Why is this medication prescribed?

Pemazyre (pemigatinib) is a prescription medication used to treat certain types of advanced or metastatic cholangiocarcinoma, a type of cancer that originates in the bile ducts. Specifically, Pemazyre is indicated for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement as detected by an FDA-approved test.

How should this medicine be used?

Here are some key points about the use of Pemazyre:

• Prescription and Testing: Pemazyre is available only with a prescription from a healthcare provider. Before starting Pemazyre treatment, patients should undergo testing to confirm the presence of an FGFR2 fusion or rearrangement.
• Dosage: The recommended dosage of Pemazyre can vary, and it is essential to follow the specific instructions provided by the healthcare provider. Pemazyre is typically taken orally once daily.
• Administration: The medication can be taken with or without food. It is important to swallow the tablets whole and not crush or chew them.
• Monitoring and Adjustments: Patients undergoing Pemazyre treatment will be monitored regularly by their healthcare team. The healthcare provider may adjust the dosage or temporarily interrupt treatment based on individual patient factors, such as side effects or laboratory test results.
• Side Effects: Like any medication, Pemazyre can cause side effects. Common side effects may include hyperphosphatemia (high levels of phosphate in the blood), alopecia (hair loss), fatigue, diarrhea, and nail toxicity. Patients should promptly report any side effects or concerns to their healthcare provider.
• Contraindications and Precautions: Pemazyre may not be suitable for everyone. Healthcare providers will consider individual patient factors, medical history, and potential drug interactions before prescribing Pemazyre. Certain pre-existing conditions or medications may warrant caution or adjustment of the treatment plan.

It is crucial for individuals prescribed Pemazyre to closely follow their healthcare provider’s instructions, attend regular check-ups, and communicate any concerns or changes in their health. Additionally, patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking to avoid potential interactions. As with any cancer treatment, the decision to use Pemazyre should be made in consultation with a qualified healthcare professional who can assess the individual’s specific medical condition and needs.

Other uses for this medicine

Pemazyre (pemigatinib) is primarily indicated for the treatment of advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement. However, it’s important to note that new information and additional indications may have emerged since then.

What special precautions should I follow?

Regarding special precautions for Pemazyre, it’s crucial for patients to follow their healthcare provider’s guidance and instructions. Here are some general precautions and considerations:

• Testing and Indication: Pemazyre is typically prescribed based on the results of an FDA-approved test that confirms the presence of an FGFR2 fusion or rearrangement. Ensure that appropriate testing is conducted before starting treatment.
• Medical History: Inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, or medications you are currently taking. This information will help determine if Pemazyre is suitable for you.
• Pregnancy and Breastfeeding: Pemazyre may cause harm to a developing fetus, so it is essential to inform your healthcare provider if you are pregnant or planning to become pregnant. Use effective contraception during treatment and for a certain period after discontinuation, as advised by your healthcare provider. Breastfeeding is not recommended during Pemazyre treatment and for some time after the last dose.
• Liver Function: Pemazyre may affect liver function. Regular monitoring of liver function tests is typically conducted during treatment. Patients with pre-existing liver conditions may require closer monitoring.
• Phosphate Levels: Pemazyre may cause increased levels of phosphate in the blood (hyperphosphatemia). Monitoring of phosphate levels is important, and adjustments to the treatment plan may be made based on the results.
• Drug Interactions: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, as well as dietary supplements and herbal products, that you are taking. Some medications may interact with Pemazyre.
• Side Effects: Be aware of potential side effects of Pemazyre and promptly report any unusual symptoms or side effects to your healthcare provider. This may include issues such as diarrhea, fatigue, hair loss (alopecia), and nail toxicity.
• Dose Adjustments: Dosage adjustments or temporary interruptions of treatment may be necessary based on individual patient factors, such as side effects or laboratory test results. It’s important to follow your healthcare provider’s recommendations in this regard.

Always consult with your healthcare provider for the most current and personalized information regarding the use of Pemazyre, as well as any specific precautions or considerations based on your individual health status.

What special dietary instructions should I follow?

As of last update, there were no specific dietary restrictions associated with Pemazyre. However, it’s essential to follow your healthcare provider’s advice, as individual cases may vary. If there have been updates or changes in guidelines since last knowledge update, your healthcare provider will provide the most accurate information.

What should I do if I forget a dose?

If you miss a dose of Pemazyre, the general recommendation is to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Pemazyre (pemigatinib) can cause various side effects, and it’s important for individuals taking the medication to be aware of these potential effects. Keep in mind that the severity and occurrence of side effects can vary from person to person. If you are prescribed Pemazyre, your healthcare provider will closely monitor you and address any concerns you may have. Common side effects of Pemazyre may include:

• Hyperphosphatemia: Elevated levels of phosphate in the blood.
• Alopecia (Hair Loss): Hair loss is a common side effect.
• Fatigue: Feeling tired or lacking energy.
• Diarrhea: An increase in bowel movements or loose stools.
• Nail Toxicity: Changes in the nails, such as discoloration or problems with the nail beds.

It’s important to report any side effects or symptoms to your healthcare provider promptly. Additionally, there may be other less common but potentially serious side effects associated with Pemazyre. These can include:

• Liver Problems: Pemazyre may affect liver function, and serious liver problems can occur. Regular monitoring of liver function is typically performed during treatment.
• Eye Problems: Pemazyre may cause changes in the eyes, such as increased tear production and inflammation of the cornea. Report any vision changes or eye problems to your healthcare provider.
• High Blood Phosphate Levels: Pemazyre can lead to increased phosphate levels in the blood, which may require monitoring and management.
• Gastrointestinal Perforations: Rarely, gastrointestinal perforations can occur, which may be serious. Seek medical attention if you experience severe abdominal pain.
• Blood Clotting Disorders: Pemazyre may increase the risk of blood clotting. Inform your healthcare provider if you have a history of blood clotting disorders or if you experience symptoms such as swelling or redness in the legs.

It’s essential to follow your healthcare provider’s instructions, attend regular check-ups, and communicate any concerns or changes in your health. If you are prescribed Pemazyre, your healthcare provider will discuss the potential risks and benefits based on your individual health status.

This information is not exhaustive, and individual responses to medication can vary. Always consult with your healthcare provider for the most up-to-date and personalized information regarding Pemazyre and its potential side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Pemazyre:

• Storage: Store Pemazyre at room temperature away from light and moisture. Follow the specific storage instructions provided by your healthcare provider or pharmacist.
• Keep Away from Children and Pets: Keep Pemazyre out of reach of children and pets. The medication should only be used by the person for whom it was prescribed.
• Do Not Share Medication: Do not share Pemazyre with others, even if they have a similar condition.
• Disposal: Dispose of Pemazyre as instructed by your healthcare provider or pharmacist. Do not flush medications down the toilet unless specifically instructed to do so.

In case of emergency/overdose

• Seek Medical Attention: In the case of an overdose or if you suspect an overdose, seek immediate medical attention or contact a poison control center.
• Symptoms of Overdose: Symptoms of an overdose may include increased severity of side effects such as diarrhea, fatigue, or other adverse reactions.

What other information should I know?

• Regular Monitoring: Your healthcare provider will likely schedule regular check-ups, including blood tests, to monitor your response to Pemazyre and to detect any potential side effects.
• Follow Healthcare Provider’s Instructions: Follow your healthcare provider’s instructions precisely regarding dosages, administration, and any recommended lifestyle or dietary changes.
• Inform Healthcare Provider: Keep your healthcare provider informed about any other medications, supplements, or herbal products you are taking, as they may interact with Pemazyre.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Pemazyre may have potential risks during pregnancy and breastfeeding.
• Vision Changes: Report any changes in vision or eye problems to your healthcare provider.
• Contact Healthcare Provider for Concerns: If you experience any unusual or severe side effects or have concerns about your treatment, contact your healthcare provider promptly.

Always consult your healthcare provider or pharmacist for the most accurate and up-to-date information regarding the storage, disposal, and emergency procedures for Pemazyre. They can provide guidance specific to your individual circumstances and ensure that you have the information needed for safe and effective use of the medication.