WARNING

Taking Unituxin (dinutuximab) involves certain risks, as with any medical treatment. The risks associated with Unituxin can vary from person to person, and not everyone will experience the same side effects. Here is a brief overview of potential risks:

• Allergic Reactions: Unituxin can cause allergic reactions, ranging from mild to severe. Symptoms may include rash, itching, and, in severe cases, difficulty breathing. Close monitoring during and after infusion is done to detect and manage any allergic reactions.
• Infusion-Related Reactions: Some individuals may experience reactions during the infusion, such as fever, chills, or changes in blood pressure. Pre-medications are often given to reduce the risk of these reactions.
• Capillary Leak Syndrome: This is a serious side effect that involves the leakage of fluid from blood vessels into surrounding tissues. It can lead to swelling, low blood pressure, and other symptoms.
• Peripheral Neuropathy: Nerve damage, leading to symptoms such as tingling, numbness, or pain in the hands and feet, can occur.
• Pain and Discomfort: Patients may experience pain or discomfort, including abdominal pain and bone pain.
• Hypotension (Low Blood Pressure): Unituxin can cause a drop in blood pressure, leading to symptoms such as dizziness or lightheadedness.
• Infections: There may be an increased risk of infections due to the impact of treatment on the immune system.
• Liver Function Changes: Unituxin may affect liver function, leading to changes in liver enzyme levels.

It’s crucial for patients and their caregivers to be aware of these potential risks and to promptly report any new or worsening symptoms to healthcare providers. The decision to use Unituxin is typically based on a careful assessment of the potential benefits against the risks, and healthcare professionals closely monitor patients during treatment to manage and mitigate these risks. Always consult with your healthcare provider for personalized information and guidance based on your specific health situation.

Why is this medication prescribed?

Unituxin (dinutuximab) is prescribed for the treatment of neuroblastoma, a type of cancer that primarily affects children. Neuroblastoma is a cancer that develops from immature nerve cells and is often found in the adrenal glands, which are located on top of the kidneys.

The specific indications for Unituxin use in neuroblastoma include:

• High-Risk Neuroblastoma: Unituxin is typically used in combination with other therapies for the treatment of high-risk neuroblastoma. High-risk neuroblastoma refers to cases where the cancer is aggressive and has a higher likelihood of recurrence.
• Post-Induction Consolidation Therapy: Unituxin is often prescribed as part of post-induction consolidation therapy. This means it is given after the initial phase of treatment, which may include surgery and chemotherapy, to consolidate the gains made and reduce the risk of cancer recurrence.
• Immunotherapy: Unituxin is a monoclonal antibody, a type of immunotherapy. It works by targeting specific molecules on the surface of neuroblastoma cells, promoting the immune system’s recognition and destruction of these cancer cells.

How should this medicine be used?

The use of Unituxin (dinutuximab) is typically guided by a healthcare professional, usually a pediatric oncologist, and the administration of the medication involves several steps. It’s important to note that the specific details of treatment may vary based on the individual patient’s condition, and the following information provides a general overview:

• Administration: Unituxin is administered intravenously (IV), meaning it is delivered directly into the bloodstream through a vein. The medication is usually given as part of a combination therapy for high-risk neuroblastoma.
• Pre-Medication: Before receiving Unituxin, patients may be given pre-medications to help manage potential side effects, such as allergic reactions. These pre-medications are typically administered before the Unituxin infusion.
• Treatment Schedule: The treatment schedule, including the frequency and duration of Unituxin infusions, is determined by the healthcare provider based on the specific treatment plan for the individual patient. Infusions are often given over several hours and may be repeated for several days in a row.
• Monitoring: During and after the infusion, healthcare professionals closely monitor the patient for any signs of adverse reactions or side effects. Regular monitoring and follow-up appointments are scheduled to assess the patient’s response to treatment and address any concerns.
• Supportive Care: Supportive care measures, such as managing side effects and providing medications to alleviate symptoms, may be incorporated into the overall treatment plan.
• Multidisciplinary Approach: Unituxin is typically used as part of a multidisciplinary approach to treating neuroblastoma, which may include surgery, chemotherapy, stem cell transplant, and other interventions.

Patients and their caregivers should always follow the specific instructions provided by the healthcare team. It’s essential to communicate openly with the healthcare provider about any concerns, side effects, or changes in the patient’s condition. Additionally, adherence to the prescribed treatment plan and attending scheduled follow-up appointments is crucial for the effectiveness of the therapy.

Other uses for this medicine

Unituxin is primarily indicated for the treatment of high-risk neuroblastoma and is not approved for other uses. Its use is specific to the treatment of this pediatric cancer. Always consult with healthcare professionals for the latest information on drug indications.

What special precautions should I follow?

As for special precautions, it’s important to note that medication guidelines and safety information may evolve, so it’s essential to consult with a healthcare professional for the most up-to-date and relevant information. Here are some general precautions associated with the use of Unituxin:

• Allergic Reactions: Patients may be at risk of allergic reactions to Unituxin. It’s crucial to inform healthcare providers about any known allergies or reactions to medications.
• Monitoring: Patients receiving Unituxin are typically closely monitored during and after the infusion for any signs of adverse reactions or side effects. Monitoring may include vital signs, laboratory tests, and other assessments.
• Pre-Medication: Pre-medications are often given to manage potential side effects or allergic reactions. Adherence to the prescribed pre-medications is important.
• Infection Risk: As with many cancer treatments, there may be an increased risk of infections. Patients should report any signs of infection, such as fever or persistent cough, to their healthcare provider promptly.
• Neuropathic Pain: Some patients may experience neuropathic pain as a side effect. Adequate pain management strategies may be employed as part of the treatment plan.
• Hypotension (Low Blood Pressure): Unituxin can cause low blood pressure, and patients may be closely monitored for this effect during administration. Supportive measures may be taken to manage hypotension if it occurs.
• Liver Function: Regular monitoring of liver function may be necessary during treatment with Unituxin.

It’s crucial for patients and their caregivers to communicate openly with the healthcare team, report any symptoms or concerns promptly, and adhere to the prescribed treatment plan. Additionally, healthcare professionals will provide specific guidance based on the individual patient’s health status and medical history.

As practices and guidelines can change, it’s advisable to consult with a healthcare professional for the most current information and recommendations regarding the use of Unituxin.

What special dietary instructions should I follow?

There may not be specific dietary instructions associated with Unituxin. However, it’s essential to maintain a healthy and balanced diet to support overall well-being. If you have any dietary concerns or restrictions, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

Since Unituxin is typically administered by healthcare professionals, it’s less likely for a patient to forget a dose. However, if you have concerns about a missed dose, contact your healthcare provider or the medical facility where the treatment was scheduled. It’s important not to self-administer medications or try to make up for a missed dose without guidance from your healthcare team.

What side effects can this medication cause?

Unituxin (dinutuximab) can cause various side effects, and it’s important for patients and their caregivers to be aware of potential reactions. Keep in mind that the severity and occurrence of side effects can vary from person to person. Common side effects of Unituxin include:

• Pain or Discomfort: Patients may experience pain or discomfort, including abdominal pain, bone pain, or pain at the infusion site.
• Fever: Fever is a common side effect and may be associated with the infusion of Unituxin.
• Low Blood Pressure (Hypotension): Unituxin can cause a drop in blood pressure, and patients may experience symptoms such as dizziness or lightheadedness.
• Reactions During Infusion: Some individuals may experience infusion-related reactions, including allergic reactions. These can include rash, itching, or difficulty breathing. Healthcare providers often administer pre-medications to reduce the risk of these reactions.
• Capillary Leak Syndrome: This is a serious side effect that can occur with Unituxin. It involves the leakage of fluid from blood vessels into surrounding tissues, leading to swelling, low blood pressure, and other symptoms.
• Nerve Damage (Peripheral Neuropathy): Peripheral neuropathy may occur, causing symptoms such as tingling, numbness, or pain in the hands and feet.
• Infections: There may be an increased risk of infections due to the impact of treatment on the immune system.
• Liver Enzyme Changes: Unituxin may affect liver function, leading to changes in liver enzyme levels.
• Hypersensitivity Reactions: Severe allergic reactions are possible, and these can be life-threatening. Immediate medical attention is required for any signs of a severe allergic reaction, such as difficulty breathing or swelling of the face and throat.

It’s important to note that this is not an exhaustive list of side effects, and other side effects may occur. Patients should promptly report any new or worsening symptoms to their healthcare provider. The healthcare team will monitor for potential side effects and take appropriate measures to manage and mitigate them.

If you or someone you know is undergoing treatment with Unituxin, it’s crucial to maintain open communication with the healthcare team to ensure that side effects are promptly addressed, and appropriate supportive care measures are implemented.

What should I know about storage and disposal of this medication?

Storage and Disposal of Unituxin:

• Storage:
  • Unituxin is typically administered in a healthcare setting, and the storage of the medication is the responsibility of the healthcare facility.
  • If you are given any instructions or supplies related to at-home care, follow them closely.
• Disposal:
  • Proper disposal of medical waste, including empty vials or infusion materials, should be carried out according to the guidelines provided by healthcare professionals or local regulations.
  • Do not dispose of medical waste in regular household trash without proper guidance.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek immediate medical attention. Emergency services should be contacted right away. Symptoms of an overdose or severe reaction may include:

• Difficulty breathing
• Swelling of the face, lips, or tongue
• Severe rash or itching
• Chest pain
• Severe abdominal pain
• Uncontrolled bleeding

What other information should I know?

• Regular Monitoring: Patients receiving Unituxin will undergo regular monitoring during and after the infusion to check for any adverse reactions or side effects.
• Follow-Up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. These visits are important for assessing treatment response, managing side effects, and adjusting the treatment plan if necessary.
• Communication: Maintain open and clear communication with your healthcare team. Report any new or worsening symptoms, concerns, or changes in your condition promptly.
• Pre-Medications: If your healthcare provider has prescribed pre-medications to manage potential side effects, ensure that you take them as directed.
• Supportive Care: Follow any instructions for supportive care measures, such as pain management or infection prevention strategies.
• Allergic Reactions: Be vigilant for signs of allergic reactions, such as rash, itching, or difficulty breathing. Report any such symptoms immediately to your healthcare provider.
• Immunizations: Inform your healthcare provider about any vaccinations you have received or plan to receive, as certain vaccinations may need to be delayed during treatment.

It’s essential to remember that the information provided here is general, and specific guidance may vary based on individual patient circumstances. Always consult with your healthcare provider for personalized information and follow their recommendations closely. If you have any questions or concerns, do not hesitate to discuss them with your healthcare team.