WARNING

Quetiapine is an atypical antipsychotic medication used to treat conditions such as schizophrenia, bipolar disorder, and major depressive disorder. While it can be effective in managing certain mental health symptoms, like any medication, quetiapine is associated with certain risks and side effects. Here’s a brief overview:

• Sedation and Drowsiness: Quetiapine can cause significant sedation, leading to drowsiness and impaired alertness. This effect can be particularly pronounced when starting the medication or when the dosage is increased.
• Weight Gain: Many individuals taking quetiapine may experience weight gain. This can be a concern, especially for those who are already at risk for obesity or related health issues.
• Metabolic Effects: Quetiapine has been associated with metabolic changes, including an increased risk of diabetes and elevated cholesterol levels. Regular monitoring of blood glucose and lipids may be necessary for individuals on long-term quetiapine therapy.
• Orthostatic Hypotension: Some people may experience a drop in blood pressure upon standing, leading to dizziness or fainting. This is known as orthostatic hypotension and can be a concern, especially in elderly individuals.
• Increased Prolactin Levels: Quetiapine may elevate levels of the hormone prolactin, potentially leading to side effects such as menstrual irregularities, breast enlargement (gynecomastia), and lactation.
• Movement Disorders: Like other antipsychotic medications, quetiapine may be associated with movement disorders such as tardive dyskinesia, which involves involuntary movements of the face and body.
• Cardiac Effects: Quetiapine can have an impact on the QT interval, which is a measure of the electrical activity of the heart. This could potentially lead to irregular heartbeats, though this is relatively rare.
• Neurological Effects: In some cases, quetiapine has been linked to neurological side effects such as seizures, particularly at higher doses.
• Withdrawal Symptoms: Abrupt discontinuation of quetiapine can lead to withdrawal symptoms, including insomnia, nausea, and anxiety. It’s important to taper the medication under the guidance of a healthcare professional.

It’s crucial to note that the benefits and risks of quetiapine should be carefully considered by a healthcare provider based on an individual’s specific medical history and condition. Any concerns or side effects should be promptly reported to a healthcare professional for evaluation and appropriate management.

Why is this medication prescribed?

Quetiapine is a medication that belongs to a class of drugs known as atypical antipsychotics. It is primarily prescribed for the treatment of certain mental/mood conditions, including:

• Schizophrenia: Quetiapine can be used to manage symptoms of schizophrenia, a mental disorder characterized by distorted thinking, hallucinations, and a reduced ability to feel normal emotions.
• Bipolar Disorder: It is also prescribed for the treatment of bipolar disorder (manic-depressive illness). This condition involves episodes of mood swings, including depressive and manic episodes.
• Major Depressive Disorder (as an adjunct treatment): Quetiapine may be used as an adjunct (additional) treatment to antidepressant medications for major depressive disorder.
• Generalized Anxiety Disorder: Quetiapine may be prescribed off-label for the treatment of generalized anxiety disorder.

How should this medicine be used?

Here are some key points regarding the use of quetiapine:

• Dosage: The dosage of quetiapine will depend on the specific condition being treated, the severity of symptoms, and individual response to the medication. It’s important to take the medication exactly as prescribed by the healthcare provider.
• Form: Quetiapine is available in various forms, including tablets and extended-release tablets. The extended-release form is usually taken once daily, typically in the evening.
• Food: It can be taken with or without food. However, taking it with a meal may help reduce the risk of certain side effects, such as drowsiness.
• Consistency: It is important to take quetiapine consistently and at the same time each day to maintain a steady level of the medication in the blood.
• Follow Instructions: Follow the instructions provided by the healthcare provider carefully. Do not stop taking quetiapine suddenly without consulting your healthcare provider, as abrupt discontinuation can lead to withdrawal symptoms.
• Monitoring: Regular monitoring by a healthcare professional is essential to assess the effectiveness of the medication and to manage any potential side effects.
• Special Considerations: Individuals with certain medical conditions or those taking other medications should inform their healthcare provider before starting quetiapine, as it may interact with other drugs.

Always consult with a healthcare professional for personalized advice and to address any specific concerns or questions related to the use of quetiapine.

Other uses for this medicine

While quetiapine is primarily used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder, it has also been used off-label for conditions such as insomnia and anxiety disorders. However, the off-label use of medications should be done under the guidance and supervision of a qualified healthcare professional.

What special precautions should I follow?

Now, regarding special precautions for quetiapine, it’s important to consider the following:

• Medical History: Before starting quetiapine, inform your healthcare provider about your complete medical history, including any allergies, past or present medical conditions, and a history of substance abuse.
• Pregnancy and Breastfeeding: If you are pregnant or planning to become pregnant, or if you are breastfeeding, discuss the potential risks and benefits with your healthcare provider. Quetiapine may pass into breast milk.
• Elderly Patients: Elderly individuals may be more sensitive to the side effects of quetiapine, especially the risk of falls, dizziness, and drowsiness. Caution is advised in this population.
• Children and Adolescents: Quetiapine is generally not approved for use in children under the age of 10. Its use in adolescents should be carefully monitored, and potential risks and benefits should be discussed with the healthcare provider.
• Diabetes Risk: Quetiapine may increase the risk of high blood sugar (hyperglycemia) and diabetes. Regular monitoring of blood sugar levels is important, especially in individuals with a history of diabetes or those at risk.
• Cardiovascular Risk: Quetiapine may be associated with an increased risk of cardiovascular events, especially in elderly patients with dementia-related psychosis.

Always follow the advice and recommendations of your healthcare provider regarding the use of quetiapine. If you experience any unusual or severe side effects, contact your healthcare provider promptly. It’s essential to attend regular follow-up appointments to monitor your response to the medication and address any concerns.

What special dietary instructions should I follow?

• Food Intake: Quetiapine can be taken with or without food. However, taking it with a meal may help reduce the risk of certain side effects, such as drowsiness.
• Avoid Grapefruit Juice: Some medications can interact with grapefruit juice, potentially affecting their absorption or metabolism. While the interaction between quetiapine and grapefruit juice is not well studied, it’s generally advisable to avoid consuming large quantities of grapefruit juice while taking medications.

What should I do if I forget a dose?

If you forget to take a dose of your medication, the general advice is as follows:

• Take It as Soon as You Remember: If you miss a dose of quetiapine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up to make up for a missed dose.
• Notify Your Healthcare Provider: If you frequently forget doses or are unsure about what to do, contact your healthcare provider for guidance. They may provide specific instructions based on your individual circumstances.

What side effects can this medication cause?

Quetiapine, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary. Common side effects of quetiapine include:

• Sedation or Drowsiness: Quetiapine can cause drowsiness, and individuals taking the medication may feel sleepy or tired. This is often why it is recommended to take it in the evening.
• Weight Gain: Many people experience weight gain while taking quetiapine. This can be a concern, especially over the long term.
• Dizziness: Some individuals may experience dizziness or lightheadedness, especially when standing up quickly. It’s important to get up slowly from a sitting or lying position.
• Constipation: Quetiapine can cause constipation in some people. Maintaining a healthy diet with sufficient fiber and fluid intake can help alleviate this side effect.
• Dry Mouth: Dry mouth is a common side effect of quetiapine. Staying hydrated and using sugar-free gum or candy can help alleviate this symptom.
• Increased Blood Sugar Levels: Quetiapine may cause an increase in blood sugar levels. Regular monitoring of blood sugar is important, especially in individuals with diabetes or at risk of diabetes.
• Orthostatic Hypotension: Some people may experience a drop in blood pressure upon standing, leading to dizziness or fainting. This is more common during the initial days of treatment or when the dosage is increased.
• Increased Cholesterol Levels: Quetiapine may be associated with an increase in cholesterol and triglyceride levels.
• Changes in Blood Cell Counts: In some cases, quetiapine can lead to changes in blood cell counts, such as a decrease in white blood cells. Regular blood tests may be conducted to monitor for these changes.
• Extrapyramidal Symptoms: Although less common with quetiapine compared to some other antipsychotic medications, extrapyramidal symptoms such as tremors, stiffness, and involuntary movements can occur.

It’s important to contact a healthcare provider if you experience severe or persistent side effects. Additionally, some side effects may require immediate medical attention, such as symptoms of high blood sugar (increased thirst, frequent urination, unexplained weight loss) or signs of a serious allergic reaction (rash, itching/swelling, severe dizziness, difficulty breathing).

It’s crucial for individuals taking quetiapine to attend regular check-ups with their healthcare provider to monitor for side effects, assess the effectiveness of the medication, and make any necessary adjustments to the treatment plan.

What should I know about storage and disposal of this medication?

Storage and Disposal of Quetiapine:

• Storage: Keep quetiapine in its original packaging at room temperature, away from moisture and light. Avoid storing it in the bathroom. Follow any specific storage instructions provided by your healthcare provider or the medication’s packaging.
• Keep Out of Reach of Children and Pets: Store quetiapine in a location where children and pets cannot access it. Accidental ingestion can be dangerous.
• Disposal: If your healthcare provider or pharmacist provides specific instructions for disposal, follow those. Otherwise, consult your local guidelines for medication disposal. Do not flush medications down the toilet unless instructed to do so.
• Expired Medication: Dispose of expired or unused quetiapine according to local regulations. Do not keep medications past their expiration date.

In case of emergency/overdose

In case of a suspected overdose or emergency, contact your local poison control center (in the U.S., call 1-800-222-1222) or seek emergency medical attention immediately. Symptoms of quetiapine overdose may include:

• Severe drowsiness
• Fainting
• Increased heart rate
• Uncontrollable movements
• Seizures

What other information should I know?

• Regular Monitoring: Attend regular check-ups with your healthcare provider to monitor the effectiveness of quetiapine and to discuss any side effects or concerns.
• Alcohol and Other Substances: Limit or avoid alcohol while taking quetiapine, as it can enhance the sedative effects of the medication. Inform your healthcare provider about any other medications, supplements, or recreational substances you are taking, as they may interact with quetiapine.
• Driving and Operating Machinery: Quetiapine can cause drowsiness and impair your ability to concentrate. Avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medication affects you.
• Allergies: Inform your healthcare provider about any known allergies, especially to quetiapine or other antipsychotic medications.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of quetiapine with your healthcare provider.
• Suicidal Thoughts: In some cases, antidepressant medications, including quetiapine, may increase the risk of suicidal thoughts or behaviors, particularly in young adults. If you or someone you know is experiencing suicidal thoughts, seek immediate help.

Always follow the advice and recommendations of your healthcare provider. If you have any concerns or questions about quetiapine, do not hesitate to discuss them with your healthcare provider or pharmacist.