Why is this medication prescribed?

Omacetaxine injection is a prescription medication used in the treatment of certain types of leukemia. Specifically, it is indicated for the treatment of chronic myeloid leukemia (CML) in adults who have not responded to, or cannot tolerate, other therapies such as tyrosine kinase inhibitors (TKIs).

Omacetaxine is a protein synthesis inhibitor that works by blocking the production of proteins necessary for the growth and survival of cancer cells. By inhibiting protein synthesis, it helps to slow down or stop the growth of leukemia cells.

How should this medicine be used?

Omacetaxine Injection, also known by its brand name Synribo, is a medication used to treat certain types of chronic myeloid leukemia (CML). It is typically prescribed for patients who have not responded to or cannot tolerate other available treatments.

Omacetaxine Injection is administered as an intravenous (IV) infusion, which means it is injected directly into a vein. It should only be given under the supervision of a healthcare professional, such as a doctor or nurse, in a hospital or clinical setting.

The dosage and treatment schedule for Omacetaxine Injection can vary depending on individual factors, such as the patient’s overall health, the stage of leukemia, and their response to the treatment. Your doctor will determine the appropriate dose and schedule for you.

It’s important to follow your doctor’s instructions carefully and not to change the dosage or schedule without consulting them. If you have any questions or concerns about the proper use of Omacetaxine Injection, it is best to discuss them with your healthcare provider, who can provide you with personalized guidance and address your specific needs.

Other uses for this medicine

Omacetaxine injection is primarily used for the treatment of chronic myeloid leukemia (CML). However, it may have off-label or investigational uses in certain situations. Off-label use refers to the use of a medication for a purpose other than its approved indication. It’s important to note that off-label use should only be done under the guidance and supervision of a healthcare professional.

What special precautions should I follow?

As for special precautions associated with omacetaxine injection, here are a few important points to consider:

• Allergies: Inform your healthcare provider if you have any known allergies, especially to omacetaxine or any of its components. Allergic reactions to omacetaxine can be serious and may include symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Pregnancy and breastfeeding: Omacetaxine may cause harm to a developing fetus, so it is generally not recommended during pregnancy unless the potential benefits outweigh the risks. It is important to discuss the potential risks and benefits with your healthcare provider. Similarly, it is not known if omacetaxine passes into breast milk, so breastfeeding is not recommended during treatment with omacetaxine.
• Bone marrow suppression: Omacetaxine may cause a decrease in blood cell counts, including red blood cells, white blood cells, and platelets. Regular blood tests will be conducted to monitor your blood cell counts during treatment. Your healthcare provider will determine the appropriate course of action if any abnormalities are detected.
• Drug interactions: Inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Omacetaxine may interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects.
• Liver and kidney function: Omacetaxine should be used with caution in patients with liver or kidney problems, as it may affect these organs. Your healthcare provider will monitor your liver and kidney function during treatment.

These are just a few general precautions associated with omacetaxine injection. It’s important to consult with your healthcare provider for a comprehensive understanding of the specific precautions, warnings, and potential side effects related to your individual circumstances.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Omacetaxine Injection. However, it is always important to maintain a healthy and balanced diet during cancer treatment to support your overall well-being. You may consult with a registered dietitian or your healthcare provider for personalized dietary recommendations based on your specific needs and treatment plan.

What should I do if I forget a dose?

If you forget a dose of Omacetaxine Injection, it is important to contact your healthcare provider or follow their instructions. They will be able to provide guidance on whether you should take the missed dose or adjust your dosing schedule. It’s generally not recommended to administer a double dose to make up for a missed one without consulting your healthcare provider, as they will have the best understanding of your treatment plan and can advise you accordingly.

What side effects can this medication cause?

Omacetaxine injection may cause several side effects. It’s important to note that not all individuals will experience these side effects, and their severity can vary from person to person. Some of the common side effects of Omacetaxine Injection include:

• Injection site reactions: Pain, redness, swelling, or bruising at the injection site are common. These reactions are usually temporary and resolve on their own.
• Fatigue: Feeling tired or weak is a commonly reported side effect of omacetaxine.
• Nausea and vomiting: Some individuals may experience nausea and vomiting during treatment. Anti-nausea medications may be prescribed to help manage these symptoms.
• Diarrhea or constipation: Changes in bowel movements, such as diarrhea or constipation, can occur.
• Headache: Headaches are a possible side effect, but they are generally mild.
• Fever: Some individuals may experience a fever during treatment with omacetaxine.
• Decreased appetite: A reduced desire to eat or loss of appetite can occur.
• Muscle and joint pain: Musculoskeletal pain, including muscle aches and joint discomfort, may be experienced.
• Bruising or bleeding: Omacetaxine can affect blood cell counts, which may lead to an increased risk of bruising or bleeding.
• Infections: Omacetaxine can lower your body’s ability to fight infections, making you more susceptible to infections. Notify your healthcare provider if you develop signs of an infection, such as fever, chills, or sore throat.
• Electrolyte imbalances: Omacetaxine can affect the balance of electrolytes in the body, which may lead to symptoms such as weakness, confusion, or irregular heartbeat.

It’s important to promptly report any side effects or concerns to your healthcare provider. They can provide guidance on managing the side effects and may recommend supportive care measures or adjustments to your treatment if needed.

What should I know about storage and disposal of this medication?

Storage:

• Omacetaxine injection should be stored in the refrigerator between 2°C and 8°C (36°F and 46°F). Do not freeze the medication.
• Keep the vials in their original packaging until ready for use to protect them from light.
• If necessary, during administration, the vials can be removed from the refrigerator and kept at room temperature (up to 25°C or 77°F) for up to 12 hours.
• Follow the specific storage instructions provided by your healthcare provider or on the medication packaging.

Disposal:

• Proper disposal of unused or expired medication is important to prevent accidental ingestion, misuse, or environmental contamination.
• Follow local regulations and guidelines for the disposal of medical waste and unused medications. You can consult your pharmacist or healthcare provider for guidance on the proper disposal methods in your area.

In case of emergency/overdose

• In the case of an emergency or overdose, immediately contact your local emergency services or go to the nearest emergency room.
• You can also contact the poison control center at 1-800-222-1222 (in the United States) for further assistance.

What other information should I know?

• Omacetaxine is a prescription medication and should only be used under the guidance and supervision of a healthcare professional.
• Attend all scheduled appointments with your healthcare provider for regular monitoring and follow-up during your treatment.
• Inform all healthcare providers involved in your care, including dentists and specialists, about your treatment with omacetaxine.
• It’s important to understand that this response provides general information and does not replace the advice and instructions given by your healthcare provider. Always consult with your healthcare provider for personalized guidance and to address any specific concerns you may have.