Why is this medication prescribed?

Pemigatinib is a medication used for the treatment of certain types of cancer, specifically cholangiocarcinoma. Cholangiocarcinoma is a type of cancer that originates in the bile ducts, which are tubes that carry bile from the liver to the small intestine. Pemigatinib is a tyrosine kinase inhibitor that works by blocking specific proteins involved in the growth of cancer cells.

How should this medicine be used?

Pemigatinib is a prescription medication, and its use should be directed by a qualified healthcare professional. The information provided here is a general guideline, and individual dosing instructions may vary based on the specific medical condition, overall health, and other factors of the patient. Always follow the instructions given by your healthcare provider. Here are general guidelines for the use of pemigatinib:

• Dosage: The recommended dosage of pemigatinib can vary. Typically, it is taken orally in the form of tablets.
• Administration: Pemigatinib tablets are usually swallowed whole with water. They should not be crushed, broken, or chewed.
• Timing: The medication may be taken with or without food. Follow your healthcare provider’s instructions regarding the timing of doses.
• Missed Dose: If a dose is missed, patients are usually advised to take it as soon as they remember. However, if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule should be resumed.
• Interactions: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, supplements, and herbal products, that you are taking. Pemigatinib may interact with other medications, and your healthcare provider will consider these factors when prescribing.
• Monitoring: Regular medical check-ups and monitoring are typically required while taking pemigatinib. Your healthcare provider will assess your response to the medication and monitor for potential side effects.
• Side Effects: Be aware of potential side effects and contact your healthcare provider if you experience any unusual or severe symptoms.
• Precautions: Inform your healthcare provider about your medical history, including any allergies, liver problems, or other conditions, before starting pemigatinib.

It’s important to note that the information provided here is a general overview, and specific instructions may vary. Always consult with your healthcare provider for personalized advice and guidance based on your individual health status and medical history. If you have any concerns or questions about pemigatinib, discuss them with your healthcare team for the most accurate and up-to-date information.

Other uses for this medicine

Pemigatinib (brand name: Pemazyre) is primarily used for the treatment of cholangiocarcinoma, a type of cancer that affects the bile ducts. It is a targeted therapy that inhibits certain proteins involved in cancer cell growth. However, it’s essential to note that medications can have off-label uses or new indications that may have emerged since last update. Always follow your healthcare provider’s instructions and consult them for the most current information.

What special precautions should I follow?

Regarding special precautions for pemigatinib, it’s crucial to consider the following:

• Medical History: Inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, or previous reactions to medications.
• Medication Interactions: Provide a list of all medications, supplements, and herbal products you are taking. Pemigatinib may interact with other drugs, and your healthcare provider needs to consider these interactions to ensure your safety.
• Liver Function: Pemigatinib is metabolized by the liver, so individuals with pre-existing liver conditions may require special monitoring. Your healthcare provider may perform regular liver function tests.
• Pregnancy and Breastfeeding: Pemigatinib may harm an unborn baby, so it is important to inform your healthcare provider if you are pregnant or planning to become pregnant. Similarly, breastfeeding should be avoided during treatment with pemigatinib.
• Fertility: Pemigatinib may affect fertility. If you are of reproductive potential, discuss contraception options with your healthcare provider.
• Side Effects: Be aware of potential side effects, including common and severe ones. Common side effects may include fatigue, increased blood phosphate levels, hair loss, and others. Serious side effects can occur, and you should contact your healthcare provider if you experience symptoms such as liver problems, high blood pressure, or severe skin reactions.
• Regular Monitoring: Regular medical check-ups and monitoring of your response to pemigatinib are typically required. Follow your healthcare provider’s recommendations for follow-up appointments and tests.

It’s essential to emphasize that the information provided here is based on general knowledge up to last update. Your healthcare provider will provide you with specific guidelines and precautions based on your individual health status. Always consult with your healthcare team for the most accurate and up-to-date information regarding the use of pemigatinib and any special precautions that may apply to your situation.

What special dietary instructions should I follow?

As of last knowledge update, there were no specific dietary restrictions associated with pemigatinib. However, dietary recommendations may vary based on individual health conditions and considerations. Always follow your healthcare provider’s guidance regarding your diet during treatment.

What should I do if I forget a dose?

If you forget to take a dose of pemigatinib, follow these general guidelines:

• Take It as Soon as Possible: If you remember shortly after the scheduled time, take the missed dose as soon as possible.
• Skip the Missed Dose if Close to the Next Dose: If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
• Do Not Double Up: Do not take a double dose to make up for a missed one. This can increase the risk of side effects.

What side effects can this medication cause?

Pemigatinib, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary. If you are prescribed pemigatinib, your healthcare provider will monitor you for potential side effects and provide guidance on how to manage them. Here are some common and potentially serious side effects associated with pemigatinib:

Common Side Effects:

• Fatigue
• Increased Blood Phosphate Levels
• Hair Loss (Alopecia)
• Nausea
• Diarrhea
• Decreased Appetite
• Constipation
• Stomach Pain or Discomfort
• Changes in Taste

Serious Side Effects:

• Liver Problems: Pemigatinib can cause liver enzyme elevations. Your healthcare provider will monitor your liver function through blood tests.
• High Blood Pressure (Hypertension): Pemigatinib may cause an increase in blood pressure. Regular blood pressure monitoring is essential.
• Serious Skin Reactions: Severe skin reactions, including rash, blistering, and peeling, have been reported. If you experience any skin changes, notify your healthcare provider immediately.
• Eye Problems: Pemigatinib may cause eye problems such as dry eyes or changes in the cornea. Report any changes in vision or eye discomfort.
• Phosphate Imbalance: Pemigatinib can affect phosphate levels in the blood. Your healthcare provider will monitor these levels and may recommend supplements if necessary.
• Gastrointestinal Perforations: In rare cases, pemigatinib may lead to gastrointestinal perforations. Seek immediate medical attention if you experience severe abdominal pain.
• Blood Clot Formation: There may be an increased risk of blood clot formation. Notify your healthcare provider if you experience symptoms such as swelling, pain, or redness in the limbs.
• Pancreatitis: Inflammation of the pancreas may occur. Report symptoms such as persistent abdominal pain, nausea, and vomiting.

It’s essential to promptly communicate any side effects or concerns to your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment plan if necessary.

This list is not exhaustive, and other side effects may occur. Individual responses to medications can vary, so it’s crucial to discuss your specific situation with your healthcare provider. Always follow your healthcare provider’s instructions and attend regular check-ups to monitor for potential side effects during pemigatinib treatment.

What should I know about storage and disposal of this medication?

Storage of Pemigatinib:

• Store as Directed: Keep pemigatinib in its original packaging and store it according to the specific instructions provided by the pharmacist or healthcare provider.
• Room Temperature: Most medications are stored at room temperature, but confirm the exact temperature range for pemigatinib with your healthcare provider.
• Protect from Light and Moisture: Some medications are sensitive to light and moisture. Ensure that pemigatinib is stored in a dry place and protected from direct sunlight.
• Keep Out of Reach of Children and Pets: Store pemigatinib in a location where children and pets cannot access it.

Disposal of Pemigatinib:

• Follow Local Guidelines: Follow local guidelines for the disposal of medications. Some areas have specific instructions for medication disposal to minimize environmental impact.
• Do Not Flush: Do not flush pemigatinib down the toilet unless instructed to do so by local guidelines.
• Drug Take-Back Programs: Check if there are drug take-back programs or community disposal events in your area. These programs provide safe ways to dispose of medications.
• Ask Your Pharmacist: Your pharmacist may provide information on proper disposal methods. If in doubt, consult with them.

In case of emergency/overdose

In case of emergency or overdose, contact your local emergency services (e.g., 911 in the United States) immediately. Additionally:

• Contact Poison Control Center: In the United States, you can contact the Poison Control Center at 1-800-222-1222 for guidance on overdose management.
• Notify Healthcare Provider: Inform your healthcare provider about the overdose as soon as possible.

What other information should I know?

• Regular Follow-ups: Attend regular follow-up appointments with your healthcare provider. These appointments are crucial for monitoring your response to treatment and addressing any concerns.
• Lab Tests: Your healthcare provider may order regular lab tests to monitor your liver function and other parameters. Attend these tests as scheduled.
• Inform Healthcare Providers: Keep all healthcare providers (including dentists and specialists) informed about your pemigatinib treatment. They need to be aware of all medications you are taking.
• Inform About New Medications: Before starting any new medications, supplements, or herbal products, inform your healthcare provider. Some substances may interact with pemigatinib.
• Stay Informed: Stay informed about potential side effects and contact your healthcare provider if you experience any unusual symptoms.

Always follow your healthcare provider’s instructions and seek immediate medical attention for any concerns related to pemigatinib. This information is not exhaustive, and individual circumstances may vary, so consult with your healthcare team for personalized guidance.