WARNING

Pristiq (generic name: desvenlafaxine) is a medication commonly prescribed to treat major depressive disorder. Like any medication, Pristiq comes with potential risks and side effects. It’s essential to consult with a healthcare professional for personalized advice and to discuss your specific medical history. However, here are some general risks associated with Pristiq:

• Side Effects: Pristiq may cause common side effects such as nausea, dizziness, insomnia, dry mouth, constipation, and sweating. These side effects are usually temporary and may subside as your body adjusts to the medication.
• Serotonin Syndrome: Pristiq can increase serotonin levels, and in rare cases, this may lead to serotonin syndrome. Symptoms include confusion, hallucinations, rapid heartbeat, fever, muscle stiffness, and nausea. Seek immediate medical attention if you experience these symptoms.
• Withdrawal Symptoms: Abruptly stopping Pristiq can lead to withdrawal symptoms, including irritability, nausea, dizziness, and headache. It’s important to taper off the medication under the guidance of a healthcare professional.
• Increased Blood Pressure: Pristiq may lead to an increase in blood pressure. Regular monitoring of blood pressure is recommended, especially in individuals with pre-existing hypertension.
• Hyponatremia: In rare cases, Pristiq may cause low sodium levels in the blood (hyponatremia), which can manifest as symptoms like headache, confusion, seizures, and difficulty concentrating. This condition requires medical attention.
• Risk of Suicidal Thoughts: Antidepressants, including Pristiq, have been associated with an increased risk of suicidal thoughts, especially in young adults. Close monitoring is crucial, especially when starting or adjusting the dosage.
• Interaction with Other Medications: Pristiq may interact with other medications, including monoamine oxidase inhibitors (MAOIs), leading to potentially serious side effects. Inform your healthcare provider about all medications you are taking.
• Pregnancy and Breastfeeding: The safety of Pristiq during pregnancy and breastfeeding is not well-established. Consult with your healthcare provider to weigh the potential risks and benefits.

It’s important to note that the benefits of Pristiq in treating depression may outweigh the risks for many individuals. Always follow your healthcare provider’s recommendations, and promptly report any unusual or severe side effects. Never adjust your medication without consulting your healthcare professional.

Why is this medication prescribed?

Pristiq (generic name: desvenlafaxine) is commonly prescribed to treat major depressive disorder (MDD), a condition characterized by persistent feelings of sadness and a lack of interest or pleasure in daily activities. It belongs to a class of medications known as serotonin-norepinephrine reuptake inhibitors (SNRIs). Pristiq works by increasing the levels of serotonin and norepinephrine in the brain, which are neurotransmitters associated with mood regulation.

How should this medicine be used?

Here are some key points on how Pristiq is typically used:

• Dosage: The usual starting dose for Pristiq is 50 milligrams (mg) once daily, taken with or without food. The dosage may be adjusted based on individual response and tolerability, with a maximum recommended dose of 100 mg per day.
• Administration: Pristiq is usually taken as a single daily dose, preferably at the same time each day. The tablet should be swallowed whole with water and should not be crushed, chewed, or divided.
• Tapering: When discontinuing Pristiq, it’s important to taper the dose gradually under the supervision of a healthcare professional to minimize the risk of withdrawal symptoms.
• Monitoring: Regular monitoring by a healthcare provider is important, especially during the initial weeks of treatment. This allows for assessment of the medication’s effectiveness and the occurrence of any side effects.
• Response Time: It may take several weeks for Pristiq to exert its full therapeutic effect. Patients are advised to continue taking the medication as prescribed, even if they do not notice immediate improvement in their symptoms.
• Avoiding Alcohol: It is advisable to limit or avoid alcohol consumption while taking Pristiq, as alcohol can enhance certain side effects of the medication.
• Interactions: Inform your healthcare provider about all medications, including over-the-counter drugs and herbal supplements, that you are taking. Pristiq may interact with other medications, and adjustments may be necessary.
• Special Populations: Pristiq’s safety during pregnancy and breastfeeding is not well-established, so it’s essential to discuss potential risks and benefits with a healthcare provider if you are pregnant or nursing.

Always follow the specific instructions provided by your healthcare professional and the medication guide accompanying Pristiq. Do not adjust your dosage or stop taking the medication without consulting your healthcare provider, as sudden changes may lead to withdrawal symptoms or a recurrence of depressive symptoms. If you experience any side effects or have concerns about your medication, promptly discuss them with your healthcare provider.

Other uses for this medicine

Pristiq (desvenlafaxine) is primarily prescribed for the treatment of major depressive disorder (MDD). However, healthcare providers may also consider it for other conditions if they believe the potential benefits outweigh the risks. Some off-label uses may include generalized anxiety disorder and certain types of chronic pain conditions. Nevertheless, the primary focus of Pristiq remains the treatment of major depressive disorder.

What special precautions should I follow?

When using Pristiq, it’s important to follow specific precautions to ensure its safe and effective use. Here are some key precautions:

• Allergies: Inform your healthcare provider about any allergies you have, especially if you are allergic to desvenlafaxine or venlafaxine (Effexor), as Pristiq is closely related to Effexor.
• Medical History: Provide a detailed medical history to your healthcare provider, including any history of heart problems, high blood pressure, liver disease, kidney disease, seizures, bipolar disorder, or bleeding disorders.
• Suicidal Thoughts: Antidepressants, including Pristiq, may increase the risk of suicidal thoughts, especially in the early stages of treatment. Monitor for any changes in mood or behavior and report them to your healthcare provider immediately.
• Medication Interactions: Inform your healthcare provider about all medications, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements, that you are taking. Pristiq may interact with other medications, and adjustments may be necessary.
• Serotonin Syndrome: Be cautious about the potential for serotonin syndrome, a serious condition that can occur when there is an excess of serotonin in the body. Symptoms include confusion, hallucinations, rapid heartbeat, fever, muscle stiffness, and nausea. Seek immediate medical attention if you experience these symptoms.
• Pregnancy and Breastfeeding: The safety of Pristiq during pregnancy and breastfeeding is not well-established. Consult with your healthcare provider to weigh the potential risks and benefits if you are pregnant or nursing.
• Alcohol and Other Substances: Limit or avoid alcohol consumption while taking Pristiq, as alcohol can enhance certain side effects of the medication. Also, be cautious with substances that can affect the central nervous system.
• Regular Monitoring: Regularly attend follow-up appointments with your healthcare provider to monitor the medication’s effectiveness and assess any potential side effects.

It’s crucial to take Pristiq exactly as prescribed by your healthcare provider. Do not adjust the dosage or discontinue the medication without consulting them, as sudden changes may lead to withdrawal symptoms or a recurrence of depressive symptoms. If you have any concerns or experience side effects, promptly discuss them with your healthcare professional.

What special dietary instructions should I follow?

There are no specific dietary restrictions for Pristiq. However, maintaining a healthy and balanced diet is generally beneficial for overall well-being. Avoid excessive consumption of alcohol, as it may enhance certain side effects of the medication.

What should I do if I forget a dose?

If you miss a dose of Pristiq, take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Pristiq (desvenlafaxine) may cause side effects, and it’s important to be aware of them. Keep in mind that not everyone will experience these side effects, and their severity can vary. Common side effects include:

• Nausea: A feeling of discomfort or queasiness in the stomach.
• Dizziness: A sensation of lightheadedness or unsteadiness.
• Insomnia: Difficulty falling or staying asleep.
• Dry Mouth: A reduction in saliva production, leading to a dry sensation in the mouth.
• Constipation: Difficulty passing stools or infrequent bowel movements.
• Sweating: Increased sweating, often during sleep.
• Loss of Appetite: A decrease in the desire to eat.
• Fatigue: Feeling tired or lacking energy.
• Increased Blood Pressure: Pristiq can, in some cases, lead to an increase in blood pressure.
• Abnormal Dreams: Unusual or vivid dreams during sleep.

It’s important to note that while many people tolerate Pristiq well, some individuals may experience more serious side effects. These can include:

• Serotonin Syndrome: Though rare, an excess of serotonin in the body can lead to symptoms such as confusion, hallucinations, rapid heartbeat, fever, muscle stiffness, and nausea. Seek immediate medical attention if you experience these symptoms.
• Allergic Reactions: Some people may be allergic to Pristiq, and signs of an allergic reaction can include rash, itching, swelling, severe dizziness, or difficulty breathing. Seek emergency medical attention if you experience these symptoms.
• Withdrawal Symptoms: Abruptly stopping Pristiq may lead to withdrawal symptoms, such as irritability, nausea, dizziness, headache, and fatigue. Tapering the medication under the guidance of a healthcare professional can help minimize these effects.
• Hyponatremia: In rare cases, Pristiq may cause low levels of sodium in the blood, leading to symptoms such as headache, confusion, seizures, and difficulty concentrating.

If you experience any unusual or severe side effects, it’s important to contact your healthcare provider promptly. They can provide guidance on whether adjustments to your treatment plan are necessary. Additionally, discuss any concerns or side effects during regular follow-up appointments.

What should I know about storage and disposal of this medication?

Storage and Disposal of Pristiq:

Storage:

• Keep Pristiq in its original packaging or container.
• Store it at room temperature, away from moisture and heat.
• Do not store Pristiq in the bathroom.
  Disposal:
• Follow specific disposal instructions provided by your healthcare provider or pharmacist.
• Do not flush medications down the toilet unless instructed to do so.
• Dispose of expired or unused medication properly, following local regulations or guidelines.

In case of emergency/overdose

In case of emergency or overdose, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention. Symptoms of overdose may include:

• Extreme drowsiness
• Seizures
• Fast or irregular heartbeat
• Unconsciousness
• Vomiting

What other information should I know?

• Regular Monitoring: Attend follow-up appointments with your healthcare provider for regular monitoring of your response to Pristiq and any potential side effects.
• Avoid Alcohol: Limit or avoid alcohol while taking Pristiq, as it can enhance certain side effects of the medication.
• Inform Healthcare Providers: Inform all healthcare providers, including dentists and surgeons, about your use of Pristiq. It’s important to disclose this information before any medical or dental procedures.
• Interactions with Other Medications: Inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.
• Pregnancy and Breastfeeding: Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Pristiq during pregnancy and breastfeeding is not well-established.
• Driving and Operating Machinery: Pristiq may cause dizziness, so use caution when driving or operating machinery until you know how the medication affects you.
• Consistent Use: Take Pristiq as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your healthcare provider.

Always consult with your healthcare provider or pharmacist if you have specific questions or concerns about the storage, disposal, or usage of Pristiq. They can provide personalized guidance based on your individual health status and needs.