Why is this medication prescribed?

Regranex is a prescription medication that contains becaplermin, a recombinant human platelet-derived growth factor (rhPDGF) used to treat certain types of chronic wounds, specifically diabetic foot ulcers. It is indicated for use in conjunction with good wound care practices, such as cleaning and debriding the wound, to help promote the healing of diabetic ulcers.

Diabetic foot ulcers are a common complication of diabetes, and they can be slow to heal due to poor circulation and other factors. Regranex works by promoting cell proliferation and tissue repair, helping to accelerate the healing process.

How should this medicine be used?

Here are general guidelines for using Regranex:

• Cleaning the Wound: Before applying Regranex, it’s important to clean the wound thoroughly and remove any dead tissue (debridement) to promote a healthier wound bed.
• Application: Apply a thin layer of Regranex gel directly to the ulcerated area, covering the entire wound surface.
• Frequency: Regranex is typically applied once daily. The frequency and duration of treatment may vary based on the healthcare provider’s instructions.
• Covering the Wound: After applying Regranex, you may cover the wound with a sterile non-adherent dressing. Your healthcare provider will provide specific instructions on dressing changes.
• Monitoring and Adjustments: Your healthcare provider will monitor the progress of the wound healing and may adjust the treatment plan as needed.

It’s crucial to follow your healthcare provider’s instructions carefully and attend follow-up appointments to assess the wound’s progress. Additionally, Regranex should not be used in certain situations, such as in patients with known cancers at the application site.

As with any medication, Regranex may have potential side effects or contraindications, so it’s essential to discuss your medical history and any concerns with your healthcare provider before starting this treatment.

Other uses for this medicine

Regranex (becaplermin) is primarily indicated for the treatment of diabetic foot ulcers, and its use is generally limited to this specific medical condition. It’s important to note that the use of Regranex for other purposes or in other types of wounds has not been established, and its safety and efficacy in conditions other than diabetic foot ulcers have not been proven.

What special precautions should I follow?

Special precautions and considerations when using Regranex include:

• Cancer Risk: Regranex contains a recombinant form of human platelet-derived growth factor (PDGF), and there have been concerns about an increased risk of cancer associated with the use of growth factors. The safety of Regranex has not been established in patients with a history of cancer, and its use in areas with known malignancies should be avoided.
• Pre-existing Cancer: Regranex should not be used in patients with known malignancies at the site of application. It is important to inform your healthcare provider of any history of cancer or suspicious lesions.
• Monitoring for Adverse Effects: Patients using Regranex should be monitored for the development of any suspicious skin lesions or tumors at the application site. If such lesions occur, treatment with Regranex should be discontinued, and further evaluation is warranted.
• Allergic Reactions: Allergic reactions to Regranex or any of its components are possible. If you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek medical attention promptly.
• Pregnancy and Breastfeeding: The safety of Regranex during pregnancy and breastfeeding has not been well studied. It should be used during pregnancy only if clearly needed and under the supervision of a healthcare provider.
• Pediatric Use: The safety and effectiveness of Regranex in pediatric patients have not been established.

Always follow your healthcare provider’s instructions and inform them of your complete medical history, including any medications you are currently taking or any underlying health conditions. If you have concerns or questions about the use of Regranex, discuss them with your healthcare provider for personalized advice.

What special dietary instructions should I follow?

There are typically no specific dietary instructions associated with the use of Regranex. However, it’s essential to maintain a healthy and balanced diet to support overall healing. Proper nutrition is crucial for wound healing, and your healthcare provider may provide guidance on dietary habits that promote healing.

What should I do if I forget a dose?

If you forget to apply a dose of Regranex, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Regranex (becaplermin) may cause side effects, and it’s important to be aware of them. Common side effects are typically associated with the application site and may include:

• Localized Skin Reactions: Redness, warmth, burning, stinging, itching, and irritation at the site where Regranex is applied are common side effects. These reactions are usually mild and temporary.
• Rash: Some individuals may experience a rash at the application site.
• Eczema or Dermatitis: In some cases, patients may develop eczema or dermatitis in the area where Regranex is applied.

If you experience severe or persistent irritation, redness, or other concerning skin reactions, it’s important to contact your healthcare provider for further guidance.

In addition to these common side effects, there are some important warnings and potential serious side effects associated with Regranex:

• Cancer Risk: There have been concerns about an increased risk of cancer associated with the use of growth factors like becaplermin. While the overall risk appears to be low, it is important to discuss any history of cancer with your healthcare provider before using Regranex.
• Allergic Reactions: Although rare, allergic reactions to Regranex are possible. Seek immediate medical attention if you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Increased Infections: There have been reports of an increased rate of infections in patients using Regranex. If you notice signs of infection, such as increased redness, swelling, or discharge from the wound, contact your healthcare provider.

It’s crucial to report any unexpected or severe side effects to your healthcare provider promptly. If you have concerns or questions about the use of Regranex, discuss them with your healthcare provider for personalized advice based on your medical history and individual circumstances.

What should I know about storage and disposal of this medication?

Storage and Disposal of Regranex:

• Storage: Store Regranex at room temperature between 59°F to 86°F (15°C to 30°C). Avoid freezing. Keep the medication away from light and moisture. Do not store it in the bathroom.
• Keep Out of Reach of Children: Store Regranex in a location that is out of the reach of children and pets.
• Disposal: Dispose of unused or expired Regranex in accordance with local regulations. Do not flush medications down the toilet or pour them into a drain unless specifically instructed to do so. Proper disposal helps prevent environmental contamination.

In case of emergency/overdose

In case of an emergency or suspected overdose, contact your local poison control center or seek emergency medical attention. Overdose symptoms may include an increased risk of side effects, such as severe skin reactions or other adverse effects. If possible, bring the medication packaging or container to assist healthcare providers in providing the necessary information.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Use Regranex exactly as prescribed by your healthcare provider. Do not use more or less of it or use it more often than instructed.
• Regular Follow-up: Attend regular follow-up appointments with your healthcare provider to monitor the progress of your wound healing and to address any concerns or issues.
• Inform Healthcare Provider: Inform your healthcare provider about all medications, including over-the-counter drugs and supplements, that you are taking. This is important to avoid potential drug interactions.
• Avoid Use in Certain Situations: Do not use Regranex in areas where there is a known malignancy. If you have a history of cancer, discuss this with your healthcare provider before using Regranex.
• Allergic Reactions: Be vigilant for signs of allergic reactions, such as rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you experience these symptoms.
• Wound Care Practices: In addition to using Regranex, follow your healthcare provider’s recommendations for good wound care practices, including cleaning and debriding the wound.

Always consult with your healthcare provider or pharmacist if you have specific questions or concerns about the storage, disposal, or use of Regranex. They can provide personalized guidance based on your individual health situation.