WARNING

Parathyroid hormone (PTH) is a naturally occurring hormone in the body that regulates calcium and phosphorus levels. Parathyroid hormone injections, such as teriparatide, are sometimes prescribed to treat osteoporosis. While these injections can be effective, they come with certain risks and side effects. It’s important to note that individual responses to medications can vary, and you should always consult with your healthcare provider for personalized information. Here are some potential risks associated with parathyroid hormone injections:

• Hypercalcemia: Excessive levels of calcium in the blood can occur as a result of parathyroid hormone therapy. This can lead to symptoms such as nausea, vomiting, weakness, and confusion.
• Bone Pain: Some individuals may experience bone pain or joint pain as a side effect of parathyroid hormone injections.
• Orthostatic Hypotension: A sudden drop in blood pressure upon standing, known as orthostatic hypotension, may occur in some individuals using PTH injections.
• Nausea and Vomiting: These gastrointestinal symptoms can occur as side effects of the medication.
• Leg Cramps: Some people may experience leg cramps while on parathyroid hormone therapy.
• Dizziness: Feeling lightheaded or dizzy may occur, especially when standing up quickly.
• Increased Risk of Osteosarcoma: There have been concerns about a potential link between long-term use of teriparatide and an increased risk of osteosarcoma (a type of bone cancer). However, the evidence is not conclusive, and further research is needed to establish a definitive association.

It’s essential to discuss any concerns or potential side effects with your healthcare provider before starting parathyroid hormone injections. They can provide guidance based on your specific health profile and help monitor for any adverse effects during the course of treatment.

Why is this medication prescribed?

Parathyroid hormone (PTH) injections, such as teriparatide, are prescribed for specific medical conditions, primarily the treatment of osteoporosis. Osteoporosis is a condition characterized by the weakening of bones, making them more susceptible to fractures. PTH injections are designed to stimulate bone formation and increase bone density, which can be beneficial in managing osteoporosis.

Here’s an overview of how parathyroid hormone injections are typically used:

• Osteoporosis Treatment: PTH injections are often prescribed for postmenopausal women and men at high risk of fractures due to severe osteoporosis.
• Fracture Prevention: PTH injections can help reduce the risk of fractures, including spine fractures, in individuals with osteoporosis.
• Bone Health in Men: PTH injections may also be considered for men with osteoporosis or those at risk of fractures.

How should this medicine be used?

Here are some general guidelines for using Parathyroid Hormone Injection:

• Dosage: The dosage and administration of parathyroid hormone injections, such as teriparatide, are typically prescribed by a healthcare provider. The usual recommended dose is once daily.
• Administration: The injection is usually given subcutaneously (under the skin). The injection site can vary, but it is often administered in the thigh or abdominal area.
• Patient Education: Healthcare providers will provide thorough instructions on how to properly administer the injection. Patients may be trained on self-administration if it is deemed appropriate.
• Monitoring: Regular monitoring may be necessary to assess the effectiveness of the treatment and to check for any potential side effects or complications.
• Calcium and Vitamin D Supplementation: Patients on PTH therapy may also be advised to take calcium and vitamin D supplements to ensure adequate nutritional support for bone health.
• Duration of Treatment: The duration of treatment with parathyroid hormone injections is usually limited. After a prescribed period, a healthcare provider may recommend transitioning to other medications or monitoring bone health through alternative means.

It’s crucial for individuals to follow their healthcare provider’s instructions carefully and to communicate any concerns or side effects experienced during the course of treatment. Only a qualified healthcare professional can determine the appropriate use of parathyroid hormone injections based on an individual’s specific medical condition and health history.

Other uses for this medicine

• Osteoporosis Treatment: The primary use of parathyroid hormone injections is for the treatment of osteoporosis in postmenopausal women and men at high risk of fractures.
• Bone Healing: In some cases, parathyroid hormone injections may be used to promote bone healing, such as in fractures that are slow to heal.

What special precautions should I follow?

As for special precautions when using Parathyroid Hormone Injection, consider the following:

• Pregnancy and Breastfeeding: The safety of PTH injections during pregnancy and breastfeeding is not well-established. It is crucial to inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Previous Radiation Therapy: If you have undergone radiation therapy or have a history of radiation exposure, discuss this with your healthcare provider, as it may impact the decision to use PTH injections.
• Kidney Function: Individuals with impaired kidney function may require adjustments in dosage or additional monitoring when using PTH injections. Your healthcare provider will assess your kidney function before prescribing this medication.
• History of Bone Cancer: Individuals with a history of bone cancer or other malignancies may require careful evaluation and monitoring due to concerns about the potential risk of osteosarcoma associated with long-term PTH use.
• Calcium and Vitamin D Levels: Regular monitoring of calcium and vitamin D levels is essential during PTH treatment. Your healthcare provider may recommend supplements to maintain adequate levels.
• Orthostatic Hypotension: PTH injections may cause orthostatic hypotension (a sudden drop in blood pressure upon standing). Be cautious when standing up, especially if you feel dizzy.
• Informing Healthcare Providers: Always inform any healthcare provider involved in your care about your use of PTH injections, including dentists and surgeons, as it may influence certain medical procedures.

Remember, these precautions are general guidelines, and your healthcare provider will provide personalized advice based on your specific health history and circumstances. It’s crucial to have open and informed discussions with your healthcare team to ensure safe and effective use of PTH injections.

What special dietary instructions should I follow?

• Calcium and Vitamin D Supplementation: Your healthcare provider may recommend calcium and vitamin D supplements as part of your treatment plan. Follow their instructions regarding dietary sources and supplements to support bone health.
• Hydration: Maintaining adequate hydration is important for overall health, including bone health. Ensure that you are consuming an appropriate amount of fluids daily, unless otherwise advised by your healthcare provider.

What should I do if I forget a dose?

• Missed Dose: If you forget to take a dose of parathyroid hormone, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Double Dosing: Do not double the dose to make up for a missed one. Taking two doses close together may increase the risk of side effects.
• Consult Your Healthcare Provider: If you have questions about what to do if you miss a dose or if you experience difficulties with the dosing schedule, consult your healthcare provider for guidance.

What side effects can this medication cause?

Parathyroid hormone (PTH) injections, such as teriparatide, can be associated with various side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary among individuals. If you are prescribed parathyroid hormone injections, your healthcare provider will monitor you for potential side effects and discuss the benefits and risks of the medication. Common side effects may include:

• Nausea: Some individuals may experience nausea after receiving a parathyroid hormone injection.
• Dizziness: Feeling lightheaded or dizzy can occur, especially when standing up quickly. This may be related to orthostatic hypotension.
• Headache: Headaches are a reported side effect in some people using PTH injections.
• Leg Cramps: Painful cramps in the legs may occur as a side effect of parathyroid hormone therapy.
• Injection Site Reactions: Redness, pain, or swelling at the injection site can occur.
• Increased Serum Calcium Levels: Parathyroid hormone injections may lead to an increase in serum calcium levels, a condition known as hypercalcemia. Symptoms of hypercalcemia may include nausea, vomiting, weakness, and confusion.
• Orthostatic Hypotension: A sudden drop in blood pressure upon standing, known as orthostatic hypotension, may occur in some individuals using PTH injections.
• Bone Pain: Some people may experience bone pain or joint pain as a side effect of parathyroid hormone injections.

It’s important to report any side effects to your healthcare provider promptly. Additionally, there are rare but potentially serious concerns associated with long-term use of PTH, such as an increased risk of osteosarcoma (a type of bone cancer). This risk is not well-established, and further research is needed to determine the extent of the association.

If you experience severe or persistent side effects, or if you have concerns about your medication, contact your healthcare provider. They can provide guidance on managing side effects or may adjust your treatment plan if necessary. Do not discontinue the medication without consulting your healthcare provider, as abrupt discontinuation can have its own risks. Always follow your healthcare provider’s recommendations and attend regular check-ups to monitor your response to the medication.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage:
  • Follow the storage instructions provided by your healthcare provider or on the medication packaging.
  • Typically, parathyroid hormone injections are stored in the refrigerator.
  • Keep the medication in its original packaging to protect it from light.
• Disposal:
  • Dispose of unused or expired medication as directed by your healthcare provider or pharmacist.
  • Do not flush medications down the toilet unless instructed to do so.
  • Check with your local pharmacy or healthcare facility for information on safe medication disposal in your area.

In case of emergency/overdose

• Emergency Assistance: If you suspect an overdose or experience severe side effects, seek emergency medical attention immediately. Contact your local poison control center or emergency room for guidance.
• Symptoms of Overdose: Overdose symptoms may include severe nausea, vomiting, weakness, confusion, and symptoms of hypercalcemia (elevated calcium levels).

What other information should I know?

• Regular Follow-up: Attend all scheduled follow-up appointments with your healthcare provider to monitor your response to the medication and assess for any potential side effects.
• Lab Tests: Your healthcare provider may order regular blood tests to monitor calcium and other relevant levels while you are on parathyroid hormone therapy.
• Diet and Supplements: Follow any dietary recommendations provided by your healthcare provider, especially regarding calcium and vitamin D intake.
• Informing Healthcare Providers: Make sure all healthcare providers involved in your care are aware of your use of parathyroid hormone injections. This includes dentists, surgeons, and other specialists.
• Medication Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as some may interact with parathyroid hormone injections.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of parathyroid hormone therapy with your healthcare provider.
• Patient Education: Understand the proper technique for administering injections if you are required to self-administer. Your healthcare provider or a healthcare professional will provide thorough instructions.

Always follow the specific guidance provided by your healthcare provider. If you have any questions or concerns about your medication, do not hesitate to contact your healthcare team for clarification and advice. This information is a general guide, and individual circumstances may vary.