Why is this medication prescribed?

Nubeqa (generic name: darolutamide) is a medication prescribed for the treatment of prostate cancer. Specifically, it is used for the treatment of non-metastatic castration-resistant prostate cancer (nmCRPC).

Prostate cancer is a type of cancer that develops in the prostate gland, which is a small walnut-shaped gland that produces seminal fluid. In some cases, prostate cancer can progress despite hormonal therapy (also known as castration-resistant prostate cancer). Non-metastatic castration-resistant prostate cancer refers to a stage where the cancer has not spread to other parts of the body, such as the bones or organs.

Nubeqa works by blocking the actions of androgens, which are male hormones like testosterone, that can stimulate the growth of prostate cancer cells. By inhibiting the androgen receptors, Nubeqa helps slow down the progression of prostate cancer and delay the spread of the disease.

How should this medicine be used?

Nubeqa (darolutamide) should be used exactly as prescribed by a healthcare professional. It is typically available in the form of oral tablets. Here are some general guidelines for using Nubeqa:

• Dosage: The recommended dose of Nubeqa is 600 mg (two 300 mg tablets) taken orally once daily.
• Timing: It is usually taken at the same time each day to maintain a consistent level of the medication in the body.
• Swallowing: The tablets should be swallowed whole with water. Do not crush, chew, or break the tablets.
• Food: Nubeqa can be taken with or without food. However, it is generally recommended to take it consistently in the same manner (with or without food) throughout the treatment.
• Duration of treatment: The duration of Nubeqa treatment will be determined by the healthcare professional based on the individual’s condition and response to the medication. It is important to follow the prescribed treatment plan and not stop taking Nubeqa without consulting the healthcare professional.
• Missed dose: If a dose is missed, it should be taken as soon as possible unless it is close to the time for the next scheduled dose. In such cases, the missed dose should be skipped, and the regular dosing schedule should be resumed. It is important not to take a double dose to make up for a missed one.

It is essential to follow the specific instructions provided by the prescribing healthcare professional. They will provide personalized guidance on the proper use of Nubeqa based on individual circumstances and medical history.

Other uses for this medicine

Nubeqa (generic name: darolutamide) is a medication primarily used in the treatment of prostate cancer. However, it is always important to consult with a healthcare professional for specific medical advice. While Nubeqa is primarily indicated for prostate cancer, it is essential to note that medications are typically prescribed based on individual circumstances and medical history.

What special precautions should I follow?

Regarding special precautions for Nubeqa, here are some general considerations:

• Allergies: Inform your healthcare provider if you have any known allergies or hypersensitivity to darolutamide or any other medications.
• Pregnancy and breastfeeding: Nubeqa may cause harm to a developing fetus, so it should not be used during pregnancy. Additionally, it is not known whether Nubeqa passes into breast milk, so it is recommended to avoid breastfeeding while taking the medication.
• Liver function: Nubeqa is primarily metabolized in the liver. Therefore, individuals with liver problems or impaired liver function may require specific monitoring or dosage adjustments.
• Interactions with other medications: Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Certain medications, such as those that affect liver enzymes or blood clotting, may interact with Nubeqa.
• Side effects: Like any medication, Nubeqa may cause side effects. Common side effects can include fatigue, musculoskeletal pain, decreased appetite, hypertension, and diarrhea. It is important to report any unusual or severe side effects to your healthcare provider.
• Driving and operating machinery: Nubeqa may cause fatigue or dizziness, which can affect your ability to drive or operate machinery. Exercise caution until you understand how the medication affects you.

It is crucial to discuss the potential risks and benefits of Nubeqa with your healthcare provider, as they can provide personalized information and guidance based on your specific situation.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Nubeqa (darolutamide). However, it is always a good idea to follow a healthy, balanced diet as recommended by your healthcare provider. A balanced diet typically includes a variety of fruits, vegetables, whole grains, lean proteins, and healthy fats. If you have any specific dietary concerns or restrictions, it is advisable to consult with a healthcare professional or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Nubeqa, it is generally recommended to take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, it is best to skip the missed dose and continue with your regular dosing schedule. It is important not to take a double dose to make up for a missed one.

What side effects can this medication cause?

Nubeqa (darolutamide) may cause various side effects in some individuals. Common side effects reported with Nubeqa include:

• Fatigue or tiredness
• Musculoskeletal pain, such as back pain, joint pain, or bone pain
• Decreased appetite
• Hypertension (high blood pressure)
• Diarrhea
• Hot flashes
• Falls (especially in elderly patients)
• Fractures (especially in elderly patients)

It’s important to note that not all individuals will experience these side effects, and some may experience different or no side effects at all. Additionally, some side effects may be mild and resolve on their own, while others may require medical attention. If you are concerned about any side effects you are experiencing while taking Nubeqa, it is recommended to consult with your healthcare provider. They can provide guidance, evaluate your specific situation, and determine the best course of action.

It’s also important to report any other unusual or severe side effects to your healthcare provider promptly. They can provide further information and assistance in managing any side effects you may be experiencing.

What should I know about storage and disposal of this medication?

• Storage: Store Nubeqa at room temperature, typically between 68°F and 77°F (20°C and 25°C). Keep the medication in its original container, tightly closed, and protect it from moisture and light. Avoid storing it in the bathroom or any area with high humidity or temperature fluctuations.
• Disposal: Properly dispose of any unused or expired Nubeqa. Follow the disposal instructions provided by your healthcare provider or local guidelines. Do not dispose of medications in household trash or flush them down the toilet unless instructed to do so.

In case of emergency/overdose

In case of an emergency or overdose, contact your local emergency services (such as calling emergency services in your country) or seek immediate medical attention. It’s important to provide healthcare professionals with all the relevant information, including the name of the medication (Nubeqa), the dosage, and the time of the overdose, if known.

What other information should I know?

• Keep all medications, including Nubeqa, out of the reach of children and pets.
• Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking, as there may be potential drug interactions.
• Attend regular follow-up appointments with your healthcare provider to monitor your progress and discuss any concerns or side effects you may be experiencing.
• It’s advisable to carry a medical alert card or wear a medical ID bracelet indicating that you are taking Nubeqa in case of any medical emergencies.
• Inform your healthcare provider about any pre-existing medical conditions you have, especially liver problems or any other significant medical history.

Always follow the instructions provided by your healthcare provider and read the medication guide or patient information leaflet that comes with Nubeqa for detailed and specific information about the medication.