Why is this medication prescribed?

Nucala (mepolizumab) is a prescription medication that is primarily used for the treatment of severe eosinophilic asthma. It is prescribed to adults and children aged 6 years and older who have a history of frequent asthma attacks despite receiving standard asthma medications.

Eosinophilic asthma is a subtype of asthma characterized by high levels of eosinophils, a type of white blood cell, in the airways. Nucala is a monoclonal antibody that specifically targets and blocks an immune system protein called interleukin-5 (IL-5), which plays a key role in the production and activation of eosinophils. By reducing the levels of eosinophils in the airways, Nucala helps to decrease inflammation and prevent asthma exacerbations.

Nucala is usually prescribed as an add-on treatment for patients who have not achieved adequate asthma control with their current medications, such as inhaled corticosteroids and long-acting beta-agonists. It is administered by subcutaneous injection once every four weeks, either by a healthcare professional or self-administered by the patient after appropriate training.

How should this medicine be used?

Nucala (mepolizumab) is available as a prescription medication and should be used according to the instructions provided by your healthcare professional. Here are the general guidelines for using Nucala:

• Administration: Nucala is administered by subcutaneous injection, which means it is injected under the skin. The injections are usually given in the upper arm, thigh, or abdomen.
• Frequency: Nucala is typically administered once every four weeks (every 28 days). It is important to adhere to the recommended dosing schedule as prescribed by your healthcare professional.
• Injection Site: Your healthcare professional will guide you on the proper injection technique and the recommended injection site. They may advise rotating the injection site with each dose to minimize the risk of injection site reactions.
• Preparation: Nucala is supplied as a pre-filled syringe or a pre-filled pen. Follow the instructions provided with the packaging on how to prepare the syringe or pen for injection.
• Self-administration: Depending on your healthcare professional’s guidance and your ability to self-administer the medication, you may be trained to administer Nucala injections yourself. If self-administering, carefully follow the instructions provided by your healthcare professional.
• Missed Dose: If you miss a scheduled dose of Nucala, contact your healthcare professional to discuss the next steps. It is important to maintain regular dosing intervals to achieve the desired treatment outcomes.

Remember, the above information is a general overview, and it’s crucial to follow the specific instructions provided by your healthcare professional or the product labeling for your individual circumstances. If you have any questions or concerns about using Nucala, consult with your healthcare provider for personalized advice.

Other uses for this medicine

Nucala (mepolizumab) is primarily approved for the treatment of severe eosinophilic asthma. Nucala is also approved for the treatment of EGPA, a rare autoimmune disease characterized by inflammation of blood vessels and the presence of eosinophils in various tissues. Nucala can help reduce asthma exacerbations and improve symptoms in patients with EGPA.

What special precautions should I follow?

Special precautions should be taken when using Nucala. Here are some important considerations:

• Allergy or hypersensitivity: If you have a known allergy or hypersensitivity to mepolizumab or any of its components, inform your healthcare professional. Hypersensitivity reactions, including anaphylaxis, have been reported with Nucala.
• Parasitic infections: Nucala may affect the body’s immune response to certain parasitic infections. Before initiating treatment, your healthcare professional should evaluate and treat any parasitic infections, if present.
• Asthma exacerbations: Nucala is not intended to treat acute asthma exacerbations or bronchospasm. It is important to continue using your rescue inhaler as prescribed for sudden asthma symptoms.
• Corticosteroid reduction: Nucala may allow for a reduction in the use of oral corticosteroids in some patients. However, it should be done under the supervision of your healthcare professional, as abrupt discontinuation of systemic corticosteroids can lead to adrenal insufficiency.
• Pregnancy and breastfeeding: The safety of Nucala in pregnant or breastfeeding individuals is not well-established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Nucala with your healthcare professional.
• Drug interactions: Nucala is not known to have significant interactions with other medications. However, it’s important to inform your healthcare professional about all the medications, including over-the-counter drugs and supplements, that you are taking to ensure safe and effective use.

As with any medication, it is essential to follow your healthcare professional’s instructions, adhere to the prescribed dosage, and discuss any specific concerns or medical conditions you have before starting Nucala. They can provide you with the most accurate and personalized advice based on your individual situation.

What special dietary instructions should I follow?

Regarding special dietary instructions for Nucala, there are no specific dietary restrictions associated with this medication. However, it’s always a good idea to maintain a healthy and balanced diet to support your overall well-being and manage your condition effectively. You may want to consult with a registered dietitian or healthcare professional to discuss any specific dietary considerations you may have.

What should I do if I forget a dose?

If you forget to take a dose of Nucala, it’s important to contact your healthcare provider or follow the instructions provided in the medication’s prescribing information. They will be able to provide guidance on the best course of action based on your individual circumstances. It’s generally not advisable to administer a double dose to make up for a missed one unless explicitly instructed by your healthcare provider.

What side effects can this medication cause?

Nucala (mepolizumab) is generally well-tolerated, but like any medication, it can cause side effects in some individuals. The most common side effects associated with Nucala include:

• Headache
• Injection site reactions (such as pain, redness, swelling, or itching at the injection site)
• Back pain
• Fatigue
• Hypersensitivity reactions (including rash, hives, itching, swelling, or difficulty breathing)

These side effects are typically mild to moderate in severity and tend to improve over time. However, if you experience any persistent or severe side effects, it’s important to inform your healthcare professional.

In rare cases, Nucala may cause more serious side effects. Contact your healthcare professional immediately if you experience any of the following:

• Allergic reactions: Signs of an allergic reaction may include hives, swelling of the face, lips, tongue, or throat, difficulty breathing, or severe itching.
• Herpes zoster (shingles): Some patients treated with Nucala have reported cases of shingles. Seek medical attention if you develop a rash or experience symptoms like pain, burning, or tingling, as these may be signs of shingles.
• Parasitic infections: In rare cases, Nucala may lead to an increased risk of parasitic infections. Inform your healthcare professional if you experience symptoms such as persistent fever, muscle aches, cough, or respiratory problems.

It’s important to note that this is not an exhaustive list of side effects. Different individuals may experience different reactions to medications. If you have any concerns or questions about the potential side effects of Nucala, consult with your healthcare professional for personalized advice. They can provide you with more detailed information based on your specific medical history and circumstances.

What should I know about storage and disposal of this medication?

• Storage: Nucala should be stored in the refrigerator between 2°C and 8°C (36°F and 46°F). Keep the medication in its original carton to protect it from light. Do not freeze Nucala. If needed, Nucala can be stored at room temperature (up to 30°C or 86°F) for a maximum of 7 days, but it should be used or returned to the refrigerator as soon as possible.
• Disposal: Dispose of used Nucala syringes or pens in accordance with local regulations or guidelines. Consult with your healthcare professional or pharmacist on the appropriate method of disposal.

In case of emergency/overdose

In case of an emergency or overdose, contact emergency medical services immediately (e.g., call your local emergency hotline) or seek immediate medical attention. It’s important to inform the healthcare professionals about the medication involved and provide them with any relevant information.

What other information should I know?

• Regular Follow-up: It is important to continue regular check-ups and follow-up appointments with your healthcare professional while using Nucala. They will monitor your progress, assess the effectiveness of the medication, and make any necessary adjustments to your treatment plan.
• Compliance: It is essential to adhere to the prescribed dosing schedule and follow your healthcare professional’s instructions regarding the use of Nucala. If you have any questions or concerns about the medication or its administration, consult your healthcare professional for clarification.
• Carry Medication Information: It may be helpful to carry a card or other form of identification indicating that you are receiving Nucala. This can be useful in case of emergencies or if you require medical attention from healthcare professionals who may not be familiar with your treatment.
• Drug Interactions: Inform your healthcare professional about all medications, including prescription drugs, over-the-counter medications, and supplements, that you are taking. This will help them identify any potential drug interactions and adjust your treatment plan accordingly.

Remember, the information provided here is a general overview. Always consult with your healthcare professional or pharmacist for specific instructions, guidelines, and any additional information related to the storage, disposal, emergency situations, or other aspects of using Nucala. They can provide you with the most accurate and up-to-date information based on your individual circumstances.