Why is this medication prescribed?

Adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis; a genetic disorder in which aberrant proteins accumulate and deposit in tissues, causing nerve damage are treated with vitrinir. Vutrisiran belongs to the group of drugs known as small interfering RNAs (siRNAs). It reduces nerve damage by lowering the quantity of aberrant proteins and the quantity of abnormal proteins deposited in the body’s tissues.

How should this medicine be used?

The injection of vutrisiran is administered subcutaneously, or beneath the skin, as a solution (liquid). Every three months, a doctor or nurse will typically administer it in a clinic.

Request a copy of the patient’s manufacturer’s information from your pharmacist or physician.

Other uses for this medicine

Ask your doctor or pharmacist for more information if you think this medicine could be recommended for something else.

What special precautions should I follow?

Here are some general precautions:

• If you have an allergy to vutrisiran, any other drug, or any of the ingredients in vutrisiran injection, let your doctor and pharmacist know. Get an ingredient list from your pharmacist.
• When taking vutrisiran, let your doctor and pharmacist know about all the vitamins, nutritional supplements, herbal items, and prescription and over-the-counter medications you currently take or intend to use. Your doctor might need to adjust your medicine dosage or closely watch you for any negative effects.
• Inform your physician if you currently have low vitamin A levels, liver illness, or kidney disease.
• Vitamin A levels in your body may drop as a result of vitrimisiran. It is possible that your doctor would advise you to take a vitamin A supplement in addition to the vutrisiran injection.
• Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. While the effects of vutrisiran on the fetus are unknown, low vitamin A levels can impact development, so you should talk to your doctor about the risks and benefits of becoming pregnant while taking vutrisiran. Contact your physician if you become pregnant while having an injection of vutrisiran.

Always follow the specific instructions provided by your healthcare provider and refer to the most recent and relevant prescribing information for vutrisiran. If you have questions or concerns about the medication, your healthcare provider is the best source of information for personalized guidance based on your health status.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with vutrisiran injection. However, maintaining a healthy and balanced diet is important for overall well-being.

What should I do if I forget a dose?

• If you forget to take a dose of any medication, including vutrisiran, it is important to contact your healthcare provider for guidance.
• Do not double the next dose to make up for a missed one without consulting your healthcare provider.

What side effects can this medication cause?

Vutrisiran injection, like any medication, may cause side effects. It’s important to note that not everyone will experience these side effects, and the severity and frequency of side effects can vary among individuals. Common side effects of vutrisiran injection, may include:

• Joint pain
• Shortness of breath
• Bruising, pain, swelling, redness, itching and warmth at the site of injection

Some side effects can be serious. If you experience any of these symptoms while receiving vutrisiran, call your doctor immediately:

• Difficulty seeing at night or in low light
• Irregular heartbeatI

Please note that the information provided here is general and may not reflect the most current data on vutrisiran. Always rely on the information provided by healthcare professionals and official prescribing documents for the most accurate and personalized guidance.

What should I know about storage and disposal of this medication?

Storage and Disposal of vutrisiran injection:

• Storage:
  • Vutrisiran injection is typically administered in a healthcare setting, and the storage is the responsibility of the medical facility.
  • If you are provided with any unused vials or materials at home, store them as directed by your healthcare provider or pharmacist.
• Disposal:
  • Proper disposal of medical waste is crucial. Do not dispose of Visudyne vials, used needles, or any medical waste in regular household trash.
  • Follow local regulations and guidelines for the disposal of medical waste. Your healthcare provider or pharmacist can provide specific instructions.

In case of emergency/overdose

• In case of an emergency or suspected overdose, seek immediate medical attention.
• Contact your local poison control center or emergency room for guidance.

What other information should I know?

• Inform your healthcare provider about all medications you are taking, including prescription, over-the-counter, and herbal supplements.
• Attend regular follow-up appointments with your healthcare provider to monitor your response to the medication and address any concerns.
• Be aware of any potential side effects and report them to your healthcare provider promptly.
• If you miss a dose, contact your healthcare provider for guidance on what to do.

Remember that the information provided here is general in nature and may not be specific to vutrisiran. Always refer to the prescribing information or consult with a healthcare professional for the most accurate and personalized guidance based on your specific situation.