Why is this medication prescribed?

Renvela is a brand name for sevelamer carbonate, a medication prescribed for the control of serum phosphorus in patients with chronic kidney disease (CKD) on dialysis. It is often used in individuals with end-stage renal disease (ESRD) who are undergoing hemodialysis or peritoneal dialysis.

Sevelamer carbonate is a phosphate binder that works by binding to dietary phosphorus in the digestive tract, preventing its absorption into the bloodstream. This helps to lower elevated levels of phosphorus in the blood, which is a common issue in people with kidney disease.

How should this medicine be used?

Here are some general guidelines for using Renvela:

• Dosage: The dosage of Renvela can vary based on individual patient needs. Your doctor will determine the appropriate dosage for you.
• Administration: Renvela is typically taken with meals. The tablets should be chewed thoroughly or crushed before swallowing. Alternatively, the powder form of Renvela can be mixed with a small amount of water or other liquids and taken with meals.
• Consistency: It’s important to take Renvela consistently with each meal to effectively control phosphorus levels. Missing doses may result in elevated phosphorus levels.
• Follow your doctor’s instructions: Always follow your doctor’s instructions regarding the dosage and timing of Renvela. If you have any questions or concerns about your medication, consult your healthcare provider.
• Monitoring: Regular monitoring of serum phosphorus levels and other laboratory parameters is typically done by healthcare professionals to assess the effectiveness of Renvela and make any necessary dosage adjustments.

It’s important to note that individual responses to medication can vary, and only your healthcare provider can determine the appropriate treatment plan for your specific condition. If you have questions or concerns about Renvela, its usage, or any potential side effects, it’s crucial to discuss them with your healthcare provider for personalized advice.

Other uses for this medicine

Renvela is primarily used for the treatment of hyperphosphatemia (elevated levels of phosphorus in the blood) in patients with CKD on dialysis. While its primary indication is for this purpose, medications can sometimes be prescribed off-label for uses other than those approved by regulatory agencies. Any off-label use should only be done under the supervision and guidance of a healthcare professional.

What special precautions should I follow?

Special precautions for using Renvela include:

• Allergies: Inform your healthcare provider if you have allergies to sevelamer carbonate or any other ingredients in Renvela.
• Digestive Issues: Some individuals may experience gastrointestinal side effects such as nausea, vomiting, constipation, or diarrhea. If you have a history of gastrointestinal problems, inform your healthcare provider.
• Swallowing Difficulties: If you have difficulty swallowing, Renvela tablets should be crushed or chewed before swallowing. However, if you have difficulty swallowing crushed or chewed tablets, Renvela may not be suitable for you.
• Calcium Supplements: Renvela may bind to dietary calcium, leading to a decrease in calcium absorption. If you are taking calcium supplements, vitamin D, or other medications that contain calcium, consult your healthcare provider.
• Monitoring: Regular monitoring of serum phosphorus levels and other laboratory parameters is essential to ensure the medication is effectively controlling phosphorus levels without causing adverse effects.
• Pregnancy and Breastfeeding: The safety of Renvela during pregnancy and breastfeeding is not well-established. Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Interactions with Other Medications: Inform your healthcare provider about all the medications you are currently taking, including prescription and over-the-counter drugs, as well as dietary supplements. Renvela may interact with other medications.

Always follow your healthcare provider’s instructions and communicate any concerns or side effects promptly. If you have specific questions about Renvela or its use, consult with your healthcare professional for the most accurate and up-to-date information.

What special dietary instructions should I follow?

• Take with Meals: Renvela is typically taken with meals. This is important for its effectiveness in binding to dietary phosphorus during the digestive process.
• Consistent Diet: Try to maintain a consistent diet with a steady intake of phosphorus-containing foods. Sudden changes in dietary phosphorus can impact the effectiveness of Renvela.
• Phosphorus-Restricted Diet: Your healthcare provider may recommend a phosphorus-restricted diet. This may include avoiding high-phosphorus foods such as dairy products, nuts, seeds, and certain processed foods.

What should I do if I forget a dose?

• Take as Soon as Possible: If you forget to take a dose of Renvela, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
• Do Not Double Dose: Do not take a double dose to make up for a missed one. Taking too much at once can increase the risk of side effects.
• Notify Your Healthcare Provider: If you consistently forget doses or have concerns about your medication schedule, inform your healthcare provider. They can provide guidance on how to manage missed doses.

What side effects can this medication cause?

Renvela (sevelamer carbonate) is generally well-tolerated, but like any medication, it can cause side effects in some individuals. It’s important to note that not everyone will experience these side effects, and the severity can vary. Common side effects may include:

• Gastrointestinal Distress: The most common side effects of Renvela are related to the gastrointestinal tract and may include nausea, vomiting, diarrhea, constipation, and abdominal pain.
• Dyspepsia (Indigestion): Some people may experience indigestion or discomfort in the upper abdomen.
• Flatulence (Gas): Increased gas production is a possible side effect.
• Constipation: Renvela may cause constipation in some individuals.
• Allergic Reactions: While rare, allergic reactions such as itching, rash, or swelling can occur. Severe allergic reactions are extremely uncommon but should be reported to a healthcare professional immediately.
• Choking or Swallowing Difficulties: For people who have difficulty swallowing, the chewable tablets may pose a risk of choking.
• Hypophosphatemia: In some cases, Renvela may bind to phosphorus excessively, leading to low levels of phosphorus in the blood (hypophosphatemia). Regular monitoring by healthcare professionals helps to avoid this.

It’s important to contact your healthcare provider if you experience any persistent or severe side effects. Additionally, if you notice any signs of an allergic reaction, such as difficulty breathing, swelling of the face or throat, or severe rash, seek immediate medical attention.

This is not an exhaustive list of side effects, and individual responses can vary. Your healthcare provider can provide more personalized information based on your health history and current medications.

If you have concerns about the side effects of Renvela or experience any unexpected symptoms, it’s essential to discuss them with your healthcare professional. They can help assess the risks and benefits of the medication for your specific situation and provide guidance on managing side effects if they occur.

What should I know about storage and disposal of this medication?

Storage and Disposal of Renvela:

• Storage:
  • Store Renvela at room temperature away from moisture and heat.
  • Keep the medication in its original container with the lid tightly closed.
• Disposal:
  • Follow local guidelines for medication disposal. Do not flush Renvela down the toilet or pour it into a drain unless instructed to do so.
  • Dispose of unused or expired medication in a safe and environmentally friendly manner. You can check with your local pharmacy or healthcare provider for guidance on proper disposal.

In case of emergency/overdose

In the case of an emergency or suspected overdose, seek immediate medical attention. Signs of an overdose may include severe or persistent vomiting, difficulty breathing, or other serious symptoms. It’s important to:

• Contact Emergency Services: Call your local emergency number (e.g., 911 in the United States) for immediate assistance.
• Poison Control Center: Contact your local poison control center for guidance. In the United States, you can reach Poison Control at 1-800-222-1222.
• Provide Information: Be prepared to provide information about the medication, including the name (Renvela), dosage, and any other relevant details.

What other information should I know?

• Regular Monitoring: If you are prescribed Renvela, your healthcare provider will likely schedule regular blood tests to monitor serum phosphorus levels and adjust your dosage as needed.
• Follow Healthcare Provider’s Instructions: Always take Renvela exactly as prescribed by your healthcare provider. Do not change the dosage or frequency without consulting them.
• Inform Healthcare Provider: Keep your healthcare provider informed about any other medications, supplements, or changes in your health status. This helps them manage potential interactions and make necessary adjustments to your treatment plan.
• Phosphorus-Restricted Diet: Your healthcare provider may recommend a diet low in phosphorus. Follow dietary instructions provided by your healthcare team to optimize the effectiveness of Renvela.
• Regular Check-ups: Attend regular check-ups with your healthcare provider to assess the overall effectiveness of your treatment and address any concerns or side effects.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Renvela with your healthcare provider.

Always consult with your healthcare provider or pharmacist if you have specific questions or concerns about Renvela or any other medication. They can provide you with the most accurate and up-to-date information based on your individual health needs.