Why is this medication prescribed?

Nusinersen Injection is prescribed for the treatment of spinal muscular atrophy (SMA) in both pediatric and adult patients. SMA is a genetic disorder that affects the motor neurons in the spinal cord and leads to muscle weakness and atrophy.

Nusinersen Injection is a medication that specifically targets the underlying cause of SMA. It works by increasing the production of a protein called survival motor neuron (SMN) that is essential for the proper functioning of motor neurons. By increasing SMN levels, Nusinersen helps improve motor neuron function and overall muscle strength in individuals with SMA.

The administration of Nusinersen Injection involves a series of intrathecal injections, which means the medication is delivered directly into the cerebrospinal fluid surrounding the spinal cord. Typically, the injections are performed by a healthcare professional, such as a neurologist or a specialist familiar with SMA treatment.

How should this medicine be used?

The dosing and administration schedule for Nusinersen Injection may vary depending on the patient’s age and specific condition. The treatment usually begins with an initial loading phase, where several injections are given over a period of time to achieve an appropriate therapeutic level of the medication. After the loading phase, maintenance doses are administered at regular intervals to sustain the treatment’s benefits.

It’s crucial to follow the healthcare professional’s instructions regarding the dosage and administration of Nusinersen Injection. They will determine the appropriate dosage, frequency, and duration of the treatment based on the individual’s specific needs and response to the medication.

If you or someone you know is prescribed Nusinersen Injection, it’s essential to consult with a healthcare professional for detailed guidance and clarification on the proper usage and administration of the medication.

Other uses for this medicine

Nusinersen Injection is primarily used for the treatment of spinal muscular atrophy (SMA) and there are no other approved uses for this medication. However, it’s important to consult with a healthcare professional or refer to the latest medical information for any potential updates or new uses.

What special precautions should I follow?

When it comes to special precautions, it’s crucial to discuss the individual’s medical history and any current medications or conditions with a healthcare professional before starting Nusinersen Injection. Here are some general precautions to consider:

• Allergies: Individuals who have a known allergy or hypersensitivity to Nusinersen or any of its components should not use this medication.
• Bleeding disorders: Nusinersen Injection may increase the risk of bleeding, especially if the individual has a pre-existing bleeding disorder or is taking medications that affect blood clotting. It’s important to inform the healthcare professional about any bleeding disorders or medications being used.
• Infections: Nusinersen Injection can potentially increase the risk of infections, particularly those involving the central nervous system. If the individual has an active infection or a history of recurrent infections, it should be discussed with the healthcare professional prior to initiating treatment.
• Drug interactions: It’s important to inform the healthcare professional about all medications, supplements, or herbal products being taken, as certain medications may interact with Nusinersen Injection. They can evaluate potential interactions and adjust the treatment plan accordingly.
• Pregnancy and breastfeeding: The safety of Nusinersen Injection during pregnancy or breastfeeding has not been established. If an individual is pregnant, planning to become pregnant, or breastfeeding, it’s crucial to discuss the potential risks and benefits of using this medication with a healthcare professional.
• Adverse reactions: Nusinersen Injection may be associated with certain side effects, including headache, back pain, respiratory infections, and constipation. It’s important to report any unusual or severe side effects to a healthcare professional.

These precautions are not exhaustive, and it’s essential to consult with a healthcare professional for comprehensive guidance specific to the individual’s situation before initiating treatment with Nusinersen Injection.

What special dietary instructions should I follow?

There are no specific special dietary instructions associated with Nusinersen Injection. However, it’s always advisable to maintain a balanced and healthy diet to support overall well-being.

What should I do if I forget a dose?

If you forget a dose of Nusinersen Injection, it’s important to contact your healthcare professional or the prescribing physician as soon as possible. They can provide guidance on how to proceed based on the specific treatment plan and the length of time since the missed dose. It’s generally recommended to follow the healthcare professional’s instructions and resume the dosing schedule as directed. It’s important not to double up on doses unless specifically instructed to do so by a healthcare professional.

What side effects can this medication cause?

Nusinersen Injection may cause side effects in some individuals. It’s important to note that not all people will experience these side effects, and their severity can vary. Common side effects reported with Nusinersen Injection include:

• Headache: Mild to moderate headaches are commonly reported. If the headache becomes severe or persists, it’s advisable to consult with a healthcare professional.
• Back pain: Some individuals may experience back pain following the administration of Nusinersen Injection. It’s recommended to inform the healthcare professional if the back pain is severe or persistent.
• Injection site reactions: Redness, pain, swelling, or bruising at the injection site can occur. These reactions are usually mild and resolve on their own. Inform your healthcare professional if you experience any unusual or severe reactions.
• Respiratory infections: In clinical trials, individuals treated with Nusinersen Injection were more likely to develop respiratory infections, such as upper respiratory tract infections or pneumonia. It’s important to promptly report any symptoms of respiratory infections, such as cough, fever, or difficulty breathing, to a healthcare professional.
• Constipation: Nusinersen Injection may cause constipation in some individuals. Maintaining a healthy diet, staying hydrated, and engaging in regular physical activity can help manage this side effect. If constipation persists or becomes severe, consult with a healthcare professional.

It’s worth noting that these are not the only possible side effects of Nusinersen Injection. Some individuals may experience other, less common side effects. If you notice any unusual or bothersome symptoms while receiving Nusinersen Injection, it’s important to inform your healthcare professional promptly. They can provide guidance, evaluate the symptoms, and make any necessary adjustments to your treatment plan.

What should I know about storage and disposal of this medication?

Storage and disposal:

• Nusinersen Injection should be stored in a refrigerator between 2°C and 8°C (36°F and 46°F). Do not freeze the medication.
• Keep the vials in the original carton to protect them from light.
• Do not use Nusinersen Injection beyond the expiration date printed on the packaging.

Disposal of Nusinersen Injection should be done according to local regulations. It is advisable to consult with a healthcare professional or local waste management authorities to determine the appropriate disposal method for unused or expired medication.

In case of emergency/overdose

• If you believe you or someone else may have overdosed on Nusinersen or is experiencing a severe adverse reaction, immediately contact emergency services or go to the nearest emergency room.
• It’s important to bring the medication packaging or vials to the healthcare facility to assist with medical treatment and provide relevant information.

What other information should I know?

• Regular monitoring and follow-up appointments with the healthcare professional are necessary to evaluate the effectiveness of the treatment and manage any potential side effects.
• Inform your healthcare professional about all medications, supplements, or herbal products you are taking, as they can interact with Nusinersen Injection.
• Keep a record of the dates and times of the injections to ensure adherence to the prescribed dosing schedule.
• It’s important to attend all scheduled appointments and laboratory tests recommended by the healthcare professional.
• If you have any questions, concerns, or experience any new symptoms or side effects, contact your healthcare professional for guidance and support.

Remember, the information provided here is based on the available knowledge. It’s essential to consult with a healthcare professional or refer to the latest medical information for the most accurate and up-to-date guidance on the storage, disposal, emergency situations, and other pertinent information regarding Nusinersen Injection.