Why is this medication prescribed?

Osimertinib is prescribed for the treatment of certain types of non-small cell lung cancer (NSCLC) that have specific mutations in the epidermal growth factor receptor (EGFR) gene. It is specifically used for patients with metastatic NSCLC that has developed resistance to other EGFR tyrosine kinase inhibitors (TKIs), such as erlotinib or gefitinib.

Osimertinib is classified as a third-generation EGFR TKI and is designed to target specific mutations in the EGFR gene, including the T790M mutation. This mutation is commonly associated with resistance to first- and second-generation EGFR TKIs. By inhibiting the activity of mutated EGFR, osimertinib helps to slow down the growth and spread of cancer cells.

The approval and prescription of osimertinib may vary depending on the country and specific guidelines. It is important to consult with a healthcare professional for accurate and up-to-date information regarding the prescription and usage of osimertinib.

How should this medicine be used?

Osimertinib is available in the form of oral tablets and should be taken exactly as prescribed by a healthcare professional. The dosing instructions may vary depending on individual factors such as the specific condition being treated, overall health, and other medications being taken. It is important to follow the instructions provided by the healthcare professional or as indicated on the prescription label.

Here are some general guidelines for the use of Osimertinib:

• Dosage: The recommended dosage of osimertinib may vary, but it is commonly taken as a once-daily dose. The strength of the tablets will be determined by the healthcare professional.
• Timing: Osimertinib can be taken with or without food. However, it is generally recommended to take it at the same time each day to maintain a consistent level of the medication in the body.
• Swallowing: The tablets should be swallowed whole with a glass of water. They should not be crushed, chewed, or dissolved.
• Duration: Osimertinib is usually prescribed for as long as it continues to be effective in treating the cancer and as long as the potential benefits outweigh the risks and side effects. The treatment duration will be determined by the healthcare professional based on individual circumstances.

It is important to adhere to the prescribed dosage and schedule, even if you start feeling better or experience side effects. If you have any questions or concerns about the usage of osimertinib, it is always recommended to consult with a healthcare professional for guidance and clarification.

Other uses for this medicine

Osimertinib is primarily approved and prescribed for the treatment of specific types of non-small cell lung cancer (NSCLC) with certain EGFR mutations. There are no other approved uses for osimertinib. However, ongoing research and clinical trials may explore its potential use in other cancer types or treatment settings.

What special precautions should I follow?

Regarding special precautions, it is crucial to consider the following:

• Allergies: Inform your healthcare professional if you have any known allergies or hypersensitivity to osimertinib or any of its components. This information will help them assess the suitability of the medication for you.
• Medical History: Provide a comprehensive medical history, especially concerning lung or breathing problems, heart disease, liver disease, kidney disease, or any other significant health conditions. Osimertinib may require dosage adjustments or additional monitoring in these cases.
• Pregnancy and Breastfeeding: Osimertinib may cause harm to an unborn baby, so it is important to discuss pregnancy plans or current pregnancy with your healthcare professional. Similarly, the use of osimertinib during breastfeeding is not recommended, as it may pass into breast milk and harm the nursing infant.
• Interactions: Inform your healthcare professional about all the medications, supplements, or herbal products you are currently taking, as they may interact with osimertinib and affect its effectiveness or increase the risk of side effects.
• Side Effects: Osimertinib can cause various side effects, including but not limited to diarrhea, skin rash, nail problems, changes in lung function, cardiovascular effects, and ocular disorders. It is essential to be aware of the potential side effects and promptly report any concerning symptoms to your healthcare professional.

These precautions are not exhaustive, and it is important to consult with a healthcare professional or refer to the prescribing information for a complete list of precautions and warnings associated with osimertinib.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with the use of osimertinib. However, it is generally recommended to take osimertinib with or without food, according to individual preference or as advised by your healthcare professional. If you have any concerns or questions about the timing or combination of osimertinib with meals, it is best to consult with your healthcare provider or pharmacist.

What should I do if I forget a dose?

If you forget to take a dose of osimertinib, take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, contact your healthcare provider or pharmacist for guidance. They can provide specific instructions based on your individual treatment plan.

What side effects can this medication cause?

Osimertinib can cause several side effects. It’s important to note that not all individuals will experience these side effects, and their severity can vary from person to person. Here are some common side effects associated with osimertinib:

• Diarrhea: Osimertinib can cause loose or watery stools. It’s important to stay hydrated and inform your healthcare provider if diarrhea becomes severe or persistent.
• Skin Rash: Some individuals may develop a rash or acne-like skin reactions while taking osimertinib. Inform your healthcare provider if you experience any skin changes.
• Dry Skin: Osimertinib can cause dryness of the skin, including dryness of the hands, feet, and lips. Using moisturizers and lip balms may help alleviate these symptoms.
• Nausea and Vomiting: Osimertinib can cause nausea and vomiting. If these symptoms are bothersome, inform your healthcare provider, as they may be able to prescribe medication to manage them.
• Fatigue: Feeling tired or experiencing fatigue is a common side effect of osimertinib. It’s important to rest when needed and prioritize activities to conserve energy.
• Loss of Appetite: Some individuals may experience a decrease in appetite while taking osimertinib. Maintaining a balanced diet and discussing any concerns with a healthcare provider or a registered dietitian can be helpful.
• Headache: Osimertinib may cause headaches. If headaches are severe or persistent, inform your healthcare provider.
• Shortness of Breath: Difficulty breathing or shortness of breath can occur as a side effect of osimertinib. Notify your healthcare provider immediately if you experience these symptoms.
• Changes in Heart Function: Osimertinib may affect the function of the heart, leading to symptoms such as chest pain or rapid or irregular heartbeat. Report any new or worsening symptoms to your healthcare provider promptly.

It’s important to communicate with your healthcare provider about any side effects you experience while taking osimertinib. They can provide guidance on managing side effects and determine if any adjustments to the treatment plan are necessary.

What should I know about storage and disposal of this medication?

Storage:

• Keep osimertinib in its original container and store it at room temperature, away from excessive heat, moisture, and direct light.
• Do not store osimertinib in the bathroom or kitchen where it might be exposed to moisture.
• Keep osimertinib out of reach and sight of children and pets, as it can be harmful if accidentally ingested.

Disposal:

• It is important to properly dispose of any unused or expired medication to prevent accidental ingestion or environmental contamination.
• Follow any specific disposal instructions provided by your healthcare provider or the local waste disposal regulations.
• If no specific instructions are given, you can consider disposing of osimertinib by mixing it with an undesirable substance like cat litter or coffee grounds in a sealed plastic bag before throwing it in the trash. This helps to prevent accidental ingestion by others.

In case of emergency/overdose

• In case of an emergency or suspected overdose, immediately call your local emergency helpline or go to the nearest emergency room.
• Take the medication container or label with you to provide necessary information to healthcare professionals.
• Do not induce vomiting unless instructed to do so by medical personnel.

What other information should I know?

• Osimertinib is available in tablet form and should be taken exactly as prescribed by your healthcare provider. Follow the instructions on the prescription label carefully.
• Inform your healthcare provider about any other medications, supplements, or herbal products you are taking before starting osimertinib, as it may interact with certain substances.
• Osimertinib may have potential side effects, so it’s essential to discuss any unusual symptoms or concerns with your healthcare provider.
• Attend all scheduled appointments with your healthcare provider to monitor your progress and assess the effectiveness of the medication.

If you have any questions or concerns about osimertinib, its storage, usage, or disposal, consult your healthcare provider or pharmacist for further guidance. They can provide you with specific information based on your individual circumstances.