WARNING

Regorafenib is a medication used to treat certain types of cancer, such as colorectal cancer and gastrointestinal stromal tumors. Like any medication, regorafenib comes with potential risks and side effects. It’s important to note that the information provided here is a general overview, and specific risks can vary from person to person. Always consult with a healthcare professional for personalized advice. Some common risks and side effects associated with regorafenib may include:

• Fatigue: Many individuals taking regorafenib may experience fatigue or weakness.
• Hypertension (High Blood Pressure): Regorafenib can cause an increase in blood pressure, and regular monitoring is often required.
• Hand-Foot Skin Reaction: This is a common side effect, characterized by redness, swelling, and/or pain on the palms of the hands and soles of the feet.
• Gastrointestinal Issues: Side effects such as diarrhea, nausea, vomiting, and abdominal pain can occur.
• Liver Function Abnormalities: Regorafenib may affect liver function, leading to increased liver enzymes. Regular monitoring of liver function is typically recommended.
• Bleeding: There is a risk of bleeding, and it may be more likely in individuals with a history of bleeding disorders.
• Cardiac Events: Some patients may experience cardiac issues such as myocardial infarction (heart attack) or ischemia.
• Impaired Wound Healing: Regorafenib may slow down the healing process, and caution is advised before and after surgical procedures.
• Gastrointestinal Perforations: There is a rare risk of gastrointestinal perforations, which can be a serious condition.

It’s crucial for individuals taking regorafenib to be closely monitored by their healthcare team. They should promptly report any new or worsening symptoms, and regular check-ups and laboratory tests are typically part of the monitoring process. Additionally, patients should inform their healthcare provider about all medications and supplements they are taking, as drug interactions can occur.

This information is not exhaustive, and the specific risks and benefits should be discussed thoroughly with a healthcare professional based on an individual’s medical history and condition.

Why is this medication prescribed?

Regorafenib is a medication prescribed for the treatment of certain types of cancer. It is often used when other treatments have not been effective or when the cancer has progressed despite previous treatments. The main indications for regorafenib include:

• Colorectal Cancer: Regorafenib is approved for the treatment of metastatic colorectal cancer that has not responded to standard therapies.
• Gastrointestinal Stromal Tumors (GIST): It is also used in the treatment of gastrointestinal stromal tumors that cannot be surgically removed or have metastasized.

Regorafenib is a type of targeted therapy that works by inhibiting specific proteins involved in cancer cell growth and the formation of blood vessels that supply tumors. As with any prescription medication, the use of regorafenib should be carefully monitored by a healthcare professional.

How should this medicine be used?

The specific dosage and administration of regorafenib can vary based on the type of cancer being treated and individual patient factors. It is typically taken orally in the form of tablets. Here are some general guidelines:

• Dosing Schedule: The usual recommended dose is taken once daily, with or without food.
• Duration of Treatment: Treatment with regorafenib is often continuous, and the duration depends on the individual’s response to the medication and any potential side effects.
• Regular Monitoring: Patients taking regorafenib will likely undergo regular check-ups, including blood tests, to monitor for side effects and assess the overall effectiveness of the treatment.
• Adherence to Prescription: It is essential for patients to follow their healthcare provider’s instructions carefully and take the medication as prescribed. Missing doses or adjusting the dose without medical guidance can affect the treatment’s efficacy.
• Interaction with Food and Other Medications: Some medications and foods can interact with regorafenib, potentially affecting its absorption or increasing the risk of side effects. It’s crucial to inform healthcare providers about all medications, supplements, and dietary habits.

Patients should communicate openly with their healthcare team about any concerns, side effects, or changes in their health during the course of treatment. It’s important to note that regorafenib may have significant side effects, and the decision to use this medication should be made after a thorough discussion between the patient and their healthcare provider, considering the potential benefits and risks based on the individual’s medical history and condition.

Other uses for this medicine

Regorafenib is primarily used to treat colorectal cancer and gastrointestinal stromal tumors (GIST) that have not responded to other treatments. In some cases, healthcare providers may use it “off-label” for other types of cancer, but this would be determined on a case-by-case basis.

What special precautions should I follow?

As for special precautions when using regorafenib, it’s crucial to follow your healthcare provider’s guidance closely and be aware of the following precautions:

• Medical History: Inform your healthcare provider about your complete medical history, including any pre-existing conditions, previous treatments, allergies, or surgeries.
• Pregnancy and Breastfeeding: Regorafenib can cause harm to a developing fetus. It is essential to use effective contraception during treatment, and pregnant individuals should not use regorafenib. Breastfeeding is not recommended while taking this medication.
• Liver Function: Regorafenib can affect liver function, so regular monitoring of liver enzymes is typically required during treatment.
• Blood Pressure Monitoring: Since regorafenib can cause an increase in blood pressure, regular monitoring of blood pressure is important.
• Hand-Foot Skin Reaction: Be aware of the potential for hand-foot skin reaction, which may cause redness, swelling, and/or pain on the palms of the hands and soles of the feet. Report any severe or persistent symptoms to your healthcare provider.
• Gastrointestinal Issues: Inform your healthcare provider about any gastrointestinal symptoms, such as diarrhea, nausea, vomiting, or abdominal pain.
• Bleeding Risk: Due to the potential risk of bleeding, inform your healthcare provider if you have a history of bleeding disorders or are taking medications that affect blood clotting.
• Wound Healing: If you are scheduled for surgery, discuss the use of regorafenib with your surgeon, as it may impair the healing process.
• Drug Interactions: Inform your healthcare provider about all medications, including prescription, over-the-counter, and herbal supplements, to avoid potential interactions with regorafenib.

Always take regorafenib exactly as prescribed by your healthcare provider. If you experience any side effects or have concerns during the course of treatment, promptly communicate with your healthcare team. Regular check-ups and monitoring are essential to assess both the effectiveness of the treatment and any potential adverse effects.

What special dietary instructions should I follow?

While there are no specific dietary restrictions associated with regorafenib, it’s essential to maintain a balanced and nutritious diet to support overall health. Some general tips include:

• Stay Hydrated: Adequate hydration is important, especially if you experience diarrhea or other gastrointestinal symptoms.
• Nutrient-Rich Foods: Consume a diet rich in fruits, vegetables, whole grains, and lean proteins to support your overall health and well-being.
• Limit Alcohol Intake: It’s advisable to limit alcohol consumption, as excessive alcohol can affect liver function.
• Consult Your Healthcare Provider: If you have specific dietary concerns or restrictions, consult your healthcare provider or a registered dietitian for personalized advice.

What should I do if I forget a dose?

If you forget to take a dose of regorafenib, follow these general guidelines:

• Take the Missed Dose as Soon as Possible: If you realize you missed a dose and it’s not almost time for the next scheduled dose, take it as soon as you remember.
• Skip the Missed Dose if it’s Almost Time for the Next Dose: If it’s close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
• Do Not Double Dose: Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Regorafenib, like many medications, can cause a range of side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary from person to person. Additionally, the benefits of the medication in treating cancer are weighed against the potential side effects. Common side effects of regorafenib include:

• Fatigue: Many people experience fatigue or weakness during treatment.
• Hypertension (High Blood Pressure): Regorafenib can lead to an increase in blood pressure. Blood pressure should be regularly monitored during treatment.
• Hand-Foot Skin Reaction: This is a common side effect characterized by redness, swelling, and/or pain on the palms of the hands and soles of the feet.
• Diarrhea: Gastrointestinal symptoms, including diarrhea, can occur. It’s important to stay hydrated, and anti-diarrheal medications may be recommended.
• Nausea and Vomiting: Some individuals may experience nausea and vomiting.
• Loss of Appetite: A decrease in appetite can occur.
• Abdominal Pain: Pain or discomfort in the abdominal area may be reported.
• Liver Function Abnormalities: Regorafenib may affect liver function, leading to increased liver enzymes. Regular monitoring is usually required.
• Infections: There may be an increased risk of infections, and symptoms should be promptly reported to healthcare providers.
• Hoarseness or Voice Changes: Some people may experience changes in their voice.
• Bleeding: Regorafenib can increase the risk of bleeding, and individuals with a history of bleeding disorders or those taking anticoagulant medications should be closely monitored.
• Cardiac Events: Some patients may experience cardiovascular issues, such as myocardial infarction (heart attack) or ischemia.
• Impaired Wound Healing: Regorafenib may slow down the healing process, so caution is advised before and after surgical procedures.

It’s crucial for individuals taking regorafenib to be closely monitored by their healthcare team. They should promptly report any new or worsening symptoms, and regular check-ups and laboratory tests are typically part of the monitoring process. Additionally, patients should inform their healthcare provider about all medications and supplements they are taking, as drug interactions can occur.

This list is not exhaustive, and other side effects may occur. Always consult with a healthcare professional for personalized information based on your health status and individual response to the medication.

What should I know about storage and disposal of this medication?

Storage and Disposal of Regorafenib:

• Storage:
  • Store regorafenib at room temperature, away from excessive heat and moisture.
  • Keep it in its original packaging or container.
  • Store it out of reach of children and pets.
• Disposal:
  • Follow local regulations or guidelines for the proper disposal of medications.
  • Do not flush regorafenib down the toilet or pour it down the drain unless instructed to do so.
  • Consult with your healthcare provider or pharmacist for guidance on the safe disposal of unused or expired medications.

In case of emergency/overdose

In case of an overdose or emergency, it’s important to seek immediate medical attention. Contact your local poison control center or emergency room. The symptoms of an overdose can vary, and medical professionals will provide appropriate treatment based on the situation.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Take regorafenib exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking it without consulting your healthcare team.
• Regular Monitoring: Expect regular check-ups and laboratory tests to monitor the effects of regorafenib and to check for any potential side effects.
• Inform Healthcare Providers: Keep your healthcare provider informed about all medications you are taking, including prescription drugs, over-the-counter medications, and supplements.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of regorafenib with your healthcare provider.
• Avoid Grapefruit Products: Grapefruit and grapefruit juice may interact with regorafenib. Avoid consuming these products during treatment unless advised otherwise by your healthcare provider.
• Report Side Effects: Report any new or worsening symptoms, side effects, or concerns to your healthcare provider promptly.
• Dietary Considerations: Maintain a balanced and nutritious diet. If you have specific dietary concerns, consult your healthcare provider or a registered dietitian.
• Stay Hydrated: Adequate hydration is important, especially if you experience diarrhea or other gastrointestinal symptoms.
• Appointment Attendance: Keep scheduled appointments with your healthcare provider for monitoring and follow-up.
• Drug Interactions: Be aware of potential drug interactions. Inform healthcare providers of all medications and supplements you are taking.

Always consult with your healthcare provider or pharmacist for personalized information and guidance based on your specific health situation. This information is a general guide and may not cover all individual cases or circumstances.