WARNING

While Vesanoid (tretinoin) is an effective medication for the treatment of acute promyelocytic leukemia (APL), it does come with certain risks and potential side effects. It’s important to balance these risks against the benefits of the medication. Here are some key risks associated with taking Vesanoid:

• Retinoic Acid Syndrome (RAS): This is a potentially serious side effect characterized by symptoms such as fever, difficulty breathing, weight gain, and swelling. It requires prompt medical attention.
• Dryness and Skin Changes: Vesanoid can cause dryness of the skin and mucous membranes, potentially leading to skin irritation and discomfort.
• Increased Sensitivity to Sunlight: Tretinoin can make the skin more sensitive to sunlight, increasing the risk of sunburn. Sun protection measures are recommended.
• Changes in Blood Cell Counts: Vesanoid can cause changes in white blood cell, red blood cell, and platelet counts. Regular blood tests are needed to monitor these changes.
• Liver Function: Vesanoid may affect liver function, leading to an increase in liver enzymes. Regular monitoring is typically required.
• Pseudotumor Cerebri: There have been reports of increased intracranial pressure (pseudotumor cerebri) associated with Vesanoid.
• Headache and Other Side Effects: Headaches are a common side effect, and other side effects may include nausea, vomiting, and musculoskeletal pain.
• Birth Defects: Vesanoid can cause severe birth defects if taken during pregnancy. Effective contraception is crucial during treatment and for a period after discontinuation.

It’s important for individuals taking Vesanoid to communicate openly with their healthcare provider, attend regular follow-up appointments, and report any unusual or severe side effects promptly. The decision to use Vesanoid is typically made by weighing the potential risks against the benefits of treating acute promyelocytic leukemia. Patients should follow their healthcare provider’s instructions closely and seek medical attention for any concerns or emergencies.

Why is this medication prescribed?

Vesanoid is a brand name for the medication tretinoin, which is a form of vitamin A. It is primarily prescribed for the treatment of acute promyelocytic leukemia (APL), a type of cancer affecting the bone marrow and blood. Tretinoin works by promoting the maturation of abnormal white blood cells in the bone marrow, helping to restore normal blood cell production.

How should this medicine be used?

Here are general guidelines for how Vesanoid is typically used, but it’s crucial to follow your doctor’s specific instructions:

• Dosage: The dosage of Vesanoid can vary based on individual factors and the specific characteristics of the leukemia. Your doctor will determine the appropriate dosage for you.
• Administration: Vesanoid is usually taken orally as capsules. It’s important to take the medication exactly as prescribed by your doctor. This often involves taking the capsules with a full glass of water, and they are typically taken once or twice a day.
• Consistency: Try to take Vesanoid at the same time(s) each day to maintain a consistent level of the medication in your bloodstream.
• Food Interactions: Vesanoid can be taken with or without food. However, it’s important to follow your doctor’s instructions regarding whether to take it with meals or on an empty stomach.
• Duration: Treatment with Vesanoid is typically a part of a comprehensive leukemia treatment plan. The duration of treatment and the specific regimen will be determined by your healthcare provider based on your response to the medication and the overall treatment plan.
• Monitoring: Regular monitoring, including blood tests and other assessments, will likely be conducted by your healthcare team to evaluate the effectiveness of the treatment and manage any potential side effects.

It’s crucial to communicate openly with your healthcare provider about any concerns, side effects, or questions you may have during your treatment with Vesanoid. Adhering to your doctor’s instructions and attending all scheduled appointments are important aspects of managing leukemia and its treatment.

Other uses for this medicine

While Vesanoid (tretinoin) is primarily known for its use in the treatment of acute promyelocytic leukemia (APL), it may also be prescribed for certain dermatological conditions. Tretinoin, the active ingredient in Vesanoid, is commonly used topically for the treatment of acne. However, when used for this purpose, it is often in the form of creams or gels rather than oral capsules.

What special precautions should I follow?

As for special precautions when using Vesanoid, it’s essential to follow your doctor’s instructions carefully. Here are some general precautions associated with Vesanoid:

• Pregnancy and Contraception: Vesanoid can cause severe birth defects if taken during pregnancy. It is essential to use effective contraception during treatment, and your doctor may require pregnancy tests before starting and during treatment. Both men and women should use effective contraception for at least one month after stopping treatment.
• Liver Function: Your doctor may monitor your liver function regularly during treatment, as Vesanoid can affect liver enzymes.
• Interactions with Other Medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking. Some drugs may interact with Vesanoid, potentially affecting its effectiveness or increasing the risk of side effects.
• Side Effects: Be aware of potential side effects, including but not limited to headache, fever, dry skin, nausea, and changes in blood cell counts. Report any unusual or severe side effects to your doctor promptly.
• Avoid Vitamin A Supplements: High doses of vitamin A supplements should be avoided while taking Vesanoid, as they can increase the risk of side effects.
• Sun Exposure: Tretinoin can make your skin more sensitive to sunlight. Avoid prolonged sun exposure and use sunscreen when outdoors.
• Special Populations: Use caution in elderly patients, and those with renal or hepatic impairment. Adjustments to the dosage may be necessary based on individual health conditions.
• Breastfeeding: It is not recommended to breastfeed while taking Vesanoid.

Always consult with your healthcare provider regarding any specific precautions or recommendations for your individual case. They will consider your medical history, current medications, and other factors to provide guidance tailored to your needs. Never adjust your dosage or stop taking Vesanoid without consulting your healthcare provider.

What special dietary instructions should I follow?

Vesanoid can be taken with or without food. Follow your doctor’s instructions regarding whether to take it with meals or on an empty stomach.

What should I do if I forget a dose?

• Missed Dose: If you forget to take a dose of Vesanoid, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Double Dosing: Do not take a double dose to make up for a missed one. Taking more than the prescribed amount will not improve your condition and may increase the risk of side effects.
• Inform Your Doctor: If you miss a dose, it’s advisable to inform your doctor. They can provide guidance on how to proceed and whether any adjustments to your treatment plan are necessary.

What side effects can this medication cause?

Vesanoid (tretinoin) can cause various side effects, and the severity and occurrence of these side effects can vary from person to person. It’s important to note that the benefits of using Vesanoid are generally considered to outweigh the potential risks, especially in the treatment of acute promyelocytic leukemia (APL). Here are some common side effects associated with Vesanoid:

• Retinoic Acid Syndrome (RAS): This is a potentially serious side effect that can occur with the use of Vesanoid. Symptoms may include fever, difficulty breathing, weight gain, and swelling. If you experience these symptoms, it’s important to seek medical attention promptly.
• Headache: Headaches are a common side effect of Vesanoid.
• Dry Skin and Mucous Membranes: Tretinoin can cause dryness of the skin and mucous membranes, including the inside of the nose and mouth.
• Nausea and Vomiting: Some individuals may experience nausea and vomiting while taking Vesanoid.
• Fever: Fever is a common side effect, and it can sometimes be a symptom of retinoic acid syndrome.
• Bone Pain: Musculoskeletal pain, including bone pain, has been reported in some patients.
• Increased Liver Enzymes: Vesanoid can affect liver function, leading to an increase in liver enzymes.
• Changes in Blood Cell Counts: Vesanoid can cause changes in white blood cell, red blood cell, and platelet counts. Regular blood tests are usually conducted to monitor these changes.
• Increased Intracranial Pressure: Cases of pseudotumor cerebri (increased pressure inside the skull) have been reported with the use of Vesanoid.
• Allergic Reactions: Allergic reactions, though rare, can occur. Seek medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s important to report any unusual or severe side effects to your healthcare provider promptly. Your doctor will monitor your condition and adjust the treatment plan as needed. Keep in mind that the benefits of Vesanoid in treating acute promyelocytic leukemia are well-established, and the side effects should be weighed against the potential benefits of the medication. Always follow your doctor’s instructions and attend regular follow-up appointments for monitoring.

What should I know about storage and disposal of this medication?

Storage of Vesanoid:

• Temperature: Store Vesanoid at room temperature, away from excessive heat and moisture.
• Container: Keep the medication in its original container to protect it from light.
• Childproofing: Store Vesanoid out of reach of children and pets. The capsules should not be handled by pregnant women.

Disposal of Vesanoid:

• Dispose of Unused Medication: If you have any unused or expired Vesanoid, it’s important to dispose of it properly. Follow your local guidelines or consult with your healthcare provider or pharmacist on the appropriate method for disposal.
• Do Not Flush: Do not flush medications down the toilet unless instructed to do so. This helps prevent environmental contamination.

In case of emergency/overdose

In case of an emergency or overdose, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention. Symptoms of an overdose may include severe headache, vomiting, and visual disturbances.

What other information should I know?

• Regular Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. Regular monitoring, including blood tests, is crucial to evaluate the effectiveness of the treatment and manage any potential side effects.
• Pregnancy and Contraception: If you are pregnant, planning to become pregnant, or breastfeeding, inform your healthcare provider. Effective contraception is crucial during treatment and for a period after discontinuation.
• Communication with Healthcare Provider: Report any new or worsening symptoms, side effects, or concerns to your healthcare provider promptly.
• Avoid Vitamin A Supplements: Avoid taking high doses of vitamin A supplements while on Vesanoid, as this can increase the risk of side effects.
• Sun Protection: Tretinoin can increase sensitivity to sunlight. Use sun protection measures such as sunscreen and protective clothing, and avoid prolonged sun exposure.
• Inform Healthcare Providers: Make sure to inform all healthcare providers involved in your care, including dentists and surgeons, that you are taking Vesanoid.

Always follow your healthcare provider’s instructions and guidelines for the use, storage, and disposal of Vesanoid. If you have specific questions or concerns, consult with your healthcare provider or pharmacist for personalized advice.