WARNING

Trulicity is a prescription medication primarily used to treat type 2 diabetes. Like any medication, it carries certain risks and side effects. Here’s a brief overview of some potential risks associated with taking Trulicity:

• Hypoglycemia: Trulicity can lower blood sugar levels, which may lead to hypoglycemia (low blood sugar). Symptoms of hypoglycemia include shakiness, dizziness, sweating, confusion, and in severe cases, loss of consciousness.
• Gastrointestinal Effects: Common side effects of Trulicity include nausea, vomiting, diarrhea, and stomach pain. These symptoms typically improve over time but can be bothersome for some individuals.
• Pancreatitis: There have been reports of pancreatitis (inflammation of the pancreas) associated with the use of Trulicity. Symptoms include severe abdominal pain, nausea, and vomiting. If left untreated, pancreatitis can be serious and even life-threatening.
• Thyroid Tumors: Studies in animals have shown an increased risk of thyroid tumors with the use of Trulicity. While this risk hasn’t been confirmed in humans, it’s still a potential concern.
• Allergic Reactions: Some people may experience allergic reactions to Trulicity, which can manifest as rash, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat. These reactions require immediate medical attention.
• Kidney Problems: Trulicity may affect kidney function, particularly in individuals with pre-existing kidney disease. It’s important for healthcare providers to monitor kidney function regularly in patients taking this medication.
• Injection Site Reactions: Trulicity is administered via subcutaneous injection, which can cause injection site reactions such as redness, swelling, or itching.
• Bone Fractures: There’s some evidence suggesting that Trulicity may increase the risk of bone fractures, particularly in older adults or those with pre-existing bone conditions.

It’s essential for individuals considering or using Trulicity to discuss these potential risks with their healthcare provider. They can provide personalized guidance based on the individual’s medical history and specific health needs.

Why is this medication prescribed?

Trulicity (generic name: dulaglutide) is primarily prescribed for the management of type 2 diabetes mellitus. It belongs to a class of medications called GLP-1 receptor agonists, which work by mimicking the action of the incretin hormone glucagon-like peptide-1 (GLP-1). Trulicity helps to lower blood sugar levels in people with type 2 diabetes by stimulating insulin secretion, inhibiting glucagon release (which reduces blood sugar production), slowing gastric emptying, and promoting feelings of satiety.

Trulicity is typically prescribed when lifestyle changes (such as diet and exercise) alone are not sufficient to control blood sugar levels, or when other oral medications for diabetes management have not provided adequate glycemic control. It is often used as part of a comprehensive treatment plan for diabetes management and is usually taken alongside other antidiabetic medications.

In summary, Trulicity is prescribed to:

• Lower blood sugar levels in adults with type 2 diabetes mellitus.
• Improve glycemic control when diet and exercise alone are not sufficient.
• Reduce the risk of complications associated with uncontrolled diabetes, such as cardiovascular disease, kidney damage, nerve damage, and eye problems.

How should this medicine be used?

Trulicity (dulaglutide) is a medication for type 2 diabetes that is typically administered once weekly via subcutaneous injection. Here’s a general guideline on how Trulicity should be used:

• Dosage: Trulicity is available in prefilled pens containing doses of 0.75 mg or 1.5 mg. The starting dose for most people is 0.75 mg once weekly. However, your healthcare provider may adjust the dosage based on your individual needs and response to the medication.
• Administration: Trulicity is injected subcutaneously (under the skin) into the abdomen, thigh, or upper arm. It’s important to rotate injection sites to reduce the risk of injection site reactions.
• Injection Technique: Before administering Trulicity, wash your hands thoroughly with soap and water. Choose a clean injection site, and wipe the skin with an alcohol swab. Allow the skin to dry before injecting. Hold the pen at a 90-degree angle to the skin and administer the injection according to the instructions provided by your healthcare provider or the medication package insert.
• Timing: Trulicity should be administered on the same day each week, at any time of the day, with or without food. It’s important to maintain a consistent dosing schedule to ensure optimal blood sugar control.
• Storage: Trulicity pens should be stored in the refrigerator at a temperature between 36°F to 46°F (2°C to 8°C). However, they can be kept at room temperature (up to 86°F or 30°C) for up to 14 days before use. Once in use, the pen can be kept at room temperature and should be discarded after 14 days, even if it still contains medication.
• Monitoring: While taking Trulicity, it’s essential to monitor your blood sugar levels regularly as directed by your healthcare provider. They may also monitor other parameters such as kidney function, weight, and any potential side effects.
• Compliance: It’s crucial to use Trulicity exactly as prescribed by your healthcare provider. Do not change your dosage or frequency without consulting them first. If you miss a dose, take it as soon as you remember unless it’s close to the time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule.

Always follow the instructions provided by your healthcare provider and the medication package insert when using Trulicity. If you have any questions or concerns about how to use Trulicity, don’t hesitate to discuss them with your healthcare provider or pharmacist.

Other uses for this medicine

As for other uses for Trulicity, while its primary indication is for type 2 diabetes, there may be instances where it is prescribed off-label for other conditions. However, using Trulicity for anything other than its intended purpose should only be done under the guidance and supervision of a healthcare professional.

What special precautions should I follow?

Regarding special precautions for Trulicity, here are some important points to consider:

• Allergies: Inform your healthcare provider if you have a known allergy to dulaglutide or any other ingredients in Trulicity. Allergic reactions can be serious and may require immediate medical attention.
• Pancreatitis: Trulicity has been associated with an increased risk of pancreatitis (inflammation of the pancreas). Inform your healthcare provider if you have a history of pancreatitis or if you experience severe abdominal pain, nausea, or vomiting while taking Trulicity.
• Thyroid Tumors: Trulicity has been shown to increase the risk of thyroid tumors in animal studies. Although this risk hasn’t been confirmed in humans, it’s important to discuss any history of thyroid problems with your healthcare provider.
• Kidney Function: Trulicity may affect kidney function, particularly in individuals with pre-existing kidney disease. Your healthcare provider may need to monitor your kidney function regularly while you are taking Trulicity.
• Gastrointestinal Effects: Trulicity commonly causes gastrointestinal side effects such as nausea, vomiting, diarrhea, and stomach pain. These symptoms usually improve over time but inform your healthcare provider if they become severe or persistent.
• Hypoglycemia: Trulicity can lower blood sugar levels, leading to hypoglycemia (low blood sugar). It’s important to monitor your blood sugar levels regularly and be aware of the symptoms of hypoglycemia, such as shakiness, dizziness, sweating, confusion, and hunger.
• Injection Site Reactions: Trulicity is administered via subcutaneous injection and may cause injection site reactions such as redness, swelling, or itching. Rotate injection sites and inform your healthcare provider if you experience any persistent or severe reactions.
• Other Medications: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as they may interact with Trulicity.

Always follow your healthcare provider’s instructions and advice when taking Trulicity, and do not hesitate to ask any questions or express concerns you may have about its use.

What special dietary instructions should I follow?

Special Dietary Instructions:

• Consistent Meal Timing: Try to maintain a consistent schedule for meals and snacks to help manage blood sugar levels.
• Healthy Eating: Follow a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats. Limit intake of sugary foods and beverages.
• Alcohol: Limit alcohol consumption as it can affect blood sugar levels and increase the risk of hypoglycemia.
• Hydration: Drink plenty of water to stay hydrated, as dehydration can affect blood sugar control.

What should I do if I forget a dose?

• Missed Weekly Dose: If you forget to take your Trulicity dose on the scheduled day, you can take it as soon as you remember, as long as it’s within three days (72 hours) of the missed dose. If more than three days have passed, skip the missed dose and take the next scheduled dose as usual.
• Contact Healthcare Provider: If you’re unsure about what to do after missing a dose or if you have any concerns, contact your healthcare provider for guidance.
• Avoid Double Dosing: Do not take a double dose of Trulicity to make up for a missed dose.

What side effects can this medication cause?

Trulicity (dulaglutide) can cause a variety of side effects, although not everyone will experience them. Common side effects of Trulicity may include:

• Nausea: Feeling nauseous or queasy is a common side effect, especially when starting Trulicity. This symptom often improves over time as your body adjusts to the medication.
• Diarrhea: Some people may experience loose stools or diarrhea while taking Trulicity.
• Vomiting: Vomiting can occur as a side effect of Trulicity, particularly during the initial weeks of treatment.
• Abdominal Pain: Mild to moderate abdominal discomfort or pain may occur.
• Decreased Appetite: Trulicity can sometimes reduce appetite, leading to decreased food intake.
• Injection Site Reactions: Redness, swelling, itching, or pain at the injection site are possible side effects of Trulicity. Rotating injection sites can help minimize these reactions.
• Hypoglycemia: Trulicity can lower blood sugar levels, increasing the risk of hypoglycemia (low blood sugar). Symptoms may include shakiness, sweating, confusion, and hunger.
• Headache: Some people may experience headaches while taking Trulicity.
• Fatigue: Feeling tired or fatigued is a possible side effect of Trulicity.
• Dizziness: Trulicity can occasionally cause dizziness or lightheadedness.
• Constipation: While less common than diarrhea, some individuals may experience constipation as a side effect.
• Increased Heart Rate: Trulicity may cause an increase in heart rate (tachycardia) in some people.
• Allergic Reactions: Although rare, allergic reactions to Trulicity can occur. Symptoms may include rash, itching, swelling of the face or throat, and difficulty breathing.
• Pancreatitis: In rare cases, Trulicity may be associated with pancreatitis, characterized by severe abdominal pain, nausea, and vomiting.
• Thyroid Tumors: Studies in animals have shown an increased risk of thyroid tumors with Trulicity, although this risk has not been confirmed in humans.

It’s important to report any side effects you experience while taking Trulicity to your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment plan if necessary. Additionally, seek medical attention immediately if you experience severe or concerning symptoms, such as signs of allergic reactions or pancreatitis.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Store Trulicity pens in the refrigerator at a temperature between 36°F to 46°F (2°C to 8°C). Do not freeze. Keep Trulicity pens in their original carton to protect them from light. Once in use, the pen can be kept at room temperature (up to 86°F or 30°C) for up to 14 days.
• Avoid Exposure to Extreme Temperatures: Do not expose Trulicity pens to temperatures above 86°F (30°C) or direct sunlight. Additionally, do not freeze Trulicity pens.
• Do Not Use Expired Medication: Check the expiration date on the Trulicity pen before each use. Do not use Trulicity if it has expired.
• Disposal: Dispose of used Trulicity pens in accordance with local regulations. Do not dispose of Trulicity pens in household trash or recycling bins. Your healthcare provider or pharmacist can provide guidance on proper disposal methods.

In case of emergency/overdose

• Seek Medical Attention: In case of an overdose or emergency, such as severe hypoglycemia (low blood sugar) or allergic reactions, seek immediate medical assistance by calling emergency services (e.g., 911 in the United States) or going to the nearest emergency room.
• Symptoms of Overdose: Symptoms of Trulicity overdose may include severe hypoglycemia, gastrointestinal symptoms (such as nausea and vomiting), and allergic reactions. If you suspect an overdose, do not attempt to treat it at home; seek professional medical help immediately.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Take Trulicity exactly as prescribed by your healthcare provider. Do not change your dose or dosing schedule without consulting them first.
• Regular Monitoring: Your healthcare provider may recommend regular monitoring of blood sugar levels, kidney function, and other parameters while you are taking Trulicity.
• Medication Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as they may interact with Trulicity.
• Patient Education: Understand how to properly administer Trulicity injections and rotate injection sites to minimize discomfort and injection site reactions.
• Diet and Exercise: Follow your healthcare provider’s recommendations regarding diet and exercise while taking Trulicity to help manage your diabetes effectively.
• Medical Alert: Inform healthcare providers that you are taking Trulicity if you require medical treatment or undergo surgery.

Always consult your healthcare provider or pharmacist if you have any questions or concerns about the storage, disposal, emergency procedures, or any other aspect of Trulicity use.