Why is this medication prescribed?

Onureg (generic name: azacitidine) is a medication that is primarily prescribed for the treatment of a specific type of blood cancer called acute myeloid leukemia (AML). AML is a cancer that affects the bone marrow and blood cells, leading to the rapid growth of abnormal white blood cells.

Onureg is specifically used as maintenance therapy for adult patients with AML who have achieved complete remission (the absence of detectable cancer cells) after intensive chemotherapy. It is prescribed to help prevent the recurrence of leukemia by suppressing the growth of remaining cancer cells and prolonging the duration of remission.

The active ingredient in Onureg, azacitidine, is a type of chemotherapy drug that works by inhibiting the DNA synthesis in cancer cells, leading to their destruction. It is taken orally as a once-daily pill, making it a convenient treatment option for patients who have completed intensive chemotherapy.

How should this medicine be used?

Onureg (azacitidine) is typically available in the form of oral tablets and should be used as directed by your healthcare provider. Here are some general guidelines for the use of Onureg:

• Dosage: The recommended starting dose of Onureg is usually 300 mg (three tablets) taken once daily for 14 days of a 28-day treatment cycle. The tablets should be swallowed whole with a glass of water and can be taken with or without food.
• Cycle: Each treatment cycle consists of 28 days, with 14 days on treatment followed by 14 days off treatment. This 28-day cycle is repeated unless your doctor advises otherwise.
• Compliance: It is important to take Onureg exactly as prescribed by your healthcare provider. Do not modify the dosage or schedule without consulting your doctor.
• Missed Dose: If you miss a dose, take it as soon as you remember on the same day. If it is already the next day, skip the missed dose and resume the regular dosing schedule. Do not take a double dose to make up for a missed one.
• Duration: Your doctor will determine the duration of your treatment with Onureg. It is typically prescribed for long-term maintenance therapy to prevent the recurrence of acute myeloid leukemia (AML).
• Follow-up: Regular follow-up visits with your healthcare provider are essential to monitor your progress, evaluate any side effects, and adjust your treatment plan if necessary.

It is crucial to adhere to your doctor’s instructions and communicate any concerns or side effects you may experience during the treatment with Onureg. They will be able to provide personalized guidance based on your specific condition and response to the medication.

Other uses for this medicine

Onureg (azacitidine) is primarily prescribed for the treatment of acute myeloid leukemia (AML) as maintenance therapy. However, it’s important to note that medications can sometimes be prescribed off-label, meaning they may be used for conditions or purposes other than those specifically approved by regulatory authorities. It is best to consult with a healthcare professional to determine if Onureg is being used for any other specific indications beyond AML.

What special precautions should I follow?

Regarding special precautions, here are some important points to consider when using Onureg:

• Pregnancy and breastfeeding: Onureg may cause harm to unborn babies, so it is not recommended during pregnancy unless the potential benefits outweigh the risks. It is also advised to avoid breastfeeding while taking Onureg, as it may pass into breast milk and harm the nursing infant.
• Blood disorders: Onureg can cause bone marrow suppression, leading to low blood cell counts. Regular monitoring of blood counts is necessary during treatment. If you experience symptoms such as easy bleeding or bruising, persistent infections, or fatigue, inform your healthcare provider.
• Liver or kidney problems: Individuals with pre-existing liver or kidney problems may require dose adjustments or closer monitoring while taking Onureg. Inform your doctor about any history of liver or kidney conditions.
• Interactions with other medications: Onureg may interact with other medications, including those prescribed for other medical conditions. It is important to inform your doctor about all the medications, supplements, or herbal products you are taking to avoid potential drug interactions.
• Side effects: Onureg can cause various side effects, including nausea, vomiting, diarrhea, constipation, loss of appetite, fatigue, weakness, injection site reactions, rash, and low blood cell counts. If you experience severe or persistent side effects, notify your healthcare provider.
• Laboratory tests: Regular monitoring of blood counts and liver function may be required during treatment with Onureg to ensure the medication is not causing any adverse effects.

It is crucial to discuss your medical history, current medications, and any potential risks with your healthcare provider before starting Onureg to ensure its safe and effective use. They will be able to provide you with detailed information and guidance based on your specific circumstances.

What special dietary instructions should I follow?

When taking Onureg (azacitidine), there are no specific dietary restrictions that need to be followed. However, it is generally recommended to maintain a balanced and healthy diet to support overall well-being and manage potential side effects of the medication. It is advisable to consult with a healthcare professional or a registered dietitian for personalized dietary recommendations based on your specific needs.

What should I do if I forget a dose?

If you forget to take a dose of Onureg, here are some general guidelines to follow:

• Timing: If you realize you missed a dose on the same day, take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule.
• Double Dose: Do not take a double dose of Onureg to make up for a missed one. Taking more than the prescribed amount can increase the risk of side effects without providing additional benefit.
• Consult your doctor: It is advisable to inform your healthcare provider about the missed dose. They can provide specific guidance based on your individual circumstances and may adjust your treatment plan if necessary.

What side effects can this medication cause?

Onureg (azacitidine) may cause several side effects, which can vary in severity from person to person. It’s important to note that not all individuals will experience these side effects, and some may experience them to a greater degree than others.

Common side effects of Onureg include:

• Nausea and vomiting
• Diarrhea or constipation
• Loss of appetite
• Fatigue or weakness
• Injection site reactions (if administered as an injection)
• Rash or itching
• Headache
• Muscle or joint pain
• Dizziness
• Easy bruising or bleeding
• Low blood cell counts (anemia, neutropenia, thrombocytopenia)

It’s important to promptly report any severe or persistent side effects to your healthcare provider. In some cases, your doctor may adjust the dosage or provide supportive care to manage these side effects.

Additionally, there are some rare but potentially serious side effects associated with Onureg. Contact your healthcare provider immediately if you experience:

• Signs of an allergic reaction, such as difficulty breathing, hives, or swelling of the face, lips, tongue, or throat.
• Signs of infection, including fever, chills, or persistent sore throat.
• Unusual bleeding or bruising, such as nosebleeds or bleeding gums.
• Unexplained fatigue, shortness of breath, or pale skin, which could indicate low red blood cell count (anemia).
• Severe or persistent nausea, vomiting, or diarrhea.

It is important to discuss any concerns or questions about side effects with your healthcare provider. They can provide you with more specific information based on your individual health profile and offer guidance on managing side effects during your treatment with Onureg.

What should I know about storage and disposal of this medication?

• Storage: Store Onureg tablets at room temperature, preferably between 68°F to 77°F (20°C to 25°C). Keep the tablets in their original container, away from excessive heat, moisture, and direct sunlight.
• Keep out of reach of children and pets: Store Onureg in a secure location, out of the reach of children and pets, to prevent accidental ingestion or misuse.
• Disposal: Properly dispose of any unused or expired Onureg tablets. Follow local regulations and guidelines for the disposal of medications. Do not dispose of medications in household trash or flush them down the toilet unless specifically instructed to do so.

In case of emergency/overdose

• Contact emergency services: If you or someone else may have taken an overdose of Onureg or is experiencing severe symptoms or a life-threatening situation, call emergency services or go to the nearest emergency room immediately.
• Poison Control Center: You can also contact your local Poison Control Center for guidance on what to do in case of an overdose or accidental ingestion. They can provide immediate advice and assistance.

What other information should I know?

• Regular follow-up visits: Attend all scheduled appointments with your healthcare provider for monitoring and assessment of your response to Onureg. This will help ensure the medication’s effectiveness and address any concerns or side effects.
• Laboratory tests: Your doctor may order regular blood tests to monitor your blood cell counts and overall health while taking Onureg. Follow their instructions regarding the timing and frequency of these tests.
• Drug interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking. Certain medications may interact with Onureg and affect its effectiveness or increase the risk of side effects.
• Compliance: Take Onureg exactly as prescribed by your healthcare provider. Do not modify the dosage or schedule without consulting your doctor.
• Additional precautions: Discuss any existing medical conditions, such as liver or kidney problems, with your healthcare provider before starting Onureg. They can provide guidance on appropriate use and any necessary precautions.

Always consult your healthcare provider or pharmacist for specific instructions and guidance regarding the storage, disposal, emergencies, and other important aspects of using Onureg.