Why is this medication prescribed?

Vyepti (eptinezumab) is a prescription medication used for the preventive treatment of migraine in adults. Migraine is a neurological disorder characterized by recurrent moderate to severe headaches often accompanied by nausea, vomiting, and sensitivity to light and sound.

Eptinezumab, the active ingredient in Vyepti, is a monoclonal antibody that targets and inhibits calcitonin gene-related peptide (CGRP), a molecule believed to play a key role in migraine attacks.

How should this medicine be used?

Here are general guidelines on how Vyepti is typically used:

• Dosage: The standard dosage of Vyepti is 100 mg, and it is administered every 3 months. Your healthcare provider will determine the appropriate dosage and schedule based on your specific situation.
• Administration: Vyepti is administered as an intravenous infusion, which means it is delivered directly into your bloodstream through a vein. The infusion is typically done over about 30 minutes.
• Clinical Setting: Vyepti infusions are usually given in a clinical setting, such as a doctor’s office, infusion center, or hospital. A healthcare professional will administer the infusion, and you will be monitored during and after the infusion to ensure there are no adverse reactions.
• Frequency: The recommended frequency of Vyepti infusions is once every 3 months. It’s important to attend all scheduled appointments as prescribed by your healthcare provider.
• Preparation: Before starting Vyepti, inform your healthcare provider about all medications you are currently taking, including prescription and over-the-counter drugs, as well as any supplements. Your healthcare provider will consider this information to ensure there are no potential interactions.
• Side Effects: While receiving the infusion, you may experience certain side effects. Common side effects of Vyepti include mild reactions at the infusion site, such as redness or discomfort. Serious allergic reactions are rare but possible. If you experience any unexpected side effects or have concerns, notify your healthcare provider immediately.

Always follow your healthcare provider’s recommendations and attend all scheduled appointments. If you have any questions or concerns about the use of Vyepti, discuss them with your healthcare provider. This information is general, and individual circumstances may vary, so it’s important to consult with your healthcare provider for personalized guidance.

Other uses for this medicine

Vyepti (eptinezumab) is specifically approved for the preventive treatment of migraine in adults and is not indicated for other uses. It’s important to note that new information or indications may have emerged since then, so it’s advisable to consult the most recent prescribing information or your healthcare provider for the latest updates.

What special precautions should I follow?

Regarding special precautions for Vyepti, it’s crucial to follow your healthcare provider’s guidance and discuss any specific concerns you may have. Here are some general precautions and considerations:

• Allergies: Inform your healthcare provider of any known allergies or hypersensitivity reactions to eptinezumab or any of the components of Vyepti.
• Medication Interactions: Provide a complete list of all medications, including prescription and over-the-counter drugs, as well as any supplements or herbal products you are taking. Certain medications may interact with Vyepti, and your healthcare provider will consider this when determining the appropriate treatment plan.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The safety of Vyepti during pregnancy and breastfeeding has not been established, and the potential risks and benefits should be carefully considered.
• Immunizations: Inform your healthcare provider of any upcoming vaccinations or immunizations. Live vaccines should generally be avoided during treatment with immunosuppressive medications like Vyepti.
• Infections: Since Vyepti may affect the immune system, there may be an increased risk of infections. If you develop signs of infection, such as fever or persistent cough, notify your healthcare provider.
• Monitoring: Your healthcare provider may monitor you for any adverse reactions during and after the infusion. Be sure to report any side effects or unusual symptoms promptly.
• Hypersensitivity Reactions: Although serious allergic reactions to Vyepti are rare, it’s essential to be aware of signs of hypersensitivity, such as rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you experience any of these symptoms.

Remember that the information provided here is general, and individual circumstances may vary. Always follow your healthcare provider’s instructions and consult with them for personalized advice based on your specific medical condition and history.

What special dietary instructions should I follow?

As of last update, there were no specific dietary instructions associated with Vyepti. However, it’s always a good idea to discuss your dietary habits and any concerns with your healthcare provider. They can provide personalized guidance based on your overall health and medical condition.

What should I do if I forget a dose?

Vyepti is typically administered as an intravenous infusion in a healthcare setting every 3 months. If you miss a scheduled infusion, it’s important to contact your healthcare provider as soon as possible to reschedule. Do not attempt to administer the medication on your own.

What side effects can this medication cause?

Vyepti (eptinezumab) may cause side effects, and it’s important to be aware of them. Remember that individual responses can vary, and not everyone will experience the same side effects. Common side effects and potential adverse reactions associated with Vyepti include:

• Hypersensitivity Reactions: Serious allergic reactions are rare but can occur. Signs of a hypersensitivity reaction may include rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you experience any of these symptoms.
• Infusion Reactions: During or after the infusion, you may experience reactions such as flushing, increased blood pressure, chest pain, or changes in heart rate. These reactions are generally mild to moderate in severity.
• Infections: Since Vyepti may affect the immune system, there is a potential increased risk of infections. If you develop signs of infection, such as fever or persistent cough, inform your healthcare provider.
• Site Reactions: Mild reactions at the infusion site, such as redness or discomfort, are common.
• Constipation: Constipation has been reported as a side effect in some individuals.
• Muscle Spasms: Some people may experience muscle spasms as a side effect of Vyepti.

It’s essential to report any unusual or severe side effects to your healthcare provider promptly. Your healthcare provider will weigh the potential benefits of Vyepti in managing migraines against the risks of side effects.

If you have concerns about the side effects of Vyepti or experience any unexpected symptoms, contact your healthcare provider for guidance. Always follow your healthcare provider’s instructions and attend all scheduled appointments for monitoring and evaluation during and after the infusion.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Vyepti is typically administered in a healthcare setting, and the storage of the medication is managed by healthcare professionals. If you are given any specific instructions for storage at home (such as if you have a supply for use between appointments), follow those instructions closely.
• Disposal: Unused or expired medications, including Vyepti, should be properly disposed of according to local regulations. Do not flush medications down the toilet unless instructed to do so. Check with your healthcare provider or local pharmacy for guidance on how to dispose of Vyepti properly.

In case of emergency/overdose

In case of emergency or overdose, it is crucial to seek immediate medical attention. Contact your local poison control center or emergency room. Be prepared to provide information about the medication, dosage, and any symptoms experienced. If possible, have the Vyepti packaging or prescription information available.

What other information should I know?

• Follow-up Appointments: Attend all scheduled appointments for Vyepti infusions. Regular follow-up visits are essential for monitoring your response to the medication and assessing any potential side effects.
• Informing Healthcare Providers: Make sure to inform all healthcare providers involved in your care, including dentists and specialists, that you are receiving Vyepti. This is important for comprehensive and coordinated healthcare.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The safety of Vyepti in pregnancy and breastfeeding has not been well established.
• Medical Alert Bracelet/ID: Depending on your medical history and the advice of your healthcare provider, you may consider wearing a medical alert bracelet or carrying identification indicating that you are receiving Vyepti in case of emergencies.

Always consult with your healthcare provider or pharmacist for the most accurate and up-to-date information related to the storage, disposal, and other considerations for Vyepti based on your specific situation.