Why is this medication prescribed?

Valchlor is a medication that contains the active ingredient mechlorethamine, which belongs to a class of drugs known as alkylating agents. It is primarily prescribed for the topical treatment of a type of skin cancer called mycosis fungoides, which is a form of cutaneous T-cell lymphoma (CTCL). CTCL is a rare type of non-Hodgkin’s lymphoma that affects the skin.

Valchlor is applied topically as a gel, and its active ingredient, mechlorethamine, works by interfering with the growth of cancer cells. It is used when the disease is limited to the skin and hasn’t responded well to other forms of treatment or when other treatment options are not suitable.

How should this medicine be used?

Valchlor (mechlorethamine) is a topical medication used for the treatment of mycosis fungoides, a type of cutaneous T-cell lymphoma. It is applied directly to the skin as a gel. Here are general guidelines for using Valchlor:

• Application Site Preparation: Prior to applying Valchlor, make sure the skin is clean and dry. Do not apply the medication to areas of the skin that are actively inflamed or infected.
• Application Procedure: Apply a thin layer of Valchlor gel to the affected areas of the skin once daily. Use enough gel to cover the entire area, but avoid applying excess amounts.
• Avoid Contact with Eyes, Nose, and Mouth: Take care to avoid getting Valchlor gel in the eyes, nose, mouth, or other mucous membranes. If accidental contact occurs, rinse thoroughly with water.
• Gloves and Hand Washing: Wear disposable nitrile gloves when applying Valchlor to avoid direct skin contact. After applying the gel, wash your hands thoroughly with soap and water.
• Storage: Store Valchlor gel in the refrigerator. Do not freeze. Keep the gel out of the reach of children.
• Duration of Treatment: The duration of treatment may vary depending on the response to therapy and the healthcare provider’s recommendations. Follow your healthcare provider’s instructions regarding the duration of treatment.
• Missed Doses: If a dose is missed, apply it as soon as possible. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule.
• Adverse Reactions: Report any signs of irritation, rash, or other adverse reactions to your healthcare provider.
• Follow Healthcare Provider’s Instructions: Always follow the specific instructions provided by your healthcare provider regarding the use of Valchlor.

It’s important to note that these are general guidelines, and individual patient instructions may vary. Patients should consult their healthcare provider for personalized advice and to address any specific concerns or questions related to the use of Valchlor.

Other uses for this medicine

Valchlor (mechlorethamine) is primarily approved for the topical treatment of mycosis fungoides, a type of cutaneous T-cell lymphoma. Its use for other conditions is not well-established, and you should only use it for the specific condition it is prescribed for. Off-label use should be discussed with and approved by your healthcare provider.

What special precautions should I follow?

As for special precautions, it’s crucial to follow your healthcare provider’s guidance and adhere to the prescribed dosage and application instructions. Here are some general precautions and considerations:

• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The potential risks and benefits of using Valchlor during pregnancy or breastfeeding should be discussed.
• Allergies: Inform your healthcare provider about any allergies you may have, especially if you have a known allergy to mechlorethamine or any other ingredients in Valchlor.
• Skin Conditions: Do not apply Valchlor to areas of the skin that are actively inflamed or infected. Inform your healthcare provider of any skin conditions you have before starting treatment.
• Eye Protection: Take precautions to avoid getting Valchlor gel in your eyes. If accidental contact occurs, rinse your eyes thoroughly with water.
• Gloves and Hand Washing: Always wear disposable nitrile gloves when applying Valchlor to avoid direct skin contact. Wash your hands thoroughly with soap and water after application.
• Storage: Store Valchlor in the refrigerator, and do not freeze it. Keep it out of the reach of children.
• Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. They will monitor your response to treatment and assess for any side effects or complications.
• Other Medications: Inform your healthcare provider about all prescription and over-the-counter medications, vitamins, and supplements you are taking, as Valchlor may interact with other drugs.
• Adverse Reactions: Report any signs of irritation, rash, or other adverse reactions to your healthcare provider promptly.
• Sun Exposure: Take precautions to protect treated areas from excessive sun exposure. Valchlor may increase sensitivity to sunlight.
• Disposal: Follow proper disposal instructions for Valchlor, as directed by your healthcare provider or pharmacist.

Always consult with your healthcare provider if you have any concerns or questions about the use of Valchlor. They can provide personalized guidance based on your specific medical history and condition.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Valchlor. However, it’s always a good idea to maintain a balanced and healthy diet, especially if you’re undergoing medical treatment. If you have concerns or questions about diet and Valchlor, discuss them with your healthcare provider.

What should I do if I forget a dose?

• If you forget a dose of Valchlor, apply it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
• Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Valchlor (mechlorethamine) can cause various side effects, and it’s important to be aware of them and promptly report any unusual symptoms to your healthcare provider. Not everyone will experience these side effects, and their severity can vary. Here are some potential side effects associated with Valchlor:

• Skin Reactions: Redness, itching, burning, or irritation at the application site.
• Contact Dermatitis: Allergic reactions or contact dermatitis may occur. This can include rash, hives, or swelling.
• Photosensitivity: Increased sensitivity to sunlight, leading to sunburn more easily. It’s important to take precautions to protect treated areas from excessive sun exposure.
• Eye Irritation: Valchlor can cause irritation if it comes into contact with the eyes. Avoid getting the gel in your eyes, and if accidental exposure occurs, rinse thoroughly with water.
• Secondary Infections: There is a risk of bacterial or fungal infections in the treated skin areas. Report any signs of infection, such as increased redness, swelling, or discharge, to your healthcare provider.
• Hematologic Effects: Changes in blood cell counts, such as a decrease in white blood cell count (neutropenia). Regular blood tests may be performed to monitor for these effects.
• Systemic Absorption: Although Valchlor is applied topically, there is a potential for systemic absorption, which may lead to systemic effects. This is more likely with prolonged use or application to large areas of the skin.
• Allergic Reactions: Serious allergic reactions are rare but possible. Seek medical attention if you experience symptoms such as difficulty breathing, severe dizziness, or swelling of the face, lips, or tongue.

It’s important to note that this is not an exhaustive list of side effects, and individual reactions can vary. Some side effects may be temporary and resolve on their own, while others may require medical attention. Always inform your healthcare provider if you experience any unusual or persistent symptoms while using Valchlor.

Additionally, discuss the potential side effects with your healthcare provider before starting Valchlor, and follow their recommendations for monitoring and managing side effects during the course of treatment.

What should I know about storage and disposal of this medication?

Storage and Disposal of Valchlor:

• Storage: Valchlor (mechlorethamine) gel should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C). Do not freeze the medication. Keep it in its original carton to protect it from light.
• Children and Pets: Store Valchlor out of the reach of children and pets.
• Disposal: Follow your healthcare provider’s or pharmacist’s instructions on how to properly dispose of unused or expired Valchlor. Do not dispose of medications in wastewater or household waste unless instructed to do so.

In case of emergency/overdose

• In the case of accidental ingestion, seek emergency medical attention immediately.
• If excessive topical application occurs, wash the affected area thoroughly and contact your healthcare provider.

What other information should I know?

• Follow Instructions: Always use Valchlor as prescribed by your healthcare provider. Follow the specific instructions regarding application, dosage, and duration of treatment.
• Avoid Contact with Eyes and Mucous Membranes: Take care to avoid contact with eyes, nose, mouth, and other mucous membranes. If accidental exposure occurs, rinse thoroughly with water.
• Gloves and Handwashing: Use disposable nitrile gloves when applying Valchlor. Wash hands thoroughly with soap and water after application.
• Sun Protection: Valchlor may increase sensitivity to sunlight. Take precautions to protect treated areas from excessive sun exposure.
• Regular Follow-ups: Attend all scheduled follow-up appointments with your healthcare provider. They will monitor your response to treatment and assess for any side effects or complications.
• Inform Healthcare Provider: Keep your healthcare provider informed about all medications, including over-the-counter drugs and supplements, that you are taking.

Always consult with your healthcare provider or pharmacist if you have any questions or concerns about the storage, disposal, or usage of Valchlor. They can provide personalized guidance based on your specific medical history and condition. If you suspect an overdose or encounter an emergency, seek immediate medical attention.