Why is this medication prescribed?

Abemaciclib is a prescription medication used in the treatment of certain types of cancer. It belongs to a class of drugs called cyclin-dependent kinase (CDK) inhibitors. CDKs are proteins that regulate the cell cycle, and their overactivity can contribute to the uncontrolled growth of cancer cells.

Abemaciclib is specifically used for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer. It is often prescribed in combination with other hormonal therapies, such as aromatase inhibitors, for postmenopausal women, or fulvestrant for both premenopausal and postmenopausal women.

How should this medicine be used?

Dosage and administration instructions for Abemaciclib can vary based on the specific treatment plan prescribed by the oncologist. It is important to follow the healthcare provider’s recommendations and the instructions on the prescription label. In general, Abemaciclib is taken orally with or without food.

Common guidance for using Abemaciclib may include:

• Dosage: The prescribed dosage can vary, and it’s important to take the exact amount as directed by the healthcare provider.
• Schedule: Abemaciclib is often taken twice daily, approximately 12 hours apart.
• Swallow whole: The tablets should be swallowed whole with a glass of water. They should not be chewed, crushed, or broken.
• Consistent timing: Try to take Abemaciclib at the same times each day to maintain a consistent level of the medication in the body.
• Monitoring: Regular monitoring of blood counts and liver function may be necessary during treatment.
• Follow-up appointments: It’s crucial to attend follow-up appointments with the healthcare provider to monitor the progress of the treatment and address any potential side effects.

It’s important to note that individual patient circumstances can vary, and healthcare providers will tailor the treatment plan based on the specific characteristics of the cancer and the patient’s overall health. Always consult with a healthcare professional for personalized advice and information regarding the use of Abemaciclib or any other medications.

Other uses for this medicine

Abemaciclib is primarily used for the treatment of advanced or metastatic breast cancer. However, ongoing research and clinical trials may explore its potential use in other types of cancers or conditions. It’s important to consult with a healthcare professional or check more recent sources for any updates on additional uses.

What special precautions should I follow?

Regarding special precautions for Abemaciclib, it’s essential to consider the following:

• Pregnancy and breastfeeding: Abemaciclib can cause harm to an unborn baby, so it’s crucial to inform your healthcare provider if you are pregnant or planning to become pregnant. Additionally, breastfeeding is not recommended during Abemaciclib treatment.
• Liver function: Abemaciclib may affect liver function, so individuals with pre-existing liver conditions or elevated liver enzymes may require additional monitoring. Your healthcare provider may perform regular blood tests to assess liver function.
• Blood cell counts: Abemaciclib can cause a decrease in certain blood cell counts, including white blood cells, red blood cells, and platelets. Regular blood tests may be conducted to monitor these levels, and dose adjustments or interruptions may be necessary based on the results.
• Diarrhea: Diarrhea is a common side effect of Abemaciclib. It’s important to notify your healthcare provider if you experience severe or persistent diarrhea, as they may prescribe medications or recommend other measures to manage this side effect.
• Other medications and supplements: Inform your healthcare provider about all the medications, vitamins, and supplements you are taking, as they may interact with Abemaciclib.
• Heart-related issues: Abemaciclib may cause changes in the electrical activity of the heart. Individuals with a history of heart disease or other cardiac issues should discuss these conditions with their healthcare provider before starting Abemaciclib.
• Allergies: Inform your healthcare provider about any known allergies or sensitivities, as Abemaciclib may contain inactive ingredients that can cause allergic reactions.

Always follow your healthcare provider’s instructions and inform them about your complete medical history to ensure safe and effective treatment with Abemaciclib. Additionally, be vigilant about any potential side effects and report them promptly to your healthcare team.

What special dietary instructions should I follow?

As of last update, there were no specific dietary restrictions associated with Abemaciclib. However, it’s always advisable to discuss your diet with your healthcare provider, as they can provide personalized advice based on your overall health and potential interactions with specific foods.

What should I do if I forget a dose?

If you forget to take a dose of Abemaciclib, the general guidance is as follows:

• If it’s within 6 hours of the scheduled time:
  • Take the missed dose as soon as you remember.
  • Take the next dose at the regularly scheduled time.
• If it’s more than 6 hours until the next dose:
  • Skip the missed dose.
  • Take the next dose at the regularly scheduled time.

What side effects can this medication cause?

Abemaciclib is a medication used for the treatment of certain types of breast cancer. Like all medications, it can cause side effects, and it’s important to be aware of them. Keep in mind that not everyone will experience these side effects, and some people may experience side effects that are not listed. Common side effects of abemaciclib include:

• Gastrointestinal Issues: Abemaciclib commonly causes diarrhea, which can be severe in some cases. It’s important to inform your healthcare provider if you experience persistent or severe diarrhea.
• Fatigue: Feeling tired or experiencing weakness is a common side effect.
• Decreased Appetite: Some individuals may experience a reduced desire to eat.
• Nausea and Vomiting: These symptoms may occur, but they are usually mild.
• Increased Liver Enzymes: Abemaciclib can affect liver function, leading to an increase in liver enzyme levels. Regular monitoring of liver function is usually done during treatment.
• Infections: There is an increased risk of infections, and it’s important to promptly report any signs of infection, such as fever or persistent sore throat, to your healthcare provider.
• Low Blood Cell Counts: Abemaciclib can cause a decrease in the number of white blood cells, red blood cells, and platelets. This can result in an increased risk of infection, anemia, and bleeding. Regular blood tests are typically conducted to monitor blood cell counts.
• Hair Loss: Some individuals may experience hair loss.

It’s crucial to communicate with your healthcare provider about any side effects you may be experiencing. They can provide guidance on managing side effects and may adjust your treatment plan if necessary. Additionally, it’s important to report any severe or persistent side effects promptly.

This information is not exhaustive, and individual responses to medications can vary. Always consult with your healthcare provider for personalized advice and information based on your specific health condition.

What should I know about storage and disposal of this medication?

Storage of Abemaciclib:

• Temperature: Store Abemaciclib at room temperature between 68°F to 77°F (20°C to 25°C).
• Protection from Light: Keep the medication in its original container, and protect it from light.
• Keep Out of Reach of Children: Store Abemaciclib in a location where children cannot access it.

Disposal of Abemaciclib:

• Follow Guidelines: Dispose of Abemaciclib according to local guidelines and regulations. Do not flush it down the toilet or throw it in the trash unless instructed to do so.
• Take-Back Programs: Check if there are any medication take-back programs or facilities in your area where you can safely dispose of unused or expired medications.

In case of emergency/overdose

If you suspect an overdose or experience severe side effects, seek emergency medical attention or contact a poison control center immediately. Symptoms of an overdose may include severe diarrhea, vomiting, and other adverse reactions.

What other information should I know?

• Regular Follow-up: Attend all scheduled follow-up appointments with your healthcare provider for monitoring and adjustments to your treatment plan if necessary.
• Lab Tests: Your healthcare provider may order regular blood tests to monitor your blood cell counts and liver function during Abemaciclib treatment.
• Inform Healthcare Providers: Keep all healthcare providers informed about your use of Abemaciclib, including specialists and dentists. Mention the medication before any medical procedures or surgeries.
• Avoid Grapefruit: Avoid consuming grapefruit or grapefruit juice while taking Abemaciclib, as it may interact with the medication.

Always follow the specific instructions provided by your healthcare provider and the medication packaging. If you have any questions or concerns about the storage, disposal, or usage of Abemaciclib, consult your healthcare provider or pharmacist for clarification. It’s essential to have a comprehensive understanding of your treatment plan and to communicate openly with your healthcare team.