Why is this medication prescribed?

Onglyza (generic name: saxagliptin) is a medication prescribed to individuals with type 2 diabetes. It belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. Onglyza is typically used in conjunction with diet and exercise to help control blood sugar levels in adults with type 2 diabetes.

Type 2 diabetes is a condition characterized by the body’s inability to effectively use insulin or produce enough insulin to regulate blood sugar levels. Onglyza works by inhibiting the action of the DPP-4 enzyme, which in turn increases the levels of incretin hormones. Incretin hormones stimulate the release of insulin from the pancreas and reduce the amount of glucose produced by the liver. By enhancing the body’s natural insulin response and reducing excessive glucose production, Onglyza helps to lower blood sugar levels in individuals with type 2 diabetes.

How should this medicine be used?

Onglyza (saxagliptin) is available in tablet form and should be taken orally as prescribed by a healthcare professional. Here are some general guidelines for using Onglyza:

• Dosage: The recommended starting dose of Onglyza is usually 2.5 mg once daily. However, the specific dosage may vary depending on individual factors such as your blood sugar levels and response to the medication. Your doctor will determine the appropriate dosage for you.
• Timing: Onglyza can be taken with or without food. It is generally recommended to take it around the same time each day to help maintain consistent levels of the medication in your body.
• Follow the prescription: It’s important to follow your doctor’s instructions and the prescription label carefully. Do not take more or less Onglyza than prescribed, and do not alter the dosing schedule without consulting your healthcare provider.
• Combination with other medications: Onglyza is often used in combination with other antidiabetic medications, such as metformin. If you are taking multiple medications for diabetes, be sure to follow your doctor’s instructions regarding timing and dosage of each medication.
• Regular monitoring: While taking Onglyza, it is essential to regularly monitor your blood sugar levels as recommended by your healthcare provider. This will help determine the effectiveness of the medication and ensure appropriate adjustments if needed.
• Missed dose: If you miss a dose of Onglyza, take it as soon as you remember. However, if it is close to the time of your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
• Precautions: Inform your doctor about any other medications, supplements, or medical conditions you have before starting Onglyza. They will consider potential drug interactions and any precautions specific to your situation.

Remember, these instructions are general guidelines, and it’s important to consult with your healthcare provider for personalized advice on using Onglyza based on your individual needs and health condition.

Other uses for this medicine

Onglyza (saxagliptin) is primarily prescribed for the treatment of type 2 diabetes. However, it is important to note that medications are typically approved for specific uses based on clinical trials and evidence. Onglyza’s primary approved use is for type 2 diabetes, and it is not commonly prescribed for other conditions.

What special precautions should I follow?

Regarding special precautions, it is crucial to discuss your medical history and any potential contraindications with your healthcare provider before starting Onglyza. Here are some general precautions associated with the use of Onglyza:

• Allergies: Inform your doctor if you have any known allergies to saxagliptin or any other ingredients in Onglyza. Allergic reactions to medications can be serious and may require immediate medical attention.
• Pancreatitis: Onglyza may increase the risk of pancreatitis (inflammation of the pancreas). Inform your doctor if you have a history of pancreatitis or if you experience persistent abdominal pain, nausea, vomiting, or other symptoms of pancreatitis while taking Onglyza.
• Heart failure: Onglyza has been associated with an increased risk of heart failure, particularly in individuals with a history of heart disease. Discuss your cardiovascular health with your doctor before starting Onglyza.
• Kidney function: Onglyza is eliminated from the body primarily through the kidneys. If you have impaired kidney function, your doctor may adjust the dosage or consider alternative treatment options.
• Hypoglycemia (low blood sugar): Onglyza, when used alone, is not likely to cause hypoglycemia. However, if it is combined with other antidiabetic medications that can cause low blood sugar, such as insulin or sulfonylureas, the risk of hypoglycemia may increase. Be cautious and monitor your blood sugar levels regularly.
• Pregnancy and breastfeeding: The safety of Onglyza during pregnancy and breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits with your healthcare provider.
• Other medications: Inform your doctor about all the medications, including over-the-counter drugs and supplements, that you are taking. Certain medications may interact with Onglyza and affect its effectiveness or increase the risk of side effects.

It is important to remember that these precautions are not exhaustive, and it’s essential to consult with your healthcare provider for personalized advice based on your specific medical history and circumstances.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with the use of Onglyza (saxagliptin). However, it is generally recommended to follow a healthy and balanced diet as advised by your healthcare provider. A well-rounded diet that includes whole grains, fruits, vegetables, lean proteins, and limited sugar and saturated fats can help in managing blood sugar levels effectively.

What should I do if I forget a dose?

If you forget to take a dose of Onglyza, you should take it as soon as you remember. However, if it is close to the time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. Taking extra medication to compensate for a missed dose may increase the risk of side effects.

What side effects can this medication cause?

Onglyza (saxagliptin) may cause side effects in some individuals. Not everyone experiences side effects, and the severity and occurrence of side effects can vary.

Common side effects associated with Onglyza include:

• Upper respiratory tract infection
• Headache
• Nasal congestion
• Sore throat
• Urinary tract infection
• Diarrhea
• Nausea
• Stomach discomfort or pain
• Joint pain
• Hypoglycemia (low blood sugar) when used with other antidiabetic medications that can cause hypoglycemia

These side effects are typically mild and temporary. However, if you experience any persistent or severe side effects, it is important to contact your healthcare provider.

In some cases, Onglyza may cause more serious side effects that require immediate medical attention. These can include:

• Pancreatitis: Symptoms may include severe and persistent abdominal pain, which may radiate to the back, accompanied by nausea and vomiting.
• Allergic reactions: This can include symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Heart failure: Symptoms may include shortness of breath, rapid weight gain, and swelling of the ankles or feet.

It’s important to discuss any concerns about potential side effects with your healthcare provider. They can provide you with more detailed information and guidance based on your individual health profile and specific circumstances.

What should I know about storage and disposal of this medication?

Storage and disposal:

• Onglyza should be stored at room temperature, away from moisture and heat.
• Keep the medication in its original container or packaging to protect it from light.
• Ensure that Onglyza is kept out of reach of children and pets.
• Do not use Onglyza if it has expired or if the tablets appear damaged or discolored.
• If you no longer need to use Onglyza or it has reached its expiration date, consult with your pharmacist or healthcare provider regarding proper disposal methods.

In case of emergency/overdose

• If you suspect an overdose or experience severe symptoms, such as difficulty breathing, severe dizziness, or loss of consciousness, immediately call emergency services or go to the nearest emergency room.
• It is helpful to have the Onglyza packaging or container available to provide information about the medication to healthcare professionals.

What other information should I know?

• Regularly monitor your blood sugar levels as recommended by your healthcare provider.
• Inform all healthcare professionals involved in your care, including dentists and surgeons, that you are taking Onglyza.
• Attend regular follow-up appointments with your doctor to evaluate the effectiveness of the medication and monitor for any potential side effects or complications.
• If you experience any new symptoms or have concerns while taking Onglyza, promptly discuss them with your healthcare provider.
• Do not share Onglyza with others, as it is prescribed specifically for individual treatment.

It is important to note that the information provided here is based on general guidelines, and specific instructions and recommendations may vary. Always follow the instructions provided by your healthcare provider and refer to the medication package insert for complete and accurate information about Onglyza.