Why is this medication prescribed?

Adakveo (crizanlizumab-tmca) is a medication used to help manage sickle cell disease. It works by targeting and blocking a specific protein that contributes to the blood cells’ tendency to clump together and cause blockages in blood vessels. This can help reduce the frequency of vaso-occlusive crises, which are painful episodes caused by these blockages. Essentially, it helps in reducing the pain and complications associated with sickle cell disease.

How should this medicine be used?

Adakveo (crizanlizumab-tmca) is administered as an injection, usually given into a vein (intravenously). Here’s a general overview of how it’s used:

• Dosage and Schedule: The typical initial dose is 5 mg/kg, administered as an intravenous infusion over 30 minutes. After the initial dose, it’s usually given every 4 weeks.
• Preparation and Administration: The medication is prepared and administered by a healthcare professional. It requires careful handling and preparation to ensure its effectiveness and safety.
• Monitoring: During and after the infusion, the patient is monitored for any potential side effects or reactions.
• Follow-Up: Regular follow-up appointments are necessary to assess the medication’s effectiveness and to adjust the treatment plan as needed.

Always follow the specific instructions provided by your healthcare provider or the medication’s prescribing information for the most accurate guidance tailored to your situation.

Other uses for this medicine

Adakveo (crizanlizumab-tmca) is primarily used for managing sickle cell disease, particularly for reducing the frequency of vaso-occlusive crises. Currently, its use is focused on this indication, and there are no widely recognized off-label uses.

What special precautions should I follow?

Special Precautions:

• Allergies: Inform your healthcare provider if you have any allergies to crizanlizumab or other medications.
• Medical History: Share your complete medical history with your healthcare provider, especially if you have a history of bleeding disorders or other significant health issues.
• Infections: Crizanlizumab may affect your immune system. Inform your provider if you have any signs of infection or if you’re prone to infections.
• Pregnancy and Breastfeeding: If you are pregnant, plan to become pregnant, or are breastfeeding, discuss the potential risks and benefits with your healthcare provider.
• Monitoring: Regular monitoring is necessary to check for any adverse effects or complications during treatment.
• Interactions: Inform your healthcare provider about all other medications or supplements you are taking to avoid potential interactions.

Always follow the advice of your healthcare provider and read the medication guide provided with your prescription for the most accurate and personalized information.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Adakveo. However, maintaining a balanced diet and staying hydrated is generally beneficial for overall health, especially when managing a chronic condition like sickle cell disease. Always consult with your healthcare provider or a nutritionist for personalized advice.

What should I do if I forget a dose?

• Contact Healthcare Provider: If you miss a dose, contact your healthcare provider for instructions. They can provide guidance on whether to reschedule the missed dose or continue with your regular schedule.
• Avoid Double Doses: Do not double up on doses to make up for a missed one. This can increase the risk of side effects.
• Keep Track: Use a calendar or reminder system to help keep track of your medication schedule and avoid missed doses.

What side effects can this medication cause?

Adakveo (crizanlizumab-tmca) can cause side effects, although not everyone experiences them. Common and potential side effects include:

• Headache: This is one of the more common side effects experienced by patients.
• Nausea: Some patients may experience nausea or vomiting.
• Fever: Fever can occur, though it may be mild.
• Fatigue: Feeling tired or fatigued can happen with this medication.
• Joint Pain: Some people may experience joint pain.
• Infusion Reactions: Since Adakveo is given intravenously, some patients may experience reactions related to the infusion, such as pain or swelling at the injection site, or more systemic reactions like chills or rash.
• Allergic Reactions: Although rare, allergic reactions such as rash, itching, swelling, or difficulty breathing can occur.
• Infection: Because Adakveo can affect the immune system, there is a potential risk of infections.

It’s important to report any unusual or severe side effects to your healthcare provider immediately. They can help manage side effects and determine whether any changes to your treatment plan are necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Adakveo:

• Storage: Adakveo should be stored in a refrigerator at 2°C to 8°C (36°F to 46°F). It should be kept in its original carton to protect it from light. Do not freeze the medication.
• Handling: Allow Adakveo to come to room temperature before administration. Do not shake or agitate the vial.
• Disposal: Dispose of any unused or expired Adakveo according to local regulations or guidelines provided by your healthcare provider or pharmacist. Do not throw it in the household trash or flush it down the toilet unless instructed to do so.

In case of emergency/overdose

• Emergency: If you experience a severe allergic reaction (such as trouble breathing, swelling of the face or throat, or severe rash), seek immediate medical attention.
• Overdose: In the event of an overdose, contact your healthcare provider or local poison control center immediately. Overdosing on Adakveo may increase the risk of side effects and complications, but specific treatment measures will be guided by a healthcare professional.

What other information should I know?

• Regular Monitoring: Regular follow-up appointments are important to monitor the effectiveness of the medication and adjust the treatment plan as needed.
• Medication Records: Keep a record of your medication schedule and any side effects you experience. This information can be useful for your healthcare provider.
• Emergency Contacts: Have contact information for your healthcare provider or medical facility readily available in case of emergencies.
• Patient Support: If you have any questions or concerns about your treatment or the medication, don’t hesitate to reach out to your healthcare provider or pharmacist for guidance and support.

Always follow your healthcare provider’s guidance for the best outcomes while using Adakveo.