WARNING

Rexulti (brexpiprazole) is a medication primarily used to treat schizophrenia and major depressive disorder. Like any medication, it comes with potential risks and side effects. It’s crucial to note that individual responses to medications can vary, and the decision to use Rexulti should be made in consultation with a healthcare professional who can assess the specific situation.

Some common side effects of Rexulti include:

• Akathisia: This is a condition characterized by inner restlessness and a compelling need to move.
• Weight Gain: Some individuals may experience weight gain while taking Rexulti.
• Sleepiness or Fatigue: Rexulti may cause drowsiness or fatigue, affecting the ability to perform certain activities.
• Increased Blood Sugar Levels: There is a potential risk of elevated blood sugar levels, which could be a concern, especially for individuals with diabetes.
• Increased Cholesterol Levels: Rexulti may lead to an increase in cholesterol levels.
• Orthostatic Hypotension: This refers to a drop in blood pressure upon standing, which could lead to dizziness or fainting.
• Restlessness or Impaired Judgment: Some people may experience restlessness, agitation, or impaired judgment.
• Seizures: Though rare, there have been reports of seizures associated with Rexulti use.

It’s important to be aware of and discuss these potential risks with a healthcare provider before starting Rexulti. They can provide more personalized information based on an individual’s health history, current medications, and specific conditions. Additionally, any unusual or severe side effects should be reported to a healthcare professional promptly. Always follow the prescribed dosage and never stop taking the medication without consulting a healthcare provider, as sudden discontinuation can lead to withdrawal symptoms or a return of symptoms being treated.

Why is this medication prescribed?

Rexulti (brexpiprazole) is a medication that belongs to a class of drugs known as atypical antipsychotics. It is primarily prescribed for the treatment of two main conditions:

• Schizophrenia: Rexulti is used to treat schizophrenia, a mental disorder characterized by distorted thinking, hallucinations, delusions, and disrupted behavior.
• Major Depressive Disorder (MDD): Rexulti is also prescribed as an adjunctive (additional) treatment to antidepressants for adults with major depressive disorder. It is meant to help improve mood when used alongside an antidepressant.

The exact way Rexulti works is not fully understood, but it is believed to affect the activity of certain neurotransmitters in the brain, such as serotonin and dopamine.

How should this medicine be used?

The dosage of Rexulti can vary depending on the specific condition being treated, the individual’s response to the medication, and other factors. It’s important to follow the prescribed dosage and instructions provided by the healthcare professional.

Typically, Rexulti is taken once daily, with or without food. The tablets should be swallowed whole and not crushed or chewed. The dosage may be adjusted by the healthcare provider based on the individual’s response to the medication.

Patients should not suddenly stop taking Rexulti without consulting their healthcare provider, as abrupt discontinuation can lead to withdrawal symptoms or a return of symptoms. If a dose is missed, it should be taken as soon as remembered, but if it is close to the time for the next scheduled dose, the missed dose should be skipped.

It’s crucial for individuals prescribed Rexulti to attend regular follow-up appointments with their healthcare provider to monitor the medication’s effectiveness and address any potential side effects or concerns. As with any medication, it’s essential to communicate openly with the healthcare provider about any changes in symptoms or experiences while taking Rexulti.

Other uses for this medicine

Off-label uses of Rexulti may include:

• Bipolar Disorder: Some healthcare providers may prescribe Rexulti as part of the treatment plan for bipolar disorder.
• Anxiety Disorders: There is some limited evidence suggesting potential efficacy in certain anxiety disorders, but this is not an FDA-approved use.
• Augmentation of Other Psychiatric Medications: In some cases, Rexulti may be used in combination with other psychiatric medications to enhance their effectiveness.

What special precautions should I follow?

Before taking Rexulti, it’s important to inform your healthcare provider about your complete medical history, including any pre-existing conditions and medications you are currently taking. Here are some special precautions to consider:

• Pregnancy and Breastfeeding: The safety of Rexulti during pregnancy and breastfeeding is not well established. Pregnant or breastfeeding individuals should discuss the potential risks and benefits with their healthcare provider.
• Elderly Patients: Elderly individuals may be more sensitive to the side effects of Rexulti, such as the risk of falls. The healthcare provider may adjust the dosage accordingly.
• Medical Conditions: Individuals with a history of seizures, diabetes, low white blood cell count, or conditions that may affect blood pressure should exercise caution and inform their healthcare provider.
• Alcohol and Other Substances: Combining Rexulti with alcohol or certain substances may increase the risk of side effects. It’s essential to discuss substance use with the healthcare provider.
• Neuroleptic Malignant Syndrome (NMS): NMS, a potentially life-threatening condition, has been reported with antipsychotic medications like Rexulti. Seek medical attention if symptoms such as high fever, muscle stiffness, confusion, or changes in breathing occur.
• Blood Sugar and Cholesterol Monitoring: Rexulti may affect blood sugar levels and cholesterol. Regular monitoring and management of these parameters may be necessary, especially in individuals with diabetes.

It’s crucial to follow the healthcare provider’s recommendations and attend regular check-ups to monitor for any potential side effects or complications. Never make changes to the dosage or stop taking Rexulti without consulting the healthcare provider, as abrupt discontinuation can lead to adverse effects.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Rexulti. However, it’s important to maintain a balanced and healthy diet as part of overall well-being. If you have concerns about diet and medication interactions, consult your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Rexulti, follow these general guidelines:

• Take it as soon as you remember: If it’s close to the time for your next scheduled dose, skip the missed dose and take the next one as prescribed.
• Do not double up: Do not take a double dose to make up for the missed one, as this can increase the risk of side effects.

What side effects can this medication cause?

Rexulti (brexpiprazole) may cause various side effects, and individual responses to the medication can vary. It’s important to note that not everyone will experience these side effects, and some may be more common or severe than others. Common side effects include:

• Akathisia: A feeling of inner restlessness that may result in an urge to move around.
• Weight Gain: Some individuals may experience an increase in weight.
• Somnolence (Sleepiness): Rexulti can cause drowsiness or a feeling of being overly sleepy.
• Increased Blood Sugar Levels: There is a potential risk of elevated blood sugar levels, which may be of concern, especially for individuals with diabetes.
• Increased Cholesterol Levels: Rexulti may lead to an increase in cholesterol levels.
• Orthostatic Hypotension: A drop in blood pressure upon standing, which could lead to dizziness or fainting.
• Restlessness or Impaired Judgment: Some individuals may experience restlessness, agitation, or impaired judgment.
• Seizures: Though rare, there have been reports of seizures associated with Rexulti use.

It’s important to report any unusual or severe side effects to your healthcare provider promptly. Additionally, it’s crucial to be aware of the following more serious side effects that may occur and require immediate medical attention:

• Neuroleptic Malignant Syndrome (NMS): A potentially life-threatening condition characterized by symptoms such as high fever, muscle stiffness, confusion, and changes in breathing.
• Tardive Dyskinesia: Involuntary, repetitive movements of the face or other parts of the body, which may be irreversible.
• Metabolic Changes: Antipsychotic medications like Rexulti may be associated with metabolic changes, including weight gain, elevated blood sugar levels, and lipid abnormalities.
• Suicidal Thoughts or Behavior: In some cases, antidepressant medications, including Rexulti, may be associated with an increased risk of suicidal thoughts or behavior, especially in young adults.

It’s important to weigh the potential benefits of Rexulti in treating the specific condition against the potential risks and side effects. Always take Rexulti exactly as prescribed by your healthcare provider and attend regular follow-up appointments to monitor your response to the medication. If you experience any concerning side effects, contact your healthcare provider for guidance.

What should I know about storage and disposal of this medication?

Storage and Disposal of Rexulti:

• Storage: Keep Rexulti in its original packaging and store it at room temperature, away from moisture and heat. Avoid exposing the medication to extreme temperatures. Always check the specific storage instructions on the medication packaging or consult your healthcare provider or pharmacist.
• Keep Out of Reach of Children: Store Rexulti in a location that is out of reach of children and pets to prevent accidental ingestion.
• Disposal: Dispose of unused or expired medication properly. Do not flush medications down the toilet unless instructed to do so. Check with your local pharmacy or healthcare provider for guidance on proper disposal methods.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms, seek emergency medical attention immediately. Symptoms of an overdose may include:

• Extreme drowsiness
• Uncontrollable movements or restlessness
• Difficulty breathing
• Fainting
• Seizures
• Loss of consciousness

Contact your local poison control center at 1-800-222-1222 (in the United States) for guidance in case of overdose. Provide them with information about the medication taken, the amount ingested, and the time of ingestion.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Take Rexulti exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your healthcare provider.
• Regular Follow-up Appointments: Attend regular follow-up appointments with your healthcare provider to monitor the effectiveness of the medication and discuss any concerns or side effects.
• Inform Healthcare Providers: Inform all healthcare providers, including dentists and emergency room personnel, about your use of Rexulti. This information is crucial in case of emergencies or if other medications need to be prescribed.
• Avoid Alcohol and Other Substances: Limit or avoid alcohol consumption while taking Rexulti. Discuss the use of other substances with your healthcare provider, as certain interactions may occur.
• Inform About Other Medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Rexulti with your healthcare provider.
• Driving and Operating Machinery: Rexulti may cause drowsiness or other side effects that can impair your ability to drive or operate machinery. Use caution until you know how the medication affects you.

Always consult with your healthcare provider or pharmacist for personalized information and guidance based on your specific health condition and needs.