Why is this medication prescribed?

Aducanumab-avwa, is prescribed to treat Alzheimer’s disease. It is specifically indicated for patients with early-stage Alzheimer’s, such as those with mild cognitive impairment or mild dementia, who have amyloid-beta plaques in their brains. The presence of these plaques is a hallmark of Alzheimer’s disease, and Aducanumab-avwa works by reducing these amyloid plaques. Aducanumab-avwa is a monoclonal antibody that targets and helps remove amyloid-beta plaques from the brain.

How should this medicine be used?

Aducanumab-avwa is administered as an intravenous (IV) infusion. Here are the key points regarding its use:

• Administration Schedule: The medication is given once every four weeks. The infusion typically takes about one hour.
• Dosage: The treatment begins with a lower dose, which is gradually increased over time to minimize potential side effects, such as amyloid-related imaging abnormalities (ARIA), which are common with this medication.
• Monitoring: Patients will undergo regular monitoring, including MRI scans, to check for any potential side effects like ARIA, which can include brain swelling or small areas of bleeding in the brain. The patient’s cognitive function and overall health will also be monitored throughout the treatment.
• Healthcare Provider Involvement: Aducanumab-avwa must be administered under the supervision of a healthcare professional experienced in the management of Alzheimer’s disease and the use of this type of medication.

Due to the risks associated with its use, including ARIA, it’s crucial for patients and their caregivers to discuss the potential benefits and risks of Aducanumab-avwa with their healthcare provider. The decision to start treatment should be based on a thorough evaluation, including diagnostic imaging to confirm the presence of amyloid plaques in the brain.

Aducanumab-avwa’s use should be part of a comprehensive treatment plan for Alzheimer’s disease, which may include other medications, lifestyle changes, and supportive care.

Other uses for this medicine

Currently, Aducanumab-avwa is approved specifically for treating Alzheimer’s disease, focusing on reducing amyloid-beta plaques in the brain. There are no widely recognized off-label uses for Aducanumab-avwa, and its use is limited to its approved indication.

What special precautions should I follow?

Before receiving Aducanumab-avwa injection, there are several precautions you should follow:

• MRI Monitoring: Patients should undergo a brain MRI before starting treatment and periodically during treatment to monitor for amyloid-related imaging abnormalities (ARIA), which can include brain swelling or microhemorrhages.
• Allergic Reactions: Inform your healthcare provider if you have any history of allergic reactions to medications, particularly to other monoclonal antibodies.
• Medical History: Share your full medical history with your doctor, especially if you have a history of stroke, brain hemorrhage, or other neurological conditions.
• Pregnancy and Breastfeeding: Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the effects of Aducanumab-avwa on pregnancy and lactation are not well studied.
• Potential Side Effects: Be aware of possible side effects, including headaches, dizziness, confusion, nausea, and ARIA. Seek immediate medical attention if you experience severe side effects.
• Regular Monitoring: Regular follow-up appointments with your healthcare provider are essential to monitor the drug’s effectiveness and any potential adverse effects.
• Use Caution with Blood Thinners: If you are on blood thinners, inform your doctor, as the combination may increase the risk of bleeding complications.

Always follow the healthcare provider’s instructions and report any unusual symptoms or concerns during the treatment with Aducanumab-avwa.

What special dietary instructions should I follow?

• No Specific Dietary Restrictions: There are no specific dietary restrictions associated with Aducanumab-avwa. However, maintaining a balanced and healthy diet is generally recommended for overall health, especially for individuals with Alzheimer’s disease.
• Hydration: Staying well-hydrated is important, particularly if you experience side effects like nausea or headaches.

What should I do if I forget a dose?

• Contact Your Healthcare Provider: If you miss a dose, call your healthcare provider as soon as you remember. They will advise you on when to reschedule your infusion.
• Do Not Double the Dose: Do not attempt to make up for a missed dose by doubling the next one. Always follow your healthcare provider’s instructions regarding missed doses.

What side effects can this medication cause?

As mentioned earlier, the side effects of Aducanumab-avwa can include:

• Common Side Effects: Amyloid-Related Imaging Abnormalities (ARIA), headache, confusion, falls, dizziness.
• Less Common or Severe Side Effects: Nausea, visual disturbances, allergic reactions.
• Serious: Severe ARIA, severe allergic reactions, increased risk of stroke or bleeding.

It’s crucial to monitor for these side effects and report any symptoms to your healthcare provider.

What should I know about storage and disposal of this medication?

Storage and Disposal of Adstiladrin:

Storage:

• Healthcare Facility Storage: Aducanumab-avwa Injection is typically stored and handled by healthcare professionals in a clinical setting. It is stored in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F) and should not be frozen.
• Before Administration: The solution should be protected from light and should not be shaken. It is usually prepared just before administration, and any unused portion of the medication should be discarded according to standard medical guidelines.

Disposal:

• Healthcare Professionals: Since Aducanumab-avwa is administered in a healthcare setting, the disposal of any unused medication or used medical supplies will be managed by healthcare professionals according to medical waste disposal regulations.

In case of emergency/overdose

• If an overdose is suspected, it is critical to get emergency medical help right away. An overdose is most likely to occur in a healthcare setting, and medical staff would respond immediately to manage the situation.
• Overdose symptoms could potentially include an increased risk of amyloid-related imaging abnormalities (ARIA), such as severe headaches, confusion, nausea, dizziness, or visual disturbances. In severe cases, ARIA could lead to more serious complications like brain swelling or small brain bleeds.
• The treatment for an overdose would involve supportive care and monitoring in a medical setting. This could include additional imaging studies, such as MRI scans, to assess any effects on the brain, and symptomatic treatment based on the specific symptoms experienced.

What other information should I know?

• Medical Identification: Consider carrying a medical ID card or bracelet that notes you are receiving Aducanumab-avwa, especially in case of emergency situations.
• Regular Monitoring: Keep all scheduled appointments for infusions, MRIs, and follow-up visits to ensure the treatment is effective and to monitor for side effects.
• Inform Healthcare Providers: Always inform any healthcare provider you see that you are being treated with Aducanumab-avwa, as this can influence other medical decisions or treatments.
• Lifestyle Considerations: Continue to follow any recommendations regarding diet, exercise, and mental activities that your healthcare provider suggests to manage Alzheimer’s disease.
• Support Systems: Consider involving family members or caregivers in your treatment plan, as they can help monitor your condition and assist with appointments.
• Patient Assistance Programs: If cost is a concern, ask your healthcare provider or the pharmaceutical company about patient assistance programs that may help with the cost of the medication.

Always consult your healthcare provider for specific advice tailored to your situation.