Why is this medication prescribed?

Reblozyl (luspatercept-aamt) is a prescription medication used for the treatment of anemia in adult patients with beta-thalassemia who require regular blood transfusions. Beta-thalassemia is a genetic disorder that affects hemoglobin production, leading to a shortage of red blood cells and causing anemia.

Luspatercept-aamt, the active ingredient in Reblozyl, works by binding to specific proteins involved in the regulation of red blood cell production, ultimately promoting the development and maturation of red blood cells.

How should this medicine be used?

Here are general guidelines on how Reblozyl is typically used, but it’s crucial to follow your healthcare provider’s instructions and dosing recommendations:

• Administration: Reblozyl is usually administered by subcutaneous injection (under the skin) by a healthcare professional.
• Dosage: The dosage of Reblozyl can vary based on individual patient factors, including weight and response to treatment. Your healthcare provider will determine the appropriate dosage for you.
• Frequency: The frequency of Reblozyl injections will depend on your specific treatment plan. Your healthcare provider will establish a dosing schedule tailored to your needs.
• Monitoring: Your healthcare provider may monitor your response to Reblozyl through blood tests to assess changes in hemoglobin levels and adjust the dosage if needed.
• Compliance: It’s essential to follow your healthcare provider’s instructions carefully and attend all scheduled appointments. Do not adjust the dosage or stop the medication without consulting your healthcare provider.
• Side Effects: Like any medication, Reblozyl may cause side effects. Common side effects include headache, bone pain, fatigue, cough, and abdominal pain. Inform your healthcare provider if you experience any unusual or severe side effects.

It’s important to have open communication with your healthcare provider regarding any questions or concerns you may have about Reblozyl. They can provide personalized guidance based on your specific health condition and needs.

Other uses for this medicine

Reblozyl (luspatercept-aamt) is primarily approved for the treatment of anemia in adult patients with beta-thalassemia who require regular blood transfusions. It is not indicated for other uses. However, new indications or updates to approved uses may have occurred since then, so it’s crucial to consult with a healthcare professional or check the most recent prescribing information for the latest details.

What special precautions should I follow?

Regarding special precautions for Reblozyl, here are some general guidelines. However, it’s important to follow your healthcare provider’s advice and refer to the specific prescribing information for the most accurate and up-to-date information:

• Medical History: Inform your healthcare provider about your complete medical history, including any existing medical conditions or allergies.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Reblozyl with your healthcare provider. It is essential to consider the potential impact on the fetus or nursing infant.
• Drug Interactions: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, as well as herbal supplements. Certain medications may interact with Reblozyl, and dose adjustments may be necessary.
• Allergic Reactions: If you have a history of allergic reactions to luspatercept-aamt or any of the components in Reblozyl, inform your healthcare provider.
• Monitoring: Regular monitoring of your blood counts and overall health may be necessary during treatment with Reblozyl. Follow your healthcare provider’s recommendations for monitoring and follow-up appointments.
• Side Effects: Be aware of potential side effects and report any unusual or severe symptoms to your healthcare provider promptly.
• Administration: Reblozyl is typically administered by subcutaneous injection. It should be administered by a healthcare professional according to the prescribed dosage and schedule.
• Missed Dose: If you miss a dose of Reblozyl, contact your healthcare provider for guidance. It’s important to adhere to the prescribed dosing schedule.

Always consult with your healthcare provider or pharmacist for personalized advice and information based on your specific health status and any updates to the prescribing information for Reblozyl. They can provide guidance on potential precautions and address any concerns you may have.

What special dietary instructions should I follow?

There were no specific dietary restrictions mentioned for Reblozyl. However, it’s essential to follow your healthcare provider’s advice regarding your overall diet, especially if you have any specific dietary restrictions or concerns related to your medical condition.

What should I do if I forget a dose?

If you forget to take a dose of Reblozyl, it’s important to contact your healthcare provider for guidance. They will provide instructions on whether to take the missed dose or adjust your dosing schedule. Do not double the dose to make up for a missed one without consulting your healthcare provider.

What side effects can this medication cause?

Reblozyl (luspatercept-aamt) can cause various side effects, and it’s important to be aware of them and promptly inform your healthcare provider if you experience any unusual or severe symptoms. Keep in mind that individual responses to medications can vary, and not everyone will experience the same side effects. Here are some common side effects associated with Reblozyl:

• Headache
• Bone pain
• Fatigue
• Cough
• Abdominal pain

These side effects are not exhaustive, and other side effects may occur. In addition to the more common side effects, there can be more serious side effects or allergic reactions. Seek medical attention immediately if you experience any of the following:

• Signs of an allergic reaction: This can include rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing.
• Signs of blood clotting: Reblozyl may increase the risk of blood clots. Seek medical attention if you experience symptoms such as sudden pain, swelling, warmth, redness, or discoloration in the limbs.
• Hypertension (high blood pressure): Inform your healthcare provider if you experience severe headaches, vision changes, chest pain, or shortness of breath, as these could be signs of high blood pressure.
• Worsening anemia: If you notice an increase in fatigue, weakness, or pallor, inform your healthcare provider.

It’s important to note that this is not a comprehensive list of side effects, and you should consult the prescribing information for Reblozyl or talk to your healthcare provider for the most up-to-date and detailed information. Your healthcare provider can help assess the risks and benefits of Reblozyl based on your individual health status and provide guidance on managing potential side effects. If you experience any unexpected or severe side effects, contact your healthcare provider promptly.

What should I know about storage and disposal of this medication?

Storage and Disposal of Reblozyl:

Storage:

• Refrigeration: Reblozyl should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C).
• Protect from Light: Keep the Reblozyl vials in their original carton to protect them from light.
• Do Not Freeze: Do not freeze Reblozyl. Freezing can damage the medication.
• Expiration Date: Check the expiration date on the packaging, and do not use the medication if it has expired.
• Keep Out of Reach of Children: Store Reblozyl out of the reach of children and pets.

Disposal:

• Unused or Expired Medication: Dispose of any unused or expired Reblozyl according to your healthcare provider’s instructions or local regulations. Do not keep medications that are no longer needed.
• Community Guidelines: Follow local guidelines for the proper disposal of medications. Some areas provide specific instructions or take-back programs for safe disposal.

In case of emergency/overdose

In case of an emergency or suspected overdose, contact your local poison control center (1-800-222-1222 in the United States) or seek emergency medical attention immediately. Provide the healthcare professionals with as much information as possible, including the medication name (Reblozyl), dosage, and any other relevant details.

What other information should I know?

• Regular Follow-Up: Attend all scheduled appointments with your healthcare provider for regular monitoring and follow-up assessments.
• Lab Tests: Your healthcare provider may order regular blood tests to monitor your response to Reblozyl and assess its effectiveness.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care about your use of Reblozyl, including dentists and other specialists.
• Pregnancy/Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Reblozyl with your healthcare provider.
• Interactions: Inform your healthcare provider about all medications, supplements, or herbal products you are taking to avoid potential interactions.

Always consult with your healthcare provider or pharmacist for the most accurate and up-to-date information on storage, disposal, and other important considerations related to Reblozyl. They can provide personalized guidance based on your individual health status and needs.