WARNING

Renflexis is a medication that contains the active ingredient infliximab, which is a tumor necrosis factor (TNF) blocker used to treat various autoimmune diseases such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. While Renflexis can be effective for many patients, like any medication, it comes with potential risks and side effects. It’s important to note that individual responses to the medication may vary, and not everyone will experience these issues. Some potential risks associated with taking Renflexis include:

• Infections: TNF blockers like Renflexis may increase the risk of serious infections, as they can suppress the immune system. Patients should be monitored for signs of infection, and it’s crucial to report any symptoms such as fever, chills, or persistent cough to the healthcare provider promptly.
• Malignancies: There is a slightly increased risk of certain cancers, particularly lymphoma, associated with the use of TNF blockers. Regular monitoring and discussions with healthcare professionals are essential to assess the overall risk-benefit profile.
• Heart Failure: TNF blockers may exacerbate heart failure in some patients. Individuals with a history of heart failure should be closely monitored, and the medication may need to be used with caution.
• Hepatitis B Reactivation: Patients with a history of hepatitis B may experience a reactivation of the infection while on TNF blockers. Screening for hepatitis B prior to starting Renflexis is typically recommended.
• Neurological Disorders: Rare cases of neurological disorders, such as multiple sclerosis and demyelinating disorders, have been reported in patients receiving TNF blockers. The relationship between these disorders and the medication is not fully understood.

It’s crucial for individuals considering or currently using Renflexis to discuss their medical history, potential risk factors, and any concerns with their healthcare provider. The decision to use this medication should be based on a thorough evaluation of the risks and benefits in each individual case. Regular follow-up appointments and communication with the healthcare team are essential to monitor for any potential complications.

Why is this medication prescribed?

Renflexis is a prescription medication that contains the active ingredient infliximab. It belongs to a class of drugs known as tumor necrosis factor (TNF) blockers. Renflexis is primarily prescribed to treat various autoimmune diseases characterized by excessive inflammation. Some of the conditions for which Renflexis may be prescribed include:

• Rheumatoid Arthritis: Renflexis can be used to treat moderate to severe rheumatoid arthritis in adults, either alone or in combination with methotrexate.
• Crohn’s Disease: It is used in the treatment of moderate to severe Crohn’s disease in both adults and children who haven’t responded well to other treatments.
• Ulcerative Colitis: Renflexis is prescribed for the treatment of moderate to severe ulcerative colitis in adults and children who have not responded adequately to conventional therapy.
• Ankylosing Spondylitis: It may be used to treat ankylosing spondylitis, a type of arthritis affecting the spine.
• Psoriatic Arthritis: Renflexis is indicated for the treatment of active psoriatic arthritis in adults.
• Plaque Psoriasis: In some cases, it may be prescribed for adults with chronic severe plaque psoriasis who have not responded to other therapies.

How should this medicine be used?

Renflexis is typically administered by a healthcare professional through intravenous (IV) infusion. The specific dosage and frequency depend on the condition being treated. The infusion process may take a few hours, and patients are usually monitored during and after the infusion for potential reactions.

It’s important to follow the healthcare provider’s instructions carefully and attend all scheduled appointments for infusions. In some cases, patients may receive additional medications to reduce the risk of infusion reactions.

Patients should inform their healthcare provider about any pre-existing medical conditions, ongoing medications, and concerns before starting Renflexis. Regular follow-up appointments are crucial for monitoring the response to treatment, assessing side effects, and adjusting the treatment plan if necessary.

Never self-administer Renflexis or adjust the dosage without consulting a healthcare professional. If there are any concerns or side effects during treatment, it’s essential to promptly communicate with the healthcare provider.

Other uses for this medicine

Other Uses for Renflexis:

• Behçet’s Disease: In some cases, Renflexis may be used off-label for Behçet’s disease, a rare disorder causing inflammation in various parts of the body.
• Juvenile Idiopathic Arthritis: Renflexis may be considered for juvenile idiopathic arthritis in certain cases, as determined by a healthcare professional.

What special precautions should I follow?

As for special precautions when using Renflexis, consider the following:

• Infections: Renflexis can increase the risk of serious infections. Patients should be screened for infections, including tuberculosis, before starting treatment. If an infection develops during treatment, appropriate measures should be taken.
• Immunizations: Live vaccines should generally be avoided while on Renflexis due to the risk of an inadequate response and potential for infection. Before starting Renflexis, patients should be up-to-date on all necessary vaccinations.
• Heart Failure: Renflexis may worsen heart failure. Individuals with a history of heart failure should be closely monitored during treatment.
• Hepatitis B Reactivation: Patients with a history of hepatitis B should be closely monitored, and antiviral therapy may be necessary to prevent reactivation.
• Neurological Disorders: Rare cases of neurological disorders have been reported in patients receiving TNF blockers. The relationship between these disorders and the medication is not fully understood.
• Hypersensitivity Reactions: Some patients may experience infusion reactions during or after the administration of Renflexis. Premedication with antihistamines and corticosteroids may be used to minimize these reactions.

Patients should always inform their healthcare provider about their complete medical history, including any current medications, before starting Renflexis. Regular follow-up appointments are essential for monitoring side effects, treatment response, and adjusting the treatment plan as needed. It’s crucial to promptly report any unusual symptoms or concerns to the healthcare provider during the course of treatment.

What special dietary instructions should I follow?

Renflexis does not typically have specific dietary restrictions. However, maintaining a healthy and balanced diet is generally recommended for overall well-being. If you have any dietary concerns or restrictions, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

Since Renflexis is administered by a healthcare professional through intravenous infusion, there isn’t a concern about patients forgetting a dose. The healthcare team will manage the administration schedule during your scheduled appointments.

What side effects can this medication cause?

Renflexis is a medication that contains the active ingredient infliximab, which belongs to a class of drugs called tumor necrosis factor (TNF) blockers. It is used to treat various autoimmune conditions such as rheumatoid arthritis, Crohn’s disease, ulcerative colitis, psoriasis, and ankylosing spondylitis.

Like any medication, Renflexis can have side effects, and it’s important to be aware of them. Common side effects may include:

• Infusion reactions: These can occur during or after the infusion and may include symptoms such as fever, chills, chest pain, difficulty breathing, and itching.
• Infections: TNF blockers, including infliximab, can increase the risk of infections. Serious infections, including tuberculosis and fungal infections, are possible.
• Allergic reactions: Some individuals may experience allergic reactions, which can manifest as hives, itching, swelling, and difficulty breathing.
• Blood disorders: Renflexis may affect blood cell counts, leading to conditions such as anemia, leukopenia, and thrombocytopenia.
• Liver problems: In rare cases, TNF blockers can cause liver problems, including liver damage.
• Neurological reactions: There have been reports of neurological symptoms such as seizures, multiple sclerosis-like symptoms, and optic neuritis.
• Heart failure: TNF blockers may increase the risk of heart failure.

It’s important to note that this is not an exhaustive list, and individual responses to the medication can vary. Before starting Renflexis or any other medication, it’s crucial to discuss your medical history and any concerns with your healthcare provider. They can provide personalized information based on your specific health condition and needs.

If you experience any unexpected or severe side effects while taking Renflexis, it’s essential to seek medical attention promptly.

What should I know about storage and disposal of this medication?

Storage and Disposal of Renflexis:

• Storage: Renflexis, being administered through intravenous infusion in a healthcare setting, is typically stored and prepared by healthcare professionals. Patients do not need to store the medication at home. The drug is usually stored in accordance with specific guidelines to maintain its stability and effectiveness.
• Disposal: Since Renflexis is administered in a clinical setting, any unused or expired medication will be handled and disposed of by the healthcare facility. Patients do not need to worry about disposal procedures. Follow the guidelines provided by the healthcare provider or facility for the safe and proper disposal of any materials used during the infusion.

In case of emergency/overdose

• In the case of an emergency or suspected overdose, seek immediate medical attention. It’s important to contact your healthcare provider, local poison control center, or emergency room right away.
• Overdose symptoms may include severe infections, severe allergic reactions, or other adverse effects. Prompt medical intervention is crucial.

What other information should I know?

• Regular Monitoring: Attend all scheduled appointments for Renflexis infusions. Regular monitoring is essential to assess treatment response, manage potential side effects, and make any necessary adjustments to the treatment plan.
• Inform Healthcare Providers: Keep your healthcare provider informed about any changes in your health, new medications, or concerns. Open communication helps ensure the best possible care.
• Patient Education: Understand the purpose of Renflexis, its potential benefits, and risks. Ask questions and seek clarification from your healthcare provider if you have any uncertainties.
• Supportive Care: Depending on the condition being treated, your healthcare provider may recommend additional supportive care, lifestyle modifications, or other medications. Follow these recommendations for comprehensive management.
• Follow-Up Care: Follow the post-infusion care instructions provided by your healthcare team. Report any adverse reactions or unexpected symptoms promptly.

Always adhere to your healthcare provider’s instructions and consult them if you have any concerns or questions about your Renflexis treatment. Your healthcare team is the best source of information tailored to your individual health needs and circumstances.