WARNING

Plecanatide is a medication primarily used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation. As with any medication, there are potential risks and side effects associated with its use. It’s important to note that the information provided here is general, and individual experiences may vary.

Common side effects of plecanatide may include diarrhea, abdominal pain, flatulence, and headache. Diarrhea can be severe in some cases and may lead to dehydration. It’s crucial to stay hydrated and contact a healthcare professional if severe diarrhea persists.

Some individuals may be more sensitive to plecanatide, and certain pre-existing conditions may increase the risk of adverse effects. People with a history of bowel obstructions or known or suspected gastrointestinal (GI) perforations should avoid plecanatide. Additionally, individuals with kidney problems or those taking medications that affect renal function may have an increased risk of dehydration.

As with any medication, it’s essential to discuss your medical history and any existing health conditions with your healthcare provider before starting plecanatide. They can provide personalized advice based on your specific situation and help monitor for potential risks and side effects during treatment. If you experience any unusual or severe symptoms while taking plecanatide, contact your healthcare provider promptly.

Why is this medication prescribed?

Plecanatide is prescribed primarily for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. It belongs to a class of medications known as guanylate cyclase-C agonists. Plecanatide works by increasing fluid secretion in the intestines, which helps to soften stool and facilitate bowel movements.

How should this medicine be used?

Here are general guidelines on how plecanatide is typically used:

• Dosage: The usual recommended dosage for plecanatide is once daily, orally, without regard to meals.
• Chronic Idiopathic Constipation (CIC): The recommended dose for CIC is 3 mg taken orally once daily.
• Irritable Bowel Syndrome with Constipation (IBS-C): The recommended dose for IBS-C is 3 mg taken orally once daily.
• Administration: Plecanatide should be taken with a glass of water, and it can be taken with or without food.
• Monitoring: It is important for healthcare providers to monitor the patient’s response to the medication and adjust the dosage if necessary.

It’s crucial for individuals to follow their healthcare provider’s instructions and take plecanatide exactly as prescribed. If a dose is missed, it should be taken as soon as remembered, unless it is almost time for the next scheduled dose. However, a double dose should not be taken to make up for a missed one.

As with any medication, it’s important for individuals to discuss their medical history, current medications, and any concerns or potential side effects with their healthcare provider before starting plecanatide. If there are any unexpected or severe side effects, it’s crucial to contact a healthcare professional promptly.

Other uses for this medicine

Plecanatide is primarily approved for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). As of last knowledge update, it is not indicated for other uses. Always consult with a healthcare professional for the most up-to-date and accurate information.

What special precautions should I follow?

When using plecanatide, it’s essential to take certain precautions:

• Medical History: Inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, or gastrointestinal issues. This information helps them assess the suitability of plecanatide for you.
• Medication Interactions: Discuss all the medications, supplements, and over-the-counter drugs you are currently taking with your healthcare provider. Certain medications may interact with plecanatide, affecting its efficacy or increasing the risk of side effects.
• Bowel Disorders: If you have a history of bowel obstructions or gastrointestinal perforations, it’s important to avoid plecanatide. This medication may not be suitable for individuals with severe or pre-existing bowel disorders.
• Dehydration Risk: Severe diarrhea is a potential side effect of plecanatide, which could lead to dehydration. It’s crucial to stay adequately hydrated while taking the medication. If you experience persistent diarrhea or signs of dehydration (such as dizziness or reduced urine output), contact your healthcare provider.
• Renal Impairment: Individuals with kidney problems or those taking medications affecting renal function may be at an increased risk of dehydration. Plecanatide should be used with caution in such cases.
• Pregnancy and Breastfeeding: The safety of plecanatide during pregnancy and breastfeeding is not well established. Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before using plecanatide.

Always follow your healthcare provider’s recommendations and guidelines for taking plecanatide. If you experience any unexpected or severe side effects, contact your healthcare professional promptly. Regular follow-up appointments will allow your healthcare provider to monitor your response to the medication and make any necessary adjustments to the treatment plan.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Plecanatide. However, maintaining a healthy and well-balanced diet can contribute to overall digestive health. If you have any specific concerns about your diet or nutritional intake, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget a dose of Plecanatide:

• Take it as soon as you remember: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not double up on doses: Do not take a double dose to make up for a missed one. Taking more than the prescribed amount could increase the risk of side effects.

What side effects can this medication cause?

Plecanatide, like any medication, can cause side effects. Not everyone will experience these side effects, and some individuals may have different reactions. Common side effects of Plecanatide include:

• Diarrhea: Diarrhea is one of the most commonly reported side effects. It may be mild to moderate in severity. If diarrhea persists or becomes severe, contact your healthcare provider.
• Abdominal pain: Some individuals may experience abdominal discomfort or pain while taking Plecanatide.
• Flatulence (gas): Increased gas production in the digestive tract is a reported side effect.
• Headache: Headaches have been reported by some individuals using Plecanatide.

It’s important to note that while these side effects are common, they are not experienced by everyone, and many people tolerate the medication well. Additionally, the severity of side effects can vary among individuals.

Serious side effects are rare but can occur. If you experience any of the following, contact your healthcare provider immediately:

• Severe or persistent diarrhea: Prolonged or severe diarrhea can lead to dehydration and electrolyte imbalance.
• Signs of dehydration: Dizziness, lightheadedness, decreased urine output, or other symptoms of dehydration should be addressed promptly.
• Allergic reactions: While rare, allergic reactions may occur. Seek medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s crucial to follow your healthcare provider’s instructions, report any side effects promptly, and attend scheduled follow-up appointments. Your healthcare provider can assess the overall benefits of the medication and help manage any side effects that may arise during treatment. If you have concerns about Plecanatide or experience unexpected symptoms, consult with your healthcare provider for personalized guidance.

What should I know about storage and disposal of this medication?

Here are important considerations regarding the storage and disposal information about Plecanatide:

Storage:

• Store Plecanatide at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep it in its original container, away from moisture and light.
• Do not store Plecanatide in the bathroom, as the moisture can affect its stability.

Disposal:

• Dispose of unused or expired medication in accordance with local regulations.
• Do not flush Plecanatide down the toilet or pour it into a drain unless specifically instructed to do so.
• Consult your healthcare provider or pharmacist for guidance on the proper disposal of Plecanatide.

In case of emergency/overdose

• In case of an overdose or emergency, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention.
• Symptoms of an overdose may include severe diarrhea, dehydration, or other unusual symptoms. Prompt medical attention is essential.

What other information should I know?

• Follow your healthcare provider’s instructions regarding the dosage and schedule for taking Plecanatide.
• Inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are taking to avoid potential interactions.
• Attend regular follow-up appointments with your healthcare provider to monitor your response to Plecanatide and address any concerns or side effects.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Plecanatide with your healthcare provider.
• Report any unusual or severe side effects to your healthcare provider promptly.
• Keep a list of all your medications, including Plecanatide, and share it with your healthcare provider or pharmacist.

Always follow your healthcare provider’s advice and read the medication guide provided with Plecanatide for specific information. If you have any questions or concerns, consult your healthcare provider or pharmacist for personalized guidance.