WARNING

While Onivyde can be an effective treatment for certain types of cancer, it also carries some risks and potential side effects. Here is a brief overview of the risks associated with taking Onivyde:

• Bone marrow suppression: Onivyde can affect the bone marrow, leading to a decrease in the production of blood cells. This can result in an increased risk of infections, anemia, and bleeding problems.
• Gastrointestinal side effects: Onivyde commonly causes diarrhea, nausea, vomiting, and abdominal pain. These symptoms can be severe in some cases and may require medical intervention.
• Neutropenic fever: Onivyde can lower the number of white blood cells, specifically neutrophils, which are important for fighting infections. Severe neutropenia can lead to a fever and increase the risk of developing infections.
• Fatigue: Many people experience fatigue or tiredness while taking Onivyde. It can affect daily activities and quality of life.
• Liver toxicity: Onivyde can cause liver damage, leading to elevated liver enzymes and potentially liver failure. Regular monitoring of liver function is necessary during treatment.
• Hypersensitivity reactions: Some individuals may develop allergic reactions to Onivyde, which can manifest as rash, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat. Immediate medical attention is required in such cases.
• Interactions with other medications: Onivyde can interact with other drugs, including those metabolized by liver enzymes. It is essential to inform the healthcare provider about all medications, supplements, and herbal products being taken to minimize the risk of interactions.

It is important to remember that these are general risks associated with Onivyde, and individual experiences may vary. Patients should discuss the potential risks and benefits with their healthcare provider before starting treatment with Onivyde. Healthcare professionals closely monitor patients receiving Onivyde and take appropriate measures to manage any adverse effects that may arise.

Why is this medication prescribed?

Onivyde (also known as irinotecan liposome injection) is a medication that is prescribed for the treatment of certain types of cancer. Specifically, it is approved for the treatment of metastatic pancreatic cancer in combination with other chemotherapy drugs, fluorouracil, and leucovorin.

Metastatic pancreatic cancer is a particularly aggressive form of cancer that has spread to other parts of the body. Onivyde is used in combination with other chemotherapy drugs to help slow down the progression of the disease and potentially improve survival rates.

Onivyde contains the active ingredient irinotecan, which is an antineoplastic agent. It works by inhibiting an enzyme called topoisomerase I, which is involved in DNA replication and repair. By inhibiting this enzyme, Onivyde helps to prevent cancer cells from dividing and growing, thereby slowing down the progression of the disease.

How should this medicine be used?

Onivyde (irinotecan liposome injection) is administered as an intravenous (IV) infusion, which means it is given directly into a vein. It is important to follow the specific instructions provided by the healthcare professional, as dosing and administration may vary based on the individual’s condition. Here are some general guidelines for the use of Onivyde:

• Administration: Onivyde is typically given by a healthcare professional in a hospital or clinic setting. It is administered through a vein over a specific period of time, usually lasting 90 minutes.
• Treatment schedule: Onivyde is usually given once every two weeks (every 14 days), along with other chemotherapy drugs such as fluorouracil and leucovorin. The exact treatment schedule and duration will be determined by the healthcare provider based on the specific cancer being treated and the individual’s response to treatment.
• Pre-medication: Prior to receiving Onivyde, the healthcare provider may prescribe pre-medications to help prevent or reduce potential side effects. These pre-medications may include drugs to manage nausea and diarrhea.
• Dose adjustments: The dose of Onivyde may need to be adjusted based on individual factors such as body surface area, liver function, and the presence of certain side effects. The healthcare provider will closely monitor the individual’s response to treatment and make any necessary dose modifications.
• Follow-up appointments: Regular follow-up appointments with the healthcare provider are important to assess the effectiveness of the treatment and monitor for any potential side effects. Blood tests and imaging studies may be conducted to evaluate the response to therapy.

It is crucial to adhere to the prescribed treatment schedule and follow the healthcare provider’s instructions regarding Onivyde administration. If there are any concerns or questions about the medication or its use, it is recommended to consult with a healthcare professional for further guidance.

Other uses for this medicine

Onivyde (generic name: irinotecan liposome injection) is a medication primarily used in the treatment of metastatic pancreatic cancer. However, it may also have other off-label uses as determined by healthcare professionals. It’s important to note that off-label uses refer to the use of a medication for a purpose other than the one approved by regulatory authorities. These off-label uses should always be discussed with a qualified healthcare provider.

What special precautions should I follow?

As for special precautions associated with Onivyde, it is crucial to consider the following:

• Allergic reactions: Some individuals may be hypersensitive to Onivyde or any of its components. If you have a known allergy to irinotecan or other medications, inform your healthcare provider before starting Onivyde.
• Diarrhea: Onivyde can cause severe diarrhea, which may require treatment with antidiarrheal medications. Inform your doctor if you experience diarrhea so that appropriate measures can be taken.
• Neutropenia: Onivyde may lead to a decrease in white blood cell count, specifically neutrophils, which are important for fighting infections. Your doctor will monitor your blood counts during treatment to ensure your safety.
• Bone marrow suppression: Onivyde can suppress bone marrow function, which may result in anemia and increased susceptibility to infections. Regular blood tests will be conducted to monitor for any potential complications.
• Interactions with other medications: Onivyde can interact with certain drugs, including those metabolized by the liver enzyme UGT1A1. It is important to inform your healthcare provider about all medications, supplements, or herbal products you are taking to avoid potential interactions.
• Pregnancy and breastfeeding: Onivyde can harm the developing fetus, so it should not be used during pregnancy unless the potential benefits outweigh the risks. Similarly, it is not recommended for use while breastfeeding, as it can pass into breast milk and harm the nursing infant.
• Liver or kidney impairment: Individuals with pre-existing liver or kidney problems may require dosage adjustments or close monitoring while receiving Onivyde.

These precautions are not exhaustive, and it’s crucial to consult with your healthcare provider or read the medication’s prescribing information for a comprehensive understanding of its specific precautions, warnings, and potential side effects.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Onivyde (irinotecan liposome injection). However, it is generally recommended to maintain a healthy and balanced diet during cancer treatment to support overall well-being and manage potential side effects. It is advisable to consult with a registered dietitian or healthcare professional who can provide personalized dietary recommendations based on your specific needs and any side effects you may experience.

What should I do if I forget a dose?

If you forget a dose of Onivyde, it is important to contact your healthcare provider or nurse as soon as possible. They will provide guidance on how to proceed, as missing a dose can impact the effectiveness of the treatment. It is generally not recommended to try and make up for a missed dose on your own without consulting a healthcare professional. They may adjust the treatment schedule or provide alternative instructions based on the specific circumstances and your overall treatment plan.

What side effects can this medication cause?

Onivyde (irinotecan liposome injection) can cause various side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. Some common side effects of Onivyde include:

• Diarrhea: Diarrhea is a frequent side effect of Onivyde and can range from mild to severe. It is important to stay hydrated and inform your healthcare provider if you experience persistent or worsening diarrhea.
• Nausea and vomiting: Onivyde can cause nausea and vomiting, which can be managed with antiemetic medications prescribed by your healthcare provider.
• Fatigue: Fatigue or tiredness is a common side effect of cancer treatments, including Onivyde. Adequate rest, regular exercise within your capacity, and maintaining a balanced diet can help manage fatigue.
• Neutropenia: Onivyde can cause a decrease in the number of white blood cells, specifically neutrophils, which can increase the risk of infections. Your healthcare provider will monitor your blood cell counts and may adjust the treatment if needed.
• Fever: Onivyde may cause neutropenic fever, which is a fever associated with low white blood cell count. It is important to promptly inform your healthcare provider if you develop a fever.
• Loss of appetite: Onivyde can affect your appetite, leading to a reduced desire to eat. Maintaining proper nutrition and discussing any appetite changes with your healthcare provider or a registered dietitian is important.
• Hair loss: Hair loss or thinning may occur as a side effect of Onivyde treatment, although it is typically temporary and reversible.
• Abdominal pain: Some individuals may experience abdominal pain or cramping as a side effect of Onivyde. Inform your healthcare provider if you experience severe or persistent abdominal pain.
• Liver toxicity: Onivyde can affect liver function, leading to elevated liver enzymes. Regular monitoring of liver function through blood tests is necessary during treatment.
• Allergic reactions: While rare, Onivyde can cause allergic reactions. Seek immediate medical attention if you experience symptoms such as rash, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat.

These are not all the possible side effects of Onivyde. It is important to discuss any concerns or side effects you experience with your healthcare provider. They can provide further guidance, offer strategies to manage side effects, and adjust the treatment if necessary.

What should I know about storage and disposal of this medication?

• Storage: Onivyde should be stored in its original packaging at room temperature, away from direct sunlight and moisture. Follow the specific storage instructions provided by the manufacturer or pharmacist. It is important to keep Onivyde out of the reach of children and pets.
• Disposal: Proper disposal of Onivyde is essential to prevent accidental exposure. Do not dispose of Onivyde in regular household trash. Follow local regulations and guidelines for the disposal of chemotherapy drugs. Contact your healthcare provider, pharmacist, or local waste management authorities for guidance on proper disposal methods.

In case of emergency/overdose

• Emergency: If you experience a severe allergic reaction or any other emergency situation, such as difficulty breathing, swelling, or chest pain, seek immediate medical attention. Call your local emergency number or go to the nearest emergency room.
• Overdose: If you suspect an overdose of Onivyde, contact your healthcare provider or go to the nearest emergency room immediately. It is important to provide them with as much information as possible, including the dose taken, the time of ingestion, and any symptoms you may be experiencing.

What other information should I know?

• Inform your healthcare provider about any allergies, medical conditions, or medications you are currently taking before starting Onivyde.
• Onivyde can cause serious harm or death to an unborn baby, so it is important to discuss contraception and pregnancy plans with your healthcare provider.
• Regular blood tests and monitoring will be necessary during treatment to check for any adverse effects and ensure safety.
• Onivyde can interact with certain medications, so inform your healthcare provider about all the medications, supplements, and herbal products you are taking.
• Attend all scheduled appointments and follow your healthcare provider’s instructions regarding dosage, administration, and any necessary precautions.

Remember, this information is not exhaustive, and it is crucial to consult with your healthcare provider or refer to the medication guide for comprehensive guidance and up-to-date information specific to your situation.