Always consult with your healthcare provider or pharmacist and refer to the most current prescribing information for Xadago for the latest information on side effects and safety considerations.

What should I know about storage and disposal of this medication?

Storage and Disposal of Xadago:

• Storage: Follow the storage instructions provided by your healthcare provider or pharmacist. Typically, medications like Xadago should be stored at room temperature away from light and moisture. Avoid storing it in the bathroom, as moisture can affect the medication.
• Keep Out of Reach of Children: Store Xadago in a location that is inaccessible to children and pets to prevent accidental ingestion.
• Disposal: Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details on how to safely dispose of your product.

In case of emergency/overdose

If you suspect an overdose or experience severe side effects, seek emergency medical attention immediately. Symptoms of an overdose may include:

• Severe dizziness or fainting
• Uncontrolled movements (dyskinesia)
• Hallucinations or psychotic-like behavior
• Extreme changes in blood pressure
• Seizures

Contact your local poison control center or emergency room for advice if you suspect an overdose. Be sure to provide as much information as possible about the medication and the amount ingested.

What other information should I know?

• Follow Prescribed Dosage: Take Xadago exactly as prescribed by your healthcare provider. Do not change your dose without consulting your healthcare provider.
• Regular Follow-Up: Attend regular follow-up appointments with your healthcare provider to monitor the effectiveness of the medication and address any concerns or side effects.
• Inform Healthcare Provider: Keep your healthcare provider informed about all medications, supplements, and herbal products you are taking, as well as any changes in your health status.
• Allergies: Inform your healthcare provider of any known allergies to medications, especially if you have had a reaction to safinamide or any other ingredients in Xadago.
• Driving and Operating Machinery: Be cautious when driving or operating machinery, as Xadago may cause dizziness or sudden sleepiness.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Xadago during pregnancy and breastfeeding should be discussed with your healthcare provider.
• Interaction with Other Medications: Be aware of potential drug interactions. Inform your healthcare provider about all medications you are taking.

Always consult with your healthcare provider or pharmacist for specific guidance tailored to your individual circumstances. This information is not exhaustive, and the most accurate and current details can be found in the prescribing information for Xadago or through direct consultation with your healthcare provider.